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Biomedical subjects

W Paaske

Publications and source records attributed to W Paaske.

9 recordsLinked to original sources

Diagnostic importance of magnetic resonance angiography in arterial reconstructive surgery.

Magnetic resonance angiography (MRA) permits the non-invasive visualisation of blood flow in arteries and veins. It has an enormous potential in imaging of various vascular pathologies and it has been establishing itself as a reliable alternative to widespread contrast X-ray methods explaining morphology of vascular system. This advanced and safe diagnostic method is very rarely used in the clinical practice of vascular surgeons in Slovak republic. The aim of this report is to outline a clinical importance of MRA for arterial reconstructive surgery, its advantages, limitation as an imagine technique and its practical application in different anatomical areas of the human body which are related to operative activity of vascular surgeons. It is intended for briefly comparing MRA with other vascular imagine techniques more common used in clinical practice of our surgical and vascular surgery departments and outpatient clinics.

Aortic Diseases↗

[Infrarenal aortic aneurysm. 1. Etiology and biomechanics].

The etiology of infrarenal, "nonspecific" aortic aneurysms was previously believed to be degenerative arteriosclerosis, but recent studies of the components of the aortic wall have shown that complicated disturbances primarily concerning the synthesis and degradation of elastin and collagen are major pathogenetic components. Non-invasive measurements of the biomechanical properties of the aneurysms and determinations of the directions and forces of local flow velocity vectors within the aneurysmatic sac have provided new knowledge of the abnormal physical factors that follow dilatation. Detailed studies on the biochemical and physiological factors will make it possible to identify patients at risk and provide the foundations for interventions that will prevent development of the disease.

Aortic Aneurysm, Abdominal↗

[Infrarenal aortic aneurysms. 2. Occurrence, diagnosis and treatment].

Infrarenal aortic aneurysms exhibit multifactorial inheritance with massive familial occurrence. Several large screening programmes have shown a general prevalence of about 3% in nonselected populations of patients over 60 years. Danish data on this point are not available, but is seems reasonable to suspect that 30,000-40,000 Danes have the disease. Only 450 operations for infrarenal aortic aneurysms are performed each year in Denmark (population 5.1 mill.). The current information with respect to incidence, prevalence, expansion rate, therapeutical strategies and results of vascular surgical reconstruction is reviewed.

Aortic Aneurysm, Abdominal↗

Classification of peripheral occlusive arterial diseases based on symptoms, signs and distal blood pressure measurements.

Systolic blood pressures at toe and ankle were measured in 459 consecutive patients with occlusive arterial disease. Fifty-eight per cent had intermittent claudication with arterial disease of all degrees of severity. Seventeen per cent complained of rest pain having toe systolic pressures below 30 mmHg, half had arterial lesions proximal to the groin. None had diabetes. Fourteen per cent non-diabetic patients had chronic ulcerations on the foot with arterial lesions similar to those in patients with rest pain. Eleven per cent diabetic patients with chronic ulcerations had less pronounced occlusive arterial disease which was located distally on the legs. A classification in three groups is suggested: (1) ischemia only during exercise; (2) ischemia at rest with or without ulcerations: and (3) diabetics with chronic ulcerations.

Adult↗

Intrinsic regulation of blood flow in adipose tissue.

Previous studies on intact human subcutaneous tissue have shown, that blood flow remains constant during minor changes in perfusion pressure. This so-called autoregulatory response has not been demonstrable in isolated preparations of adipose tissue. In the present study on isolated, denervated subcutaneous tissue in female rabbits only 2 of 12 expts. revealed an autoregulatory response during reduction in arterial perfusion pressure. Effluent blood flow from the tissue in the control state was 15.5 ml/100 g-min (S.D. 6.4, n = 12) corresponding to slight vasodilatation of the exposed tissue. Following total ischemia all experiments showed a period with reactive hyperemia, and both duration of hyperemia and excess flow was related to the duration of the ischemia. This response therefore seems more resistant to the experimental procedure, while autoregulation of blood flow to lowered pressure is more susceptible to surgical exposure of the tissue. During elevation of arterial perfusion pressure blood flow in the isolated tissue showed a transient increase and then almost returned to the level during normotension, indicating an elevated vascular resistance. Raising of venous pressure elicited vasoconstriction with pronounced flow reduction. These two reactions may be important for local regulation of blood flow in subcutaneous tissue during orthostatic changes in arterial and venous pressure. It is concluded that the response in adipose tissue to changes in arterial pressure (autoregulation), venous pressure and total ischemia appear to be elicited by different mechanisms.

Adipose Tissue↗