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Biomedical subjects

W P Muñoz

Publications and source records attributed to W P Muñoz.

5 recordsLinked to original sources

Raised maternal serum alpha-fetoprotein levels not associated with fetal malformations. A case report.

A pregnant black woman was found to have extremely high serum alpha-fetoprotein (AFP) concentrations on several occasions between 18 and 28 weeks of gestation; the amniotic fluid total AFP level was borderline at 22 weeks, and the concanavalin-A non-reactive fraction was below normal. At this stage termination of pregnancy was considered, but qualitative acetylcholinesterase electrophoresis was negative and repeated echographic examinations revealed no fetal defect. The pregnancy was allowed to continue, and a normal premature female infant was delivered at 36 weeks. Possible explanations and the potentially serious implications of the results of laboratory tests in a case such as this are discussed.

Adult↗

The role of Brucella abortus in spontaneous abortion among the black population.

A prospective study on brucellosis in 125 black patients presenting with inevitable or incomplete spontaneous abortion not obviously due to another cause is presented. They were all consecutive cases presenting during weekdays to Edendale Hospital, Pietermaritzburg. Brucellosis was investigated by means of the history and serological and culture studies of intra-uterine swabs. No case of acute Brucella infection was demonstrated; however, there were 5 cases in which the serological finding was consistent with chronic brucellosis (4%). In all these cases no positive evidence of close animal contact could be found; furthermore of the 12,1% of women who actually handled domestic animals, only 1 had a history of previous abortion.

Abortion, Incomplete↗

Biparietal diameter and menstrual age in the black population attending Edendale Hospital.

The relationship between fetal biparietal diameter measured by echography and menstrual age for blacks was studied. Predicted values and their confidence limits are presented in tables and graphs. The biparietal diameter was significantly smaller from 28 weeks than American and European studies, demonstrating that a composite graph was not applicable to the Zulus. The echographic results were checked at term by external cephalometry. Occipitofrontal circumference and birth weights for newborns were found similar to other studies. The smaller BPD in late pregnancy could be explained by the head's shape. The new charts are valuable in assessing fetal growth in African blacks.

Birth Weight↗