[On drug therapy of spondylitis ankylopoetica].
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Humans↗
Biomedical subjects
W Pohl
Publications and source records attributed to W Pohl.
[Subchondral osteonecroses of large joints in rheumatoid arthritis].
The frequency and preferred localisation of overt subchondral osteonecrosis in large joints have been studied in a roentgenological and clinical study. Among 619 patients (454 female, 165 male) a severe subchondral osteonecrosis was found 44 times on one or more (maximum 3) large joints of 30 patients. The hip and shoulder joints were most frequently attacked, while patients with an advanced stage or longer duration of the disease and those in the middle age groups showed this most often. Osteonecrosis did not necessarily correlate with the activity of the disease process and with the presence of a positive rheumatoid factor. Radiologically, osteolytic appearances are seen most often in the elbow and osteochondritis dissecans in the knee joint. In the hip and shoulder joint the appearances are those of reparative states with a distinct demarcation, more rarely a severe osteolysis also involving the adjacent skeletal parts, occasionally a diffuse irregular lytic osteoporosis and necrosis. The pathogenesis is discussed in detail.
Adult↗
[Diagnostic-therapeutic problems on heart involvement in chronic polyarthritis].
200 in-patients with rheumatoid arthritis (RA) were examined with regard to the diagnostic criteria for early recognition of rheumatoid heart involvement. 75 patients showed some evidence (37.5%). The criteria are: subjectively, reduced general state, feeling of oppression, disproportional tachycardia and dyspnea: objectively, changes in the electrocardiogram (tachycardia, T-inversions sometimes resembling to infarct pictures, disturbances of repolarization, extrasystoles and AV blocks). The severity of the change may alter rapidly. Severe myocarditides may manifest as heart failure and dilatation of rapid onset. For prognostic and therapeutic reasons the recognition of a heart involvement, despite these often minimal appearances, is important. It is remarkable that there was no correlation between the activity of rheumatoid process, the titre of rheumatoid factor, and the degree of heart involvement. Age and age of onset, duration of disease and sex also showed no correlation with rheumatoid heart involvement.
Age Factors↗
[Significance of ear lobe biopsy in the diagnosis of angiopathies inflammatory-rheumatic diseases].
Biopsy of the ear lobule in inflammatory rheumatic and collagen diseases is not a suitable method for detecting vascular involvement. A perivascular cell infiltration van often be found but it non-specific. The intensity of cell infiltration did not correlate with duration, severity or activity of the disease process.
Arthritis, Rheumatoid↗
[Significance of various clinical pictures falling under the general term "rheumatism" for social medicine].
Statistical reports of the "Bundesversicherungsanstalt für Angestellte" and from an affiliated rheumatological rehabilitation clinic show that within the general term of "rheumatism" inflammatory rheumatic diseases are only a few per cents. Myalgic syndromes of the vertebral column without obvious changes of the skeleton rank first. They are followed by degenerative diseases of the vertebral column and peripheral joints. While the number of treatment courses of cardiovascular disorders for men and women (male predominance) remained relatively constant from 1968-1974 and in 50% of the cases lead to pensioning-off, treatment courses of bone and joint diseases have clearly increased with a female predominance; pensioning-off is necessary only in a few cases. There is no correlation between morbidity and number of treatment courses; the importance of economical and social factors for the therapeutic regimen is pointed out. Rehabilitation clinics of the pension-paying institutions offer optimal possibilities of a long term treatment of rheumatic diseases, as single or repeat treatment. The activities of a league against rheumatism should concentrate on the clinically and sociomedically most severe joint diseases.
Germany, West↗
[Muscular changes in ankylosing spondylitis].
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Adult↗
[Plasma cortisol levels during balneotherapy and depot corticoid therapy].
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Adrenal Cortex Hormones↗
[Studies on mobility and prognosis in spondylitis ankylosans].
278 patients with ankylosing spondylitis have been studied in order to find a basis for prognosis by setting a mobility function index of the vertebral column. This index does not depend on manifestation age or on the blood sedimentation rate. It increases with progression of x-ray findings. A coincidence of impaired mobility and overweight is relatively frequent and function index and electrophoresis are correlated. In contrary to this study a study of the course gives probably more prognostic indications.
Adult↗
[Ankylosis in the lower limb in ankylosing spondylitis].
Synostosing ankylosis of lower limb joints was investigated radiologically and clinically in approximately 2000 patients with ankylosing spondylitis. Ankylosis was found in 8 hip joints and in 4 of the joints of the foot skeleton. Most commonly the initial picture of these diseases is that of an arthritis (sometimes specifically misinterpreted as such) years and decades before the manifestation of ankylosing spondylitis appears. The ossifying potential of the disease can apparently manifest itself early in limited areas. The radiological morphology with destruction and reconstruction is found mainly as the well known vertebral changes. Immobilization can at the most be regarded as a favourable factor in a predominantly immunological-inflammatory patho-mechanism. Additional local abnormalities of the vascular or enzymatic systems of the joints can be assumed.
Adolescent↗