[Transarterial occlusion of persistent ductus arteriosus].
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Biomedical subjects
Publications and source records attributed to W Porstmann.
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Patent ductus arteriosus was the first inborn cardiac defect ever eliminated by percutaneous transvascular therapy. The method, results, and complications of Ivalon plugging of the ductus in 208 patients between 5 and 62 years old and treated between 1967 and 1985 are described. Permanent closure was accomplished in 197 patients (94.7%). The following particular benefits are obtainable from the method: no need for thoracotomy; local anesthesia applicable to 65% of all cases; 30 mm average time of intervention; only moderate invasiveness to the patients; only 7 days of hospitalization; good cost-benefit ratio.
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In 30 patients with postinfarction condition (11 infarctions of the posterior wall, 11 infarction of the anterior wall, 8 aneurysms of the anterior wall) the regional contraction of the left ventricle was analysed by 3 different metrical methods (semiaxis, surface and angular method) on the basis of the kineventriculogramme in the 1st oblique diameter. With all 3 methods a significant reduction of the mean contraction amplitude could be proved in the affected ventricular region. Using the semiaxis method, in all 30 patients an asynergy could be identified. By the surface method 2 patients with infarction of the posterior wall and 1 patient with infarction of the anterior wall, by the angular method 3 patients with infarction of the posterior wall and 1 patient with infarction of the anterior wall were not established. According to the disturbance of the entire function of the ventricle the number of the segment with disturbed contraction was largest in the group with aneurysm of the anterior wall and smallest in the group with infarction of the posterior wall. Even here the semiaxis method showed the greatest and the angular method the smallest sensitivity.
The delimitation of regional disturbances of contraction of the left ventricle (asynergies) demands knowledge of the behaviour of the contraction of the normal left ventricle. For the exact recognition of asynergies and for scientific inquiries in these cases the use of objective metrical methods is necessary. Therefore, in 14 patients without organic heart disease the behaviour of the regional contraction of the left ventricle was determined on the basis of the cineventriculography according to three different metrical methods (semiaxis, surface and angular method). For all 3 methods in the first oblique projection of 30 degree a larger mean amplitude of the contraction of the anterior wall was the result in contrast to the posterior wall. Consequently, different borderline regions for the anterior wall and the posterior wall must be established for the delimination of asynergies.
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30 patients underwent implantation of the Mobin-Uppin filter for recurrent life threatening pulmonary embolism. 20 patients could be followed by phlebography. In 11 cases obstruction of the inferior vena cava was observed. Due to the collaterals having developed in the intermediate time there were no significant clinical symptoms below the obstruction.
In 53 external patients with extensive malignant renal tumours before nephrectomy the renal artery was closed centrally by radioopaque ivalonchips. 46 arteries were completely obturated, in 7 cases the embolization was incomplete. This method of embolization is indicated preoperatively because there are some advantages concerning technique of operation. In or ivalon-material there was only one complication without clinical symptoms. The occurring ischemic pain was controllable by medicaments and eased off within some hours. Directly after transcatheter occlusion the patients can be transported back under first aid conditions in hospital where will be nephrectomy carried out.
In 48 patients with angiographically ascertained coronary arteriosclerosis and 15 patients with unconspicuous cardiac findings a complete pressure-flow-volume-analysis of the left ventricle in rest and under artificial atrial tachycardia (atrial pacing) was carried out. In 26 patients with coronary arteriosclerosis a typical angina pectoris could be induced, however, in this group a specific constellation of the findings of the initial values was not present. Under influence of angina pectoris an increase of the disturbances of the regional contraction, connected with a significant decrease of the ejection fraction and of the isovolumetric contractibility parameter Vpm. Apart from this a significant increase of the enddiastolic ventricular pressure and of the quotient deltaP/deltaV in the diastole as a sequel of a decreased distensibility of the ventricle was found. In one part of the patients as an expression of the efficacy of the Frank-Starling-mechanism also the enddiastolic volume increased. Altogether a broad spectre of the functional changes was the result, the direction and degree of severity of which could not be foreseen according to the adequate findings in rest.
384 patients with ischaemic heart disease were treated surgically. Out of 165 patients operated upon consecutively, in 38 (23%) an intramural course of coronary arteries was found. Peroperative diagnosis of the intramural course of the anterior interventricular branch is feasible with a high probability; diagnostic criteria were also elaborated for the intramural course of the marginal branch. Several aspects of the operation technique and tactics are discussed.
Of the X-ray methods for the demonstration of disturbances of the blood supply only the angiography is of practical importance. The proof of vascular calcium on so-called X-ray pictures of the soft parts informs about wall processes, but says absolutely nothing about a disturbed flow. The diagnosis of an obliterating vascular disease is still successful on the extremities with the help of the simple clinical means of pulse palpation, auscultation, measuring of the blood pressure with comparison of the sides, particularly when load methods are included. But the angiography is the only diagnostic method which makes recognizable localisation, extension and degree of obliterating changes intra vitam. Nevertheless it stands at the end of a diagnostic chain and, as far as the ischaemia of the extremities is concerned, it is absolutely indicated only as preoperative method. The development of newer therapeutic methods by means of the saving catheter technique for the restoration of the vascular system is described in short and outlined in its tendencies.
In 15 patients with extensive malignant renal tumours before operation the artery of the kidney concerned was closed by foam substance particles (ivalon) after percutaneous selective catheterisation. The occurring ischaemic pain was controllable by medicaments and eased off after hours. In most cases the nephrectomy followed on the same day, but it can be performed also on the following day. The operation was principally performed from the transverse flank cut in practically bloodless kidney. Compared with the major interventions (transthoraco-abdominal or transabdominal) of the tumour nephrectomy the procedure described in this paper as a more careful one which at the same time meets the principles of modern surgery of cancer and which can also suggested to patients suffering from a severe disease.
The only effective causal therapy in thromboses of the deep pelvic and femoral veins is fibrinolysis or operative thrombectomy. Concerning the contraindications, fibrinolysis is successful only up to the 5th day. After that time patients with deep vein thrombosis were submitted to thrombectomy and at the same time, to prevent renewed thrombosis secondary to a slowing down of the flow, a peripheral arteriovenous fistula was temporarily positioned. Between 1974 and 1976, 14 patients were treated operatively this way. In 6 cases of pulmonary embolism a vena cava umbrella filter was inserted.
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