Biomedical subjects

W Norris

Publications and source records attributed to W Norris.

18 recordsLinked to original sources

PubMed1993

What is a HISS? Hospital Information Support System.

A HISS is a Hospital Information Support System and the idea is that it is primarily there to support clinical activity not to provide management information. When the concept of a HISS first emerged it was seen as a very large system where all hospital departments shared one computer system and that is the model used by the first few HISS sites. As the Health Service has changed and the difficulties of replacing all the computer systems in a hospital with one large system have been appreciated, so the concept of HISS has developed. We now talk about an incremental approach to HISS. This means looking at the present systems and deciding which ones should be retained and 'interfaced' with the new system. No system is the best for every department and this approach allowing 'foreign' systems to be attached to the main system (usually centred on the Patient Administrative System) does provide a good fit with the needs of the department. This does not need to be implemented immediately but can be introduced at the end of the life of an existing system, thus protecting the past investment in systems.

Hospital Information Systems↗

PubMed1990

Segmentation and the development of the vertebrate nervous system.

1. Recent experiments on the development of neural segmentation in chick embryos are reviewed. 2. Segmentation of the spinal peripheral nerves is governed by a subdivision of the somite-derived sclerotome into anterior and posterior halves. Migrating neural crest cells and outgrowing motor axons are confined to the anterior sclerotome as a result, in part, of inhibitory interactions with posterior sclerotome cells. 3. The sclerotomal distribution of certain molecules known to influence growing nerve cells in vitro, namely laminin, fibronectin, N-CAM, N-Cadherin and J1/tenascin/cytotactin, suggest that these molecules play no critical role in determining the preference of nerve cells for anterior sclerotome. 4. Peanut agglutinin (PNA) recognises cell surface-associated components on posterior cells which, when incorporated into liposomes, cause the abrupt collapse of sensory growth cones in vitro. The PNA receptor(s) may be inhibitory for nerve cells in vivo. 5. The chick hindbrain epithelium is segmented early in its development. Each branchiomotor nucleus in the series of cranial nerves V, VII and IX derives from a pair of segments lying in register with an adjacent branchial arch. Neurogenesis of motor and reticular axons begins in alternate segments, suggesting parallels with insect pattern formation.

Animals↗

PubMed1975