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Biomedical subjects

W O WEIGLE

Publications and source records attributed to W O WEIGLE.

At least 55 records · Page 3Linked to original sources
PubMed1957

Direct and indirect effects of x-radiation on antibody-producing cells.

X-radiation appears to exert its inhibitory effect on the antibody response by two mutually dependent routes: (a) direct radiation injury to the antibody-producing lymphoid tissue, and (b) indirect effects of altered homeostasis in the radiated host on antibody-producing tissues. Neither of these two effects alone produces significant inhibition of the secondary antibody response made by transferred lymphoid cells. However, 400 to 500 r administered in vitro to the transferred cells, plus 400 r whole body x-radiation of the recipient prior to transfer, completely inhibited the antibody response.

Antibodies↗
PubMed1957

The nature of the immunologic inadequacy of neonatal rabbits as revealed by cell transfer studies.

Lymph node cells capable of either primary or secondary antibody responses following transfer to adult normal or x-radiated homologous recipients make no response following transfer to neonatal homologous recipients. On the basis of the present observations it seems that the environment provided by the neonatal recipient is unsuitable for the immunologic activities of transferred cells in the early phases of the immune response. Neonatal recipients can, however, adequately support cells transferred during the process of active antibody formation. These findings suggest that the immunologic inadequacy of the neonatal animal is related to its internal environment and not necessarily to the lack of cells capable of antibody synthesis.

Animals↗
PubMed1956

Rates of antibody synthesis during first, second, and hyperimmune responses of rabbits to bovine gamma globulin.

Determinations of the rates of antibody synthesis during first, second, and hyperimmune responses to bovine gamma globulin using S(35)-labelle aminod acids indicate the following: 1. In all three responses the rate of antibody synthesis increases while antigen is circulating and then begins to decline rapidly after elimination of detectable circulating antigen. 2. The initial rates of decline of antibody synthesis are approximately the same for all three responses. 3. There is a relatively persistent source of antibody production which appears after repeated stimulation and increases in proportion to the number of repeated stimuli.

Animals↗