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W Pilecki

Publications and source records attributed to W Pilecki.

9 recordsLinked to original sources
PubMed2003

The influence of locally implanted high doses of gentamicin on hearing and renal function of newborns treated for acute hematogenous osteomyelitis.

BACKGROUND: [corrected] Osteomyelitis and arthritis still present a serious diagnostic and therapeutic problem. Difficulties arise in particular in the treatment of acute hematogenic osteomyelitis (AHO) in newborns where mega-doses of gentamicin are administered locally for about 3 weeks. Gentamicin possesses strong oto- and nephrotoxicity and the occurrence of these adverse effects depends on the duration of treatment and the serum drug concentration. OBJECTIVE: Aim of the study was to evaluate the influence of local gentamicin application on auditory and kidney functions. MATERIAL AND METHODS: Twenty newborns (14 boys and 6 girls) with AHO were treated at the Department of Pediatric Surgery, Marciniak Hospital, Wroclaw, Poland, by local implantation of miniseptopal or gentamicin sponge. Serum urea, creatinine, antibiotic concentrations and NAG activity/g creatinine ratio in urine were estimated before and 1, 4, 8, 16 days after the operation and compared to values in the control group. Brainstem-evoked auditory potentials (BAEP) were examined before, during the first 3 weeks, and 6-11 months after gentamicin implantation. RESULTS: Mean gentamicin serum concentrations were: 0.67 +/- 0.98 mg/l on the 1st day, 0.16 +/- 0.37 mg/l on the 4th day, 0.03 +/- 0.09 mg/l on the 8th day, 0.01 +/- 0.03 mg/l on the 16th day after operation and did not exceed the upper limit of the therapeutic range. N-acetyl-beta-D-glucosaminidase (NAG)/g creatinine in urine ratios were satisfactory: 77.91 +/- 36.22 UI/g before the operation, 146.51 +/- 82.27 UI/g on the 4th, 162 +/- 111 UI/g on the 8th, 168 +/- 59.83 UI/g on the 16th day after operation and were statistically significantly (p < 0.05) higher than values in the control group. Serum urea and creatinine levels were in the normal range in all groups. Initial BAEP were well in the normal range in 15 of 16 children before treatment and in 14 of 16 children after treatment. CONCLUSIONS: Locally applied gentamicin as miniseptopal or sponge in newborns produces gentamicin concentrations close to the minimal therapeutic serum concentration which are present over a prolonged period. The raised NAG values in urine and normal serum urea and creatinine levels during treatment with gentamicin without concomitant clinical symptoms of renal failure suggest subclinical destruction of the renal tubules. Lack of change in BAEPs shows that there is no impairment of auditory function.

Acetylglucosaminidase↗
PubMed1998

[The effect of the gender of the examined subjects on the course of the visual potentials evoked by the checker board pattern stimulation].

A goal of the present work was to analyze the correlation between a course of visual potentials elicited with the pattern stimulation and gender of the examined subjects. VEPs (Visual Evoked Potentials) recordings were performed using STELLA system in a group of 65 healthy adult subjects, with the age ranging from 18 to 70 years, consisting of the age-matched subgroups of 37 females and 28 males, applying a checkerboard as the pattern-reversal stimulation. In result of the analysis of the individual VEPs parameters, no effect of gender on the P100 latency was found. The discrepancies in the course of VEPs concerned P100 amplitudes, likewise a difference of the maximum and minimum amplitude, which proved to be significantly greater in the recordings collected from the left hemisphere in women than in men. Moreover, there was the appreciably greater symmetry between the responses registered over the both cerebral hemispheres, reflected by the higher correlation coefficients, in the male subgroup compared to the female subjects. The herein reported differences in the VEPs characteristics recorded in the male and female subjects can be elucidated on the ground of the documented discrepancies regarding the structural and functional cerebral organisation in women and men with regards to visual perception.

Adult↗
PubMed1996

[Evaluation of hearing in children with Down syndrome in light of brain-stem auditory evoked potentials].

Down's syndrome is the most frequently occurring chromosomal aberration which causes, among others, central nervous system (CNS) impairment leading to mental retardation as well as lesions of the sensory analyzers. Contrary to former reports, lesions concerning the hearing organ are relatively common and appear, according to various authors, in 40-78% of patients manifesting Down's syndrome. Simultaneously, the low intellectual level of these children is why the results of audiometry are not fully reliable. A method of brain-stem auditory evoked potentials that is objective and does not require the subject's cooperation is a valuable tool for checking the hearing level. The use of this method in a group of children with Down's syndrome permitted an increased hearing levels to be demonstrated in 47% of examined subjects.

Child↗
PubMedDate not supplied

[Exercise test in the neurotic patients].

While testing neurotic patients it was noted that almost all of their complaints concerned physical weakness, easy tiredness, chest pain, heart beating and palpitation. In order to evaluate objectively their physical efficiency, the patients were subjected to exercise test on a treadmill, their ECG, HR and blood pressure being monitored. The exercise test was carried out twice, i.e. before and after 3-month psychotherapy. The average physical efficiency coefficient before treatment was significantly lower than after the treatment, but repolarization disorders were significantly higher before the treatment. ECG analysis proved non-specific repolarization changes induced by excitability of sympathetic system. 8 patients showed changes in ST-T before the treatment and 4 persons after it. Another kind of changes (that appeared in 14 cases before the treatment) were extrasystoles mainly supraventricular. After psychotherapy they were noted only in 1 case. The analysis of HR and blood pressure proved a significantly higher HR and lower blood pressure before the treatment. The obtained results may become an argument supporting the functional character of the changes mentioned.

Adult↗
PubMedDate not supplied

[The evaluation of central visual fatigue in computer terminal users by visual evoked potentials].

Visual evoked potentials (VEPs) were recorded in a group of 20 operators aged 25-45 years during two sessions, before and after a 5-hour work at computer terminals, in order to assess visual system fatigue. The outcomes were referred to the norms established for the age-matched population of 30 subjects not exposed to professional contact with computers. Most of the examined operators suffered various complaints concerning not only the organ of vision but the central nervous system as well. VEPs were elicited by means of monocular stimulation using the reversal checkerboard pattern and recorded simultaneously from the scalp electrodes placed over the right and the left cerebral hemisphere. Only recording acquired after finishing of a working day demonstrated significant statistically abnormalities of the VEPs waveforms, which suggests their transient character. The changes mentioned above included prolongation of peaks P100 and N2 latency with concomitant attenuation of their amplitudes and a decrease of the correlation coefficient values for the recordings from the hemispheres. The preliminary findings presented in this paper seem to justify a conclusion that the non-invasive VEPs method can be considered as the objective indicator of the central visual fatigue induced by the workload at computer terminals.

Accommodation, Ocular↗