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Biomedical subjects

W R Gillett

Publications and source records attributed to W R Gillett.

26 records · Page 2Linked to original sources
PubMed1990

Altered humoral immunoregulation during human pregnancy.

The in vitro production of immunoglobulins in response to stimulation with pokeweed mitogen (PWM) and fixed/killed Staphylococcus aureus Cowan 1 (SAC) was measured in conjunction with in vivo assays of plasma immunoglobulin levels to examine the quality and quantity of humoral immunity during human pregnancy and at parturition. Following stimulation with PWM, there is a significant enhancement of in vitro immunoglobulin-G (IgG) production during pregnancy. Following stimulation with PWM and SAC, there was a significant reduction in in vitro immunoglobulin-M (IgM) production immediately following parturition. There was a significant decrease in the plasma levels of IgG during pregnancy, although no change in the plasma levels of IgM were observed. The decrease in plasma immunoglobulin levels during pregnancy cannot be explained as the result of hemodilution and transplacental transfer. Altered humoral immunoregulation is the most likely means whereby an increase in immunoglobulin production during human pregnancy could occur. The possible effects of this on the outcome of pregnancy are discussed.

Antibody Formation↗
PubMed1989

Should intramuscular vitamin K prophylaxis for haemorrhagic disease of the newborn be continued? A decision analysis.

Haemorrhagic disease of the newborn is now a rare life threatening disease due to the widespread use of effective prophylaxis with vitamin K at birth. In recent years the continued need for routine prophylaxis has been questioned and alternative strategies proposed. We have reviewed the literature and using techniques of decision analysis, we reaffirm the need for continued prophylaxis. The cost for each life saved by an oral programme is $4500 and $11,000 for intramuscular prophylaxis. The cost to the state of no prophylactic programme is $6.40 per child born and $0.81 for an oral prophylactic programme. It is recommended that the oral route of vitamin K prophylaxis be adopted as it is equally efficacious with the intramuscular route, but cheaper, more consumer acceptable, and has a lower risk of iatrogenic disease.

Administration, Oral↗
PubMed1989

Tubocornual anastomosis: surgical considerations and coexistent infertility factors in determining the prognosis.

To assess factors that may alter the pregnancy rate in women undergoing tubocornual anastomosis, the cases of 42 women were studied. Because a combination of surgical procedures was performed, the operative side deemed to be the best side was distinguished from the other side. The overall cumulative normal pregnancy rate was 56.0% after 2 years. Deep resection of the intramural tube and cases with technical difficulty had a reduced pregnancy rate. Neither the cornual pathology nor the presence of adnexal adhesions adversely affected the pregnancy rate. Associated infertility factors reduced the chances of conceiving. These factors should give a reliable prognosis to aid in the direction of postoperative management, particularly with regard to in vitro fertilization.

Adult↗
PubMed1989

The surgical treatment of tubal polyps.

Three of 5 women who had resection of intramural tubal polyps as part of their infertility treatment conceived normal pregnancies within 12 months. Linear salpingotomy for the resection of polyps may have a place in the surgical management of infertility.

Adult↗
PubMed1986

Pregnancy rates with artificial insemination by donor: the influence of the cryopreservation method and coexistent infertility factors.

Women entering the AID programme in Dunedin since 1983 were studied to assess the clinical performance of cryopreservation modifications as well as the early assessment of coexistent infertility factors. The cumulative pregnancy rate for normal pregnancies was 45.5% and 64.7% for three months and six months respectively. The conception rate per cycle was 17.9%. These compare favourably with the use of fresh semen in other reports. Except for endometriosis and possibly tubal polyps, treatment of coexistent infertility factors retained this conception rate. With refinements in techniques it is possible that conception rates with AID could approach those of normal fertility.

Adult↗
PubMed1985

Psychological aspects of female sterilisation--assessment of subsequent regret.

In order to study subsequent regret as a complication of female sterilisation, hospital records of women requesting reversal of their sterilisation were compared with women who had not requested a reversal. Regret was more likely in women sterilised at a younger age, but was not associated with lower parity. Women requesting reversal were interviewed to determine the psychosocial factors likely to produce later regret. The clinical implications are discussed.

Adult↗