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W Pfleiderer

Publications and source records attributed to W Pfleiderer.

At least 91 records · Page 5Linked to original sources

The 9-fluorenylmethoxycarbonyl (Fmoc) group and its use in oligonucleotide synthesis.

The introduction of the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group into the exocyclic amino function of 2'-deoxynucleosides and their dimethoxytritylation and phosphitylation is described. The resulting key intermediates were investigated in the built-up of different oligodeoxyribonucleoside phosphate and thiophosphate chains which were deprotected under mild basic conditions leading to crude oligomers of high purity.

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