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Biomedical subjects

W P Rodman

Publications and source records attributed to W P Rodman.

5 recordsLinked to original sources

Postpartum Candida endophthalmitis.

Two patients experienced endogenous Candida endophthalmitis after childbirth. One case was successfully treated with vitrectomy and intravitreal injection of amphotericin B. Although rare, Candida endophthalmitis must be included in the differential diagnosis in the postpartum patient with visual symptoms.

Adult↗

Human corneal endothelial layer repair during organ culture.

Circular freeze-thaw endothelial wounds were created on paired human corneas. Ultrastructural and physiological studies were performed after organ culture (OC) incubation at 37 C from 1 to 21 days as well as on fresh noncultured controls. As early as 24 hours after injury, OC corneas demonstrated ultrastructurally intact endothelial cells at the margin of the wound, elongating and sliding toward its center. All OC corneas were completely covered by ultrastructurally intact and physiologically functioning endothelial cells by seven days of OC. These cells were approximately twice normal size. Enlarged endothelial cells that maintained deturgescence function were seen in the wounded area after 14 and 21 days of OC. None of the fresh controls demonstrated deturgescence function and in none could ultrastructurally intact endothelial cells be found in the area of the wound. This confirms our hypothesis that during 37 C OC incubation, human corneal endothelium repairs defects in its layer by cells that are physiologically and ultrastructurally intact.

Cornea↗

The cortex of Xenopus laevis embryos: regional differences in composition and biological activity.

The cortex of fertilized Xenopus laevis eggs undergoes regional changes in its composition and morphogenetic activity during the first three divisions. Gray crescent and animal pole cortex of stage 1 (1-cell) and stage 4 (8-cell) embryos each contain a characteristic array of proteins. Implantation of pieces of cortex into the blastocoel of midblastula embryos was used to assay their inductive capacity. The gray crescent cortex was shown to be the only region that had significant axis-inducing activity. This activity increased from stage 1 to stage 4.

Aged↗