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Biomedical subjects

W P Coleman

Publications and source records attributed to W P Coleman.

At least 19 recordsLinked to original sources
PubMed1999

A visit to the office of Drs. Margaret and Robert Weiss.

This is one of an occasional series of articles about visitations to the offices of prominent dermatologic surgeons. There are a number of highly skilled and innovative members of our field from whom we can all learn. Unfortunately, it is impossible for everyone to visit their facilities and observe their work first hand. The purpose of this series is to provide a behind-the-scenes look at the day-to-day workings of the offices of prominent dermatologic surgeons.

Ambulatory Surgical Procedures↗
PubMed1998

Ultrastructural circuitry of cardiorespiratory reflexes: there is a monosynaptic path between the nucleus of the solitary tract and vagal preganglionic motoneurons controlling atrioventricular conduction in the cat.

We have tested the hypothesis: (1) that presumptive negative dromotropic vagal preganglionic neurons in the ventrolateral nucleus ambiguus (NA-VL) can be selectively labelled from the heart, by injecting one of two fluorescent tracers into the two intracardiac ganglia which independently control sino-atrial (SA) rate or atrioventricular (AV) conduction; i.e., the SA and AV ganglia, respectively. The NA-VL was examined for the presence of single and/or double labelled cells. Over 91% of vagal preganglionic neurons in the NA-VL projecting to either intracardiac ganglion did not project to the second ganglion. Consequently, we also tested the hypothesis: (2) that there is a monosynaptic connection between neurons of the medial, and/or dorsolateral nucleus of the solitary tract (NTS), rostral to obex, and negative dromotropic neurons in the NA-VL. An anterograde tracer was injected into the NTS, and a retrograde tracer into the AV ganglion. The anterograde marker was found in both myelinated and unmyelinated axons in the NA-VL, as well as in nerve terminals. Axo-somatic and axo-dendritic synapses were detected between terminals labelled from the NTS, and retrogradely labelled negative dromotropic neurons in the NA-VL. This is the first ultrastructural demonstration of a monosynaptic pathway between neurons in the NTS and functionally associated (negative dromotropic) cardioinhibitory neurons. The data are consistent with the hypothesis that the neuroanatomical circuitry mediating the vagal baroreflex control of AV conduction may be composed of as few as four neurons in series, although interneurons may also be interposed within the NTS.

Animals↗
PubMed1998

New directions in surgical therapy.

Surgical dermatology continues to evolve rapidly. The field is blessed with a number of bright and enthusiastic young surgeons who are willing to spend to necessary time investigating new techniques. The horizon has changed dramatically over the last 5 years and promises to change even more in the years to come.

Dermatology↗
PubMed1997

Advances in chemical peeling.

Chemical peeling is traditionally discussed in terms of the depth of injury: superficial, medium, or deep. There have been a number of important advances in both superficial and medium-depth chemical peeling over the last several years. This article reviews the state of the art of these techniques and the increasing understanding of their effects on skin.

Chemexfoliation↗
PubMed1997

Liposuction.

Explore the source record for details and available documents.

Humans↗
PubMed1997

Infusion rates and levels of premedication in tumescent liposuction.

BACKGROUND: Tumescent liposuction has proven to be an extremely safe and effective method of liposuction. However, the infusion of tumescent anesthesia can take 1 hour or more to complete. OBJECTIVE: To document the types, dosages, and routes of administration of premedication utilized by four experienced tumescent liposuction surgeons. To determine if infusion rates for tumescent anesthesia are affected by types of premedication. METHODS: Four experienced liposuction surgeons were asked to review their most recent 100 tumescent liposuction patients with respect to types and dosages of premedication and routes of administration. Data were also provided on corresponding infusion pump settings and infusion rates. Volumes of tumescent anesthesia and corresponding volumes of fat aspirated were also collected on the same 400 patients. RESULTS: Infusion of tumescent anesthesia could be performed more rapidly in patients who were given greater amounts of premedication. Volumes of tumescent anesthesia infused were generally two or more times the volume of fat aspirated. Patients could be infused with less premedication if slow infiltration was employed. CONCLUSION: Infusion rates for tumescent anesthesia can be increased of greater amounts of premedication are given. However, this must be balanced against the safety of the premedication.

Adult↗
PubMed1997

The biologic basis of ultrasonic liposuction.

The use of ultrasound to facilitate liposuction is a new and potentially exciting area of clinical and research interest. Whether or not this will result in important changes in the practice of liposuction remains to be determined.

Adipose Tissue↗
PubMed1996

Combining surgical methods for skin resurfacing.

Cutaneous resurfacing with lasers is still in its infancy. As with all new techniques, its proper place will be determined in the context of established procedures. Dermabrasion and chemical peeling have been used by dermatologists for cutaneous resurfacing for over a century. In many patients, any one of these three procedures can be used to achieve excellent results. For others, a specific procedure is clearly more beneficial. For many patients, combining the use of these three techniques achieves maximum benefit. This article discusses the use of combined techniques and when they are indicated.

Chemexfoliation↗
PubMed1996

Assessment of a new device for injecting bovine collagen. The ADG needle.

UNLABELLED: BACKGROUND Bovine collagen has been injected into skin through conventional needles since its introduction in 1981. Variations in technique have resulted in a wide range of clinical results. The success of a collagen treatment depends on proper technique and placement, which may take years of experience to develop. Collagen Corporation has developed a new tool, the ADG needle, which allows more exact control over the depth of injection. OBJECTIVE: To study the clinical benefits of this device in a field evaluation. METHODS: Experienced collagen injectors were asked to evaluate the ADG needle and complete a survey on their experience. RESULTS: A review of treatment of 63 patients by 19 physicians indicated enthusiasm for the new device. Respondees felt that the ADG needle enhanced their ability to place collagen in the dermis and increased the speed of collagen injection. CONCLUSION: The ADG needle is a new tool that enhances depth control and speed when injecting bovine collagen.

Collagen↗
PubMed1996

Dermabrasion for prophylaxis and treatment of actinic keratoses.

BACKGROUND: After dermabrasion, patients with actinic keratoses remain free of new lesions for many years. This clinical effect has been alluded to for 40 years in the dermatologic literature. However, there has been no consensus on how long this clinical benefit actually lasts. OBJECTIVE: To ascertain the longevity of the beneficial effect of dermabrasion, clinical records of patients who underwent this procedure for treatment of actinic keratosis were reviewed. METHOD: Retrospective review. RESULTS: A total of 23 such patients with at least 2 years good clinical follow-up were identified. Their ages ranged from 33 to 76 years. One year after dermabrasion, 96% remained free of new actinic keratoses. The benefits of dermabrasion gradually diminished with 83% clear at 2 years, 79% at 3 years, 64% at 4 years, and 54% at 5 years. The average time after dermabrasion before the appearance of one actinic keratoses was 4 years (median, 4.5 years). Dermabrasion, however did not prevent the appearance of basal cell carcinomas in the perinasal area. CONCLUSION: Dermabrasion provides long-term effective prophylaxis against actinic keratoses and presumably squamous cell carcinomas. The benefits last for an average of 4 years before even one new actinic keratosis reappears. Cryosurgery, 5-Fluorouracil, and chemical peels result in much shorter prophylaxis. Dermabrasion is the most effective modality for prevention of new actinic keratoses.

Adult↗
PubMed1996

Liposuction.

Explore the source record for details and available documents.

Humans↗