Biomedical subjects

W O Young

Publications and source records attributed to W O Young.

At least 19 recordsLinked to original sources

PubMed1993

Pigmented paravenous retinochoroidal atrophy (PPRCA) with optic disc drusen.

Pigmented paravenous retinochoroidal atrophy (PPRCA) is a rare retinal disorder which is diagnosed primarily on its typical funduscopic appearance of retinal pigment epithelial atrophy and clumping in a paravenous distribution. Pigmented paravenous retinochoroidal atrophy is usually asymptomatic and seldom causes marked decrease in visual acuity or significant impairment of electrophysiologic functions. Optic nerve head drusen, which are thought to be inherited as an autosomal dominant trait, rare in blacks, and known to be associated with retinitis pigmentosa, have not been previously reported with PPRCA. The authors present a case of PPRCA which is classic except for an additional finding of optic nerve head drusen. The heritability of PPRCA remains controversial but the authors' reported association of PPRCA and disc drusen seems to suggest some genetic influence.

Atrophy↗

PubMed1990

Static threshold variability in the peripheral visual field in normal subjects.

We assessed the variability of point-wise static threshold values and the components of fluctuation outside the central 30 degrees field in 20 normal individuals tested on the Humphrey field analyzer. We found a mean short-term fluctuation of 2.37 dB, a long-term heterogeneous fluctuation of 5.28 dB, and a long-term homogeneous fluctuation of 1.10 dB. All components of fluctuation were greatest superiorly. Point-wise variation was highest superiorly and nasally and increased with greater eccentricity from fixation in all but the temporal quadrant. Also, point-wise variation was greater between individuals than between tests in a single individual. This study suggests that outside the central 30 degrees field, changes in individual threshold measurements in the superior and nasal quadrants should be greater than those in the temporal or inferior quadrants before they can be distinguished from normal variation.

Adult↗

PubMed1987

Correlation between extent of liver damage in fulminant hepatic necrosis and complexing of circulating group-specific component (vitamin D-binding protein).

Increased complexing of circulating group-specific component (Gc, vitamin D-binding protein) has been found in humans under conditions of presumed increased actin release, and particularly fulminant hepatic necrosis (FHN). We therefore used a hamster model of acetaminophen-induced FHN to further investigate this phenomenon. Liver damage was monitored by aspartate aminotransferase (AST) activity and by histologic examination, and serum Gc was analyzed by polyacrylamide gel electrophoresis (PAGE) and transblotting with anti-Gc. In controls and treated animals displaying slight liver damage, greater than 90% of Gc was of mobility corresponding to native purified hamster Gc, whereas with more severe liver damage up to 100% of Gc was found in one of two cathodal configurations that appear to correspond to complexes with actin. Densitometric quantitation of complexed Gc demonstrated a strong correlation with the severity of liver damage. These results show PAGE to be a useful method of estimating the percentage of Gc complexed in serum, and suggest that cell damage may be followed by the appearance in the circulation of cellular actin that complexes with Gc.

Actins↗

PubMed1978