PubMed Health⌕ Search

Biomedical subjects

W Placek

Publications and source records attributed to W Placek.

At least 19 recordsLinked to original sources
PubMed2006

Immunogold detection of CD3 and CD4 antigens in patients with Mycosis fungoides.

In this study, we analyzed the distribution of CD3 and CD4 antigens at the ultrastructural level in tissue samples from mycosis fungoides patients using double-immunogold labeling. We observed clusters composed of CD3 and CD4 antigens on the plasma membrane and intracellular. There were also clusters only of one type of the antigen and we could observe more often CD4 than CD3. Labeling of CD3 and CD4 was not found in control cells incubated with non-immune serum. In conclusion, our ultrastructural studies not only visualized pattern distribution and relationship between CD3 and CD4 antigens but might also suggest that the type and form of distribution provides new clues to their possible translocation in mycosis fungoides cells.

CD3 Complex↗
PubMed2001

Cutaneous T-cell lymphoma at a young age.

A case of cutaneous T-cell lymphoma (CTCL) in a 22-month-old patient is discussed, emphasizing the importance of screening for CTCL even in very young patients with atypical symptoms of eczema, atopic dermatitis, or parapsoriasis. The clinical, histologic, and immunologic diagnostics can now be supported by molecular methods; therefore, patients at the earlier stages of CTCL can be diagnosed and treated with good results.

Adolescent↗
PubMed1997

Upper lip reconstruction with local island flap after neoplasm excision.

BACKGROUND: The upper lip is an important esthetic unit of the face and its reconstruction is a big challenge to the dermatosurgeon. OBJECTIVE: The aim of the paper is to present results of upper lip reconstruction for moderately sized defects with single island subcutaneously pedicled flaps, or in combination with additional local flaps. METHODS: Thirteen patients were operated upon mostly for malignant skin neoplasms. Defects of skin only were covered with island flaps planned individually to fit esthetic units of the face. Defects in skin and vermillion were covered with island flaps, and additionally and independently with flaps that reconstructed the vermilion. RESULTS: The healing process was in all the cases but one (partial flap necrosis) free of complications. Follow-up results were also very good functionally and esthetically.

Adult↗
PubMed1996

Psoriasis vulgaris with the early and late onset--HLA phenotype correlations.

The purpose of the study was to classify psoriasis vulgaris basing on HLA phenotype and the age of onset of the disease. One hundred fifteen psoriatic patients were included into the study and divided into two groups: group I--with early onset (< 40 years) and group II--with late onset (> or = 40 years). Each group was subclassified according to Cw6 antigen expression: IA-Cw(6+)--early onset, IB-Cw(6-)--early onset, IIA-Cw(6+)--late onset, IIB-Cw(6-)--late onset. HLA class I antigen typing was performed in each of 115 subjects using the microlymphocytotoxicity test. HLA class II antigen typing was also performed in 20 randomly selected patients by means of the two-step microlymphocytotoxicity test. The occurrence Cw6, B13, B17 antigens was significantly increased in psoriatic groups in comparison with a control population. No difference between the groups was found with respect to class II antigen frequency. Cw6, B13 and B17 were the most specific markers for psoriasis with the early onset, whereas B27, Cw2, B44 and Cw5 seemed to be associated with the late type of the disease.

Adolescent↗
PubMed1989

[Labial flaps in reconstruction of lower lip].

The authors present the evolution of the lower lip reconstruction by labial flaps. Some details of the operation technique and the range of indications for this type of plastic operation have been discussed.

Humans↗
PubMed1988

Sequence of changes in psoriatic epidermis. Immunocompetent cell redistribution precedes altered expression of keratinocyte differentiation markers.

Recent studies suggest that the immune system is involved in the pathogenesis of psoriasis. We studied the expression and distribution of immunocompetent cells and of some chosen differentiation antigens of keratinocytes at various stages of lesion development, using indirect and amplified immunofluorescence, and avidin-biotin-peroxidase method. Serial cryostat sections were collected so as to allow comparative studies of adjacent parts of each biopsy sample with various immunocytochemical markers. Our results indicate that focal intra-epidermal infiltration of otherwise unaltered epidermis with lymphocytes, mostly of the T-helper phenotype, was the first perceptible change occurring in patients with eruptive psoriasis. Modification of the Langerhans' cell staining was observed in these initial subclinical lesions. A significant reduction of the cell frequency was noted in psoriatic papules and plaques. Changes in the epidermal antigen expression could be observed in the developed lesions only. The simultaneous appearance of histologic signs of psoriasis and the modification of keratinocyte antigens indicates that both events are related to the epidermis hyperproliferation, possibly induced by focal inflammatory reaction.

Adolescent↗
PubMedDate not supplied

[Incidence of contact allergy in patients with eczema nummulare].

In patients with eczema nummulare patch tests with a panel of 18 allergens were done with positive result in 9 (18%) cases. In 6 cases multivalent allergy was found. Most frequently positive tests were obtained with potassium dichromate. The tests showed participation of contact allergy in the development of changes in a part of patients with eczema nummulare.

Adult↗