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Biomedical subjects

W R Keye

Publications and source records attributed to W R Keye.

At least 37 records · Page 2Linked to original sources
PubMed1986

Medical and psychologic characteristics of women presenting with premenstrual symptoms.

To establish the necessary elements of a program of evaluation and treatment of premenstrual syndrome, the medical and psychologic characteristics of 68 consecutive women presenting because of premenstrual symptoms were determined and compared with those of a similar group of 34 women without premenstrual symptoms (control group). Women with premenstrual symptoms exhibited a significantly greater frequency of previously undetected medical, psychologic, and marital problems than did controls. These findings demonstrate the need for a multidisciplinary comprehensive program of evaluation and treatment of the medical, psychologic, and mental health of women who present because of moderate-to-severe premenstrual symptoms.

Adolescent↗
PubMed1985

Medical treatment of premenstrual syndrome.

Treatment of Premenstrual Syndrome has been hampered by the ongoing confusion concerning the etiology of this disorder. Lack of universally accepted diagnostic criteria has been a major factor in the inconclusive and contradictory results of most studies of treatment. Medical treatments which have been used for Premenstrual Syndrome can be divided into three major groups: those that are designed to relieve specific symptoms without attempting to modify the underlying disease process; those that presumably correct what is hypothesized as being the underlying pathophysiology of the disorder; and those that alter the normal ovulatory menstrual cycle. This paper critically reviews a multitude of proposed treatments including psychoactive drugs, diet, exercise, vitamin supplements, hormones and surgery. There is no clear cut evidence of the effectiveness of any of these medical approaches. The emphasis on medical and drug therapies should not discourage physicians from evaluating the effects of psychotherapy on symptom amelioration.

Belladonna Alkaloids↗
PubMed1984

Psychosexual responses to infertility.

Clearly, infertility is one of several gynecologic conditions that may have a profound effect on the psychological and sexual status of its victim. It is obvious from indepth discussions with many infertile couples that they want their physician to help them recognize and deal with these problems. Unfortunately, we are often ill-prepared to meet such a request. Hopefully, however, the next several years will see an increase in the systematic and scientific study of such problems and their solutions, thus providing us with a rational and proven method of dealing with these problems.

Body Image↗
PubMed1984

Environmental exposure and altered menstrual function.

The impact of environmental agents and occupational factors on hypothalamic and pituitary function and menstruation are poorly understood. To date, most research related to environment, occupation, and reproduction has focused on pregnancy outcome, not menstrual function. It is imperative, however, that menstrual function be considered as an outcome variable in the study of reproduction and occupation.

Adolescent↗
PubMed1983

The use of the argon laser in the treatment of experimental endometriosis.

The argon laser offers several theoretical advantages over excision, electrocautery, or CO2 laser therapy for the treatment of peritoneal implants of endometriosis. Therefore, a study of the feasibility of the argon laser for the treatment of endometriosis was performed using five virgin New Zealand White rabbits. Following 6 days of estrogen administration, each animal underwent laparotomy with excision of the right uterine horn. Sections of endometrium were sutured to several peritoneal surfaces. Approximately 3 weeks later the endometrial implants were photocoagulated with the argon laser (488 nm, 2 W, 2-mm spot size, 3 to 5 seconds). Histologic examination of the sites of laser therapy demonstrated complete ablation of the endometriosis with 0.25-mm damage to the underlying tissue and surrounding tissue.

Animals↗
PubMed1983

Photocoagulation of endometriosis by the argon laser through the laparoscope.

Photocoagulation of peritoneal implants of endometriosis was performed in five women during laparoscopy to evaluate infertility. A 600-microns flexible quartz fiber was passed into the abdomen through a suprapubic incision using an instrument with a steerable operating tip. Thirty-one implants of the uterosacral ligaments, ovaries, fallopian tubes, bladder, and sigmoid were photocoagulated without complication or perforation. Because of the selective absorption of the argon laser by the hemoglobin of the endometriosis implants and the ease of photocoagulating implants at laparoscopy, this technique may eventually be an important therapeutic modality for the treatment of endometriosis.

Adult↗
PubMed1981

Microsurgical ovarian transplantation in the primate.

We have developed a technique for orthotopic transplantation of ovaries by microsurgical reanastomosis of the ovarian blood vessels in rhesus monkeys. Four monkeys receiving autografts resumed cyclic menses and had postoperative circulating luteinizing hormone (LH) and progesterone concentrations consistent with developing follicles and corpus luteum function. Postoperative luteal phase ovarian biopsies were indicative of ovulation in three of the four animals. However, in a fifth recipient an ovarian allograft from an unrelated donor was rejected despite the use of a standard immunosuppressive regimen. This study suggests that ovarian transplantation by direct vascular anastomosis is a technically feasible surgical procedure in the human, where the vascular anatomy is similar and the caliber of the ovarian vessels if greater than in the rhesus monkey.

Animals↗
PubMed1980

Prolactin-secreting pituitary adenomas. III. Frequency and diagnosis in amenorrhea-galactorrhea.

Hypocycloidal tomograms of the sella turcica and serum prolactin concentrations were obtained in 146 women with amenorrhea, galactorrhea, or both to diagnose prolactin-secreting pituitary adenomas. Findings suggesting an adenoma, ie, abnormal tomogram and elevated serum prolactin concentration, were found in 24.6% (16/65) of previously unscreened patients and 59.2% (48/81) of prescreened patients. The combination of an abnormal tomogram and elevated prolactin level was relatively specific for an adenoma, as 91% (42/46) of women with these findings who underwent surgery had histologically confirmed tumors. Tumors occurred in women from 15 to 45 years of age, with amenorrhea or galactorrhea ranging from less than six months to more than 20 years in duration. Some women in this series also had obesity, rapid weight loss, polycystic ovarian syndrome, amenorrhea following discontinuance of oral contraceptive use, or emotional stress.

Adenoma↗
PubMed1979

Prolactin-secreting pituitary adenomas in women. II. Menstrual function, pituitary reserves, and prolactin production following microsurgical removal.

A prospective study of 46 women with prolactin-secreting pituitary adenomas and amenorrhea and/or galactorrhea was performed to determine the influence of the selective transsphenoidal removal of these tumors on pituitary and reproductive function. This procedure was effective in restoring menstrual function in 34 of 41 women and in eliminating lactation in 30 of 40 women. Tumor size and preoperative serum prolactin concentrations were the most important factors in predicting the postoperative disappearance of symptoms. Normal menstrual function returned in 33 of 34 women with tumors less than 2 cm in diameter but in only one of seven women with tumors greater than 2 cm. Similarly, galactorrhea disappeared in 29 of 34 women with tumors less than 2 cm but in only one of six women with larger tumors. Menses returned in 31 of 32 women and galactorrhea disappeared in 25 of 31 women with preoperative serum prolactin levels below 200 ng/ml; conversely, menses returned in only three of nine women and lactation ceased in one of six women with preoperative serum prolactin concentrations above 200 ng/ml. Prolactin concentrations decreased in 42 of 43 patients following the removal of pituitary adenomas and returned to normal in 30. Postoperative pituitary reserves of adrenocorticotropic hormone, growth hormone, luteinizing hormone, and follicle-stimulating hormone were normal in most patients. These data indicate that the removal of prolactin-secreting pituitary adenomas by a neurosurgeon accomplished in this surgical technique is effective in restoring menstrual function and eliminating lactation in most women, especially if the tumor is less than 2 cm in diameter and the preoperative serum prolactin concentration is less than 200 ng/ml.

Adenoma↗