Carcinomas of the oral mucosa are colonized by a variety of aerobic and anaerobic bacteria. Apart from the normal flora of the oral cavity also organisms of pathogenic potential are found, which may cause postoperative wound infections. A specific antibiotic prophylaxis regimen in extensive head and neck surgery requires identification of the pathopotent organisms and sensitivity testing followed by perioperative individual antimicrobial chemoprophylaxis management. The results of an additional bacteriological examination of the surrounding pharyngeal flora showed no major difference to the range of organisms found in the carcinoma.

Antibiotics, Antineoplastic↗

PubMedDate not supplied

[Perioperative antimicrobial prophylaxis in Obwegeser-Dal Pont surgery for prognathism].

The value of ultra short antimicrobial prophylaxis using azlocillin in preventing postoperative wound infections was studied in a prospective clinical/bacteriological study in 41 orthognathic operations. Preoperatively the oral mucosa and pharyngeal flora of each patient was subjected to bacteriological identification with particular emphasis on anaerobes and sensitivity tests for organisms with established pathogenic potential. The results of a bacteriological examination of the redon drains on day 1 postoperatively indicated a contamination of the surgical wound. Clinically 31 patients showed moderate postoperative edema of the buccal soft tissues and 10 patients had hematomas or hemorrhages. In all patients the operation was followed by primary intraoral wound healing without any signs of an early infection.

Adult↗