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Biomedical subjects

W Oelssner

Publications and source records attributed to W Oelssner.

At least 37 records · Page 2Linked to original sources
PubMed1981

LSD mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility.

Microinjections of LSD (0.05 microgram), mescaline (0.5 microgram) and serotonin (10 microgram) into the medial raphe nucleus of rats resulted in a strong potentiation of apomorphine (1 mg/kg i.p.)-induced hypermotility. The potentiating effect of LSD or serotonin was suppressed by simultaneous injections of methysergide (0.05 microgram) or cyproheptadine (0.05 microgram) into the medial raphe nucleus. The same doses of LSD injected into the dorsal raphe nucleus and of LSD and mescaline injected into the nucleus accumbens failed to influence locomotor activity, whereas injections of higher doses of LSD and mescaline into the nucleus accumbens inhibited spontaneous and apomorphine-stimulated locomotor activity. It is concluded that the potentiating effect of systemically administered low doses of hallucinogens was triggered by preferential actions on the serotonergic system in the medial raphe nucleus.

Animals↗
PubMed1981

Some rules and examples in the treatment of incurable cancer.

Although there are more incurable than curable neoplastic diseases, less attention is given to the treatment of incurable tumours. Taking into consideration the reasons, three principles of treatment do offer themselves for the therapy of patients with incurable neoplastic disease: firstly, the attempt to extend the limits of curability; secondly, palliative treatment as a temporary relief; thirdly, symptomatic therapy. The most important method for extending curability and for palliative treatment is radiotherapy. Some examples of the efficiency of this method are given, including its use in advanced carcinoma of the larynx, carcinoma of the urinary bladder untreated by radical surgery, Wilm's tumour, and carcinoma of the thyroid.

Aged↗
PubMed1980

[Distant metastasis of intensively treated bladder carcinomas].

The successful cure of the local tumour in the urinary bladder with the combination of surgical treatment and hard-ray-therapy prevents in many patients the development of local complications- uremia and anaemia, which were in former time responsible for dead. The prolongated survival time makes convenient the clinical appearance of the latent metastatic formation of the urinary bladder carcinomas by blood and lymph nodes. Here are shown connections between the local growth of the tumour, histological type, kind and frequency of the metastasis. By means of the diagnosis of such tumour diseases we have the possibility of the opportune use for palliative treatment.

Bone Neoplasms↗
PubMed1979

[Value of total nodal radiotherapy in the treatment of lymphogranulomatosis].

From 1968 to 1976 in the Radiological Clinic of the Karl-Marx-University of Leipzig 199 patients with Hodgkin's disease were irradiated, 24 patients totally nodal. As this form of treatment has been used in our institution only since 1976, on account of the small time interval not the survival rate, but only the quota of recidivation could be used for the judgment of the effectiveness of the total nodal irradiation. Compared with the local irradiation the result was a decrease of the distribution recidivations from 82.3% to 20.8%. Also in comparison to the systemic X-ray treatment above or below the diaphragm (= 34% of recidivations) a clear progress was shown.

Cobalt Radioisotopes↗
PubMed1979

Psychotomimetics potentiate locomotor hyperactivity induced by dopaminergic drugs.

The spontaneous locomotor activity of rats was investigated in an open-field test. Apomorphine and d,1-amphetamine caused a dose dependent increase of locomotor activity. LSD, mescaline, and DMT in low doses were ineffective, when given alone, but caused a strong potentiation of the hypermotility induced by apomorphine and d,1-amphetamine. Cyproheptadine antagonized the potentiating effect of LSD without affecting the hypermotility induced by apomorphine, indicating a causal serotonergic involvement in the potentiation effect.

Amphetamine↗
PubMed1978

[Effect of psychotomimetics and haloperidol on head twitching following alcohol withdrawal in mice].

After ethanol withdrawal dependent mice exhibited head twitching. The frequency of head-twitches was decreased by LSD and mescaline in a dose-dependent manner and increased by small doses of haloperidol and physostigmine. LSD antagonized the potentiating effects of haloperidol and physostigmine. The incidence of head-twitches after intracerebral injections of 5-HT in naive mice was lessened by LSD. The involvement of dopaminergic, serotoninergic, and cholinergic transmission systems in the action of psychotomimetics is discussed.

Animals↗
PubMed1978

[Results of telecobalt therapy in non-radically operated bladder neoplasms].

On the basis of the number of patients of the Radiological Clinic of Leipzig Karl Marx University from the years 1969 to 1971 is reported on the results of the telecobalt therapy of the carcinoma of the urinary bladder. Dependent on the local extension of the tumour and on metastasizing the 5-year-survival rate clearly decreases. The analysis of the death rate according to histological criteria refers to the dangerousness of the "atypical papillomas". The altogether favourable 5-year-survival rate of 43,6% of all 181 treated patients emphasizes the effectiveness of the telecobalt therapy. Radiogenic complications appearing should be kept as low as possible by suitable irradiation regimes.

Carcinoma, Squamous Cell↗
PubMed1977

Mouse brain extract with "fibroblast growth factor"-activity.

Crude tissue extracts prepared by homogenization and ammonium sulfate precipitation of mouse brains as described by Gospodarowicz et al. (1975) for brains and hypophyses of cattle have also been found to contain fibroblast growth factor-activity. In the presence as well as in the absence of calf serum in the medium the survival and proliferation of primary mouse embryo fibroblasts in culture were promoted as documented by dose-dependent increase of cell number and protein content during an incubation period of 48 hours. In the case of serum-free incubation also a significant rise of thymidine incorporation induced within 24 hours by the extract was noted. In contrast, the proliferation of primary chicken embryo fibroblasts or transformed mouse cells of the line "L" was not stimulated. Some possibilities for a practical use of such extracts are discussed.

Animals↗