Biomedical subjects

W Och

Publications and source records attributed to W Och.

5 recordsLinked to original sources

PubMed2001

[Correlation of expression of progesterone receptors with histopathological type and grade of malignancy of cerebral neoplasms].

Steroid receptors play an important role in homeostasis and in proliferation of neoplastic cells as well. Biological effect of steroid hormone on tissues depends on intracellular concentration of its receptor. The binding hormone with its receptor activates adequate genes in cellular nuclei and cell proliferation. The mutation of genes codifying of receptor protein may cause its structural modification or changes in its activity and lead to neoplastic transformation. The aim of our work was the estimation of progesterone receptors (PR) concentration in cerebral neoplasma and correlation with histopathological type and grade of malignancy of cerebral tumours. We examined 89 patients, among them 28 with meningioma, 43 with glioma and 18 with metastatic tumour. The concentration of PR was evaluated using radioreceptor assay. Our results show statistically significant correlation between expression of PR and type and malignancy of neoplastic tumours. It was especially seen in meningioma and the highest concentration of PR were in I grade tumours.

Biomarkers, Tumor↗

PubMed2001

[Syringohydromyelia--coexistence or complication following removal of meningioma of forth ventricle].

Numerous theories have been presented to explain the pathogenesis of syringohydromyelia. Among these is Gardner's hydrodynamic theory with later modifications. Syrinx is usually located in cervical cord and is often associated with Arnold-Chiari, Dandy-Walker malformation or other anomalies of cranio-cervical region. Other theories suggest that syringohydromyelia may be secondary to arachnoiditis, neoplasms or spinal cord trauma. The distal location of the syrinx is very often associated with occult spinal dysraphic lesion. The authors present the case of 28 years old woman operated on meningioma of fourth ventricle. One and a half year later syrinx on Th11-Th12 and coexistent arachnoiditis were recognized. They stress diagnostic and therapeutic difficulties in this case and try to explain of etiology of syringohydromyelia.

Adult↗

PubMedDate not supplied

[Correlation of steroid receptors and growth factors expression with peritumoral edema accompanying cerebral neoplasms].

The aetiology of peritumoral brain oedema still remains unclear, despite investigations, attempted to study the role of various clinical factors and histological features of the tumour. The aim of this investigation was to the evaluate correlation of peritumoral brain oedema with expression of progesterone (PR) and oestrogen (ER) receptors and vascular--endothelial growth factor (VEGF). Eighty nine samples of brain tumours were examined, among them 28 meningiomas, 43 gliomas and 18 metastatic tumours. Expression of steroid receptors was examined with the radioreceptor assay method and expression of VEGF by radioimmune assay. A statistically highly significant correlation was found of VEGF expression with the incidence of diffuse pattern of brain oedema around gliomas and metastatic tumours (p < 0.01). PR expression was associated significantly with the occurrence of localized type of oedema around meningiomas, but in gliomas the expression of this receptor correlated with a diffuse pattern of oedema. No correlation was found between ER expression and peritumoral brain oedema.

Brain Edema↗

PubMedDate not supplied

[Epidermal growth factor expression in brain neoplasms].

Epidermal growth factor (EGF) influences the cell by activation of its specific cell receptor (EGFR). It is regarded as one of the most effective mitogenic factors and plays a role in carcinogenesis. The aim of this study was the assessment of EGF expression in different types of cerebral neoplasms and searching for its correlation with histopathologic features of malignancy and presence of peritumoral oedema. Sixty seven samples of brain tumours were examined. Among them were 17 meningiomas, 34 gliomas and 16 metastases. Expression of EGF was estimated by a radioimmune assay. The authors found the presence of EGF in all types of tumours. No correlation was found between expression of EGF and histopathological signs of tumour malignancy, although a tendency appeared towards a higher level of that factor in anaplastic tumours. Also, no correlation was found between EGF and peritumoral oedema.

Brain Neoplasms↗

PubMedDate not supplied

[Vascular endothelial growth factor expression in cerebral neoplasms].

Angiogenesis plays an important role in growth of neoplasm. Among a variety of proangiogenic agents, vascular endothelial growth factor (VEGF) is regarded as a crucial mediator of tumour angiogenesis. It acts in a paracrine way through the receptors localised in endothelial cells. Many authors maintain that rich vasculature of the neoplasm is associated with its malignant nature. The aim of this study was to examine the relations between expression of VEGF and features of malignancy of brain tumours. Sixty-seven samples of brain tumours were examined: 17 meningiomas, 34 gliomas and 16 metastases to the central nervous system. Expression of VEGF was estimated by radioimmune assay. The authors confirmed the presence of this factor in all types of tumours but the highest concentration of VEGF was found in high-grade gliomas.

Brain Neoplasms↗