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Biomedical subjects

W R Patterson

Publications and source records attributed to W R Patterson.

30 records · Page 2Linked to original sources
PubMed1985

Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy.

Platelets from dogs affected with Basset Hound Hereditary Thrombopathy (BHT), have a thrombasthenia-like aggregation defect but release storage pool ATP in quantities not significantly different from normal controls or BHT heterozygotes when stimulated with 1 X 10(-5)M ADP and 0.22 U/ml thrombin. However, the release occurs so rapidly in the BHT platelets stimulated with ADP that it is complete in approximately one-sixth of the time required for release from normal control and heterozygote platelets. Sequential electron micrographs reveal early release of BHT dense body constituents 30 seconds after stimulation with 1 X 10(-5)M ADP while resting BHT morphology is indistinguishable from normal control animals.

Adenine Nucleotides↗
PubMed1980

Prolonged bleeding time in Aleutian mink associated with a cyclo-oxygenase-independent aggregation defect and nucleotide deficit in blood platelets.

A prolonged mean template bleeding time of 13 minutes was present in nine Aleutian mink affected with Chediak-Higashi syndrome (CHS) compared with 4 minutes in dark control mink. The concentrations of blood platelets in normal and affected animals did not differ significantly. However, in mink with CHS, a marked disturbance of platelet response to collagen was present. Administration of aspirin and indomethacin completely blocked CH platelet response to collagen. Blood platelet adenosine triphosphate and adenosine diphosphate values from mink with CHS were significantly less than those of normal mink, and the platelet adenosine triphosphate/adenosine diphosphate ratios were 10.31 in affected mink and 2.74 in normal mink. These findings are consistent with our previous investigations in affectd cattle and persons and indicate that a "storage pool disease" of platelets exist in the mink with CHS.

Adenine Nucleotides↗
PubMedDate not supplied

Creatine kinase and creatine kinase isoenzymes as a marker of uterine activity.

Creatine kinase (CK) and CK isoenzymes are known to fluctuate in labor. Reliable information about the longitudinal changes of CK and CK isoenzymes during labor is sparse. Nevertheless, they have been used to direct care in women with cardiopulmonary disease and preterm labor requiring tocolysis. This study evaluated fluctuations of CK and its isoenzymes longitudinally across labor in 49 women. Blood samples were obtained at 33 to 34 weeks' estimated gestational age, on admission in labor at 3 cm or less dilation, 8 cm to complete dilation, and postpartum in the recovery room. Specimens were analyzed for total CK, CK-MM, CK-MB, and CK-BB activity. CK levels increased for all peripartum patients (p < 0.001). CK activity at 3 cm was greater than at 34 weeks (p < 0.01). Furthermore, the early rise in CK activity was greater in those in active labor compared with those who required oxytocin stimulation (p < 0.001). CK values at 8 cm and postdelivery (mean IU/liter) were often above nonpregnant norms. The early rise of CK in spontaneously laboring patients versus those requiring oxytocin augmentation may represent a difference in uterine activity. Nonpregnant normative data for CK is not appropriate when assessing cardiovascular side effects of betamimetic therapy.

Biomarkers↗
PubMedDate not supplied

Levels of leakage radiation from electron collimators of a linear accelerator.

The leakage radiation from electron applicators used with our linear accelerator has been measured. For the applicators 6 X 6 to 25 X 25 cm size, the leakage was measured in the plane of the patient and on the sides of the applicators with the available electron energies of 6, 9, 12, 15 and 18 MeV. The levels were significant. The highest leakage on the side was for the combination of 6 X 6-cm applicator and 9-MeV electrons (32%) and in the plane of the patient for 25 X 25-cm applicator with 18 MeV (10%) relative to the peak dose. Adding lead 1-2 mm, at appropriate locations inside the applicators has reduced the leakages to acceptable levels without affecting the beam parameters.

Biophysical Phenomena↗