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W P Milberg

Publications and source records attributed to W P Milberg.

10 recordsLinked to original sources
PubMed1995

Concept generation: validation of a test of executive functioning in a normal aging population.

A new test, Concept Generation, was designed to fractionate the processes that underlie sorting performance in an efficient paper-and-pencil format. The test was administered to 60 subjects, aged 18-79. Results indicated age-related deficits for self-initiated concept formation, shifting set, output monitoring, and perseverative tendencies. When cuing was introduced to increase structure, age group differences were attenuated or eliminated. Within the older group, subgroups were identified based upon the nature of their repetitions. The hypothesis that sorting behavior is mediated by executive functions led to correlational analyses between Concept Generation scores and other measures of executive functioning. The pattern of correlations supported the construct validity of the Concept Generation test. In addition to providing preliminary evidence for the usefulness of Concept Generation in executive functioning assessment, the results replicated and extended previous work on executive functioning in older individuals.

Adolescent↗
PubMed1995

Differential effects of human and animal insulin on the responses to hypoglycemia in elderly patients with NIDDM.

Recent studies suggest that insulin-dependent diabetes mellitus patients switched from animal to human insulin may have decreased awareness of hypoglycemic warning symptoms. The risk of severe or fatal hypoglycemia associated with the treatment of diabetes increases with age. We conducted these studies to determine if awareness of hypoglycemic warning symptoms was greater with animal than with human insulin in elderly patients with diabetes. Nonobese elderly patients with non-insulin-dependent diabetes mellitus (NIDDM) (n = 13; age, 74 +/- 1 years; body mass index, 26.6 +/- 0.7 kg/m2) underwent paired hyperinsulinemic glucose clamp studies (insulin infusion rate 60 mU.m-2.min) in random order. In one study, regular human insulin was infused, and in the other study, regular beef/pork insulin was infused. In all studies, plasma glucose was decreased from fasting levels to 5 mmol/l during the first 60 min and was then allowed to fall to 4.4, 3.8, 3.3, and 2.8 mmol/l in each subsequent hour. Subjects were blinded as to which study they were undergoing. In each study, a hypoglycemic symptom checklist was administered, and counterregulatory hormones were measured every 15 min. Neuropsychological tests were performed every hour. Counterregulatory hormone responses to the two insulin preparations were similar. Autonomic (P < 0.05) and neuroglycopenic (P < 0.01) symptom scores were significantly higher during the beef/pork insulin studies. The responses on the neuropsychological tests were not significantly different. We conclude that beef/pork insulin results in greater awareness of hypoglycemic warning symptoms than does human insulin in elderly patients with NIDDM.

Aged↗
PubMed1993

Dissociable cognitive and neural mechanisms of unilateral visual neglect.

We administered two experimental tasks to 16 patients with neglect following unilateral right hemisphere strokes, designed to probe processing of information in the neglected left visual field. A semantic priming/lexical decision task examined implicit processing of stimuli presented to the neglected field, and a discrimination task required explicit recognition of the same stimuli. We grouped patients according to three patterns of performance: (1) poor discrimination in the left visual field but intact priming, (2) normal priming and discrimination in both fields, and (3) normal priming but poor discrimination in both fields. Although patients in group 1 had posterior lesions, patients in groups 2 and 3 had extensive deep anterior lesions. These results suggest that the clinical phenomenon of unilateral visual neglect can be the surface manifestation of deficits in two different and interacting processes--attentional processes (group 1) and intentional processes (group 2)--or it may be a global attentional disturbance superimposed on these deficits (group 3).

Adult↗
PubMed1992

Priming of spatial configurations in alcoholic Korsakoff's amnesia.

To examine priming for novel, nonverbal patterns, a modification of the paradigm used by Gabrieli et al. (1990, Neuropsychologia, 28, 417-427) was administered to a group of Korsakoff patients, a group of alcoholic controls, and a group of normal controls. Subjects were asked to connect five-dot configurations into the first pattern that came to mind. Priming was than assessed by having the subjects copy experimenter-provided interpretations for each configuration and examining the effect of this manipulation on the subjects' subsequent interpretation of the same configurations. For the Korsakoff patients, the copied prime replaced their initial perceptual interpretation less frequently than it did for normal controls. Instead, the prime had its effect by combining with the baseline percept. These findings suggest that priming for novel, nonverbal material is weaker and less direct for Korsakoff patients than it is for controls.

Aged↗
PubMed1991

Syntactic priming effects in aphasia: an investigation of local syntactic dependencies.

This study explored on-line processing of local syntactic dependencies in normal subjects and in Broca's and Wernicke's aphasics using a lexical decision paradigm. In addition, subjects performed a grammatically judgement task on the real word pairs used in the lexical decision tasks. Results of two experiments for normal subjects indicated different syntactic priming effects as a function of the type of local syntactic dependency. Word pairs that formed a single constituent phrase, i.e., a verb phrase, showed both facilitory and inhibitory effects, whereas word pairs that reflected local syntactic dependencies across a phrase boundary, i.e., pronoun verb, showed only inhibitory effects. Broca's aphasics failed to show facilitory effects when presented with word pairs forming a single constituent phrase but, similar to normals, did show inhibition when presented with word pairs that reflected local syntactic dependencies across a phrase boundary. In contrast, Wernicke's aphasics failed to show inhibitory effects in both experiments. The implications of these results for theories of language processing deficits in aphasia are considered.

Adult↗
PubMed1989

Learning of a complex arithmetic skill in dementia: further evidence for a dissociation between compilation and production.

An amnesic Alzheimer's Disease patient was tested on his ability to learn an algorithm to square two-digit numbers. The results indicated a dissociation in the patient's ability to execute the individual steps of the algorithm and his ability to combine the steps of the algorithm, the former accounting for almost all of the improvement in response time. The results are discussed in conjunction with findings from Charness et al. (1988) and Milberg et al. (1988) and suggest that skill learning in Alzheimer's Disease may be compromised due to an inability to combine individual steps of a procedure.

Adult↗
PubMed1986

Age differences in depicting and perceiving tridimensionality in simple line drawings.

Twelve young adults (M = 21 years) and twelve elderly adults (M = 67 years) were asked to draw a solid cube. The depictions produced by elderly adults were rated by judges as less accurate than the depictions produced by young adults. Both age groups were also asked to evaluate cube drawings that were deliberately distorted in ways characteristic of the depictions produced by older adults. Compared to younger participants, the elderly were more likely to accept distorted drawings as accurate. Control tasks demonstrated that older adults were able to draw and evaluate simpler two-dimensional patterns on par with younger adults. Apparently the mental representation of tridimensional information deteriorates with age leading to deficits in both production and recognition.

Adolescent↗
PubMed1981

The relationship among handedness, sighting dominance, and acuity dominance in elementary school children.

The present study was an attempt to clarify the relationship between handedness, sighting dominance, and eye-acuity in children. Ninety-four males and ninety-seven females between the ages of five and eleven were assessed on standardized measures of handedness, sighting dominance, and visual acuity. Right-handers were more likely to show right-sighting dominance, whereas left-handers had an equal chance of being right-sighted or left-sighted. Acuity dominance was not consistently associated with handedness or sighting dominance. No effects for sex or age were found. It is suggested that further clarification of the function of various lateralized sensorimotor measures is needed before an understanding of how these measures may be related to cortical dominance is possible.

Child↗
PubMed1981

Role of subvocal motor activity in dichotic speech perception and selective attention.

Twenty right-handed male and female subjects were asked for ear-by-ear recall of dichotically presented consonant--vowel syllables. Stimuli within each dichotic pair were contrasted on the features on voicing and/or place, or were differentiated by manner of production. While listening to the stimuli, the subjects were required to concurrently reduce the electromyographic subvocal activity recorded from the lips and throat or from a control site, the frontalis muscle. A right-ear advantage was observed during the control condition, the largest advantage occurring when the pairs were contrasted on both voicing and place. In contrast, a left-ear advantage was observed when subvocal articulatory activity was voluntarily reduced. These results suggest that subvocal articulatory activity contributes to the observed right-ear advantage for speech by affecting attentional bias and not phonetic processing. Possible underlying mechanisms for this effect are discussed.

Attention↗