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Biomedical subjects

W P Davey

Publications and source records attributed to W P Davey.

8 recordsLinked to original sources

Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man.

1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-y-[(E)-alpha-methylstyryl]- naphthalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg/kg/day and 2 g/day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 weeks of therapy. At the dosage levels of 1, 2, 3, and 6 mg/kg/day there was no decrease in sebum secretion. With the dosage of 2 g/day, a significant decrease in sebum secretion was seen after 8 weeks of treatment with Ro 15-0778.

Acne Vulgaris↗

Treatment of Torulopsis glabrata peritonitis with intraperitoneal amphotericin B.

Torulopsis glabrata peritonitis occurred in a patient after surgery for a ruptured abdominal viscus. The infection was successfully treated with intraperitoneal amphotericin B alone. Pharmacokinetic information regarding the distribution and clearance of amphotericin B administered by this route is presented, and the clinical manifestations and treatment modalities for T glabrata and Candida peritonitis are reviewed.

Abdomen↗

Citation analysis in the literature of tropical medicine.

A brief historical account of tropical medicine as a science is given, followed by a short survey of the development of the literature in the field. The citations indexed in Tropical Diseases Bulletin for a forty-eight-month period (1972-1975) were analyzed according to the journal in which they were published and the language in which they appeared. The results of the study conformed to Bradford's law of bibliographic distribution. The reference scattering coefficient was determined to be 0.504, which indicated a high concentration of articles in relatively few journal titles. A rank order list of sixty-one journal titles is given in an appendix. The study showed English to be the most important language in the literature in terms of productivity. The results of the study may be used as an acquisition tool for developing a journal collection in tropical medicine.

Bibliographies as Topic↗