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Biomedical subjects

W Reier

Publications and source records attributed to W Reier.

8 recordsLinked to original sources
PubMed1991

[Nocturnal oxygen saturation in patients with coronary heart disease--dependent on degree of left ventricular functional impairment].

It is assumed, that patients with coronary heart disease (CHD) more often suffer from sleep related disorders of breathing than healthy subjects. A relation to an impaired left ventricular performance is discussed. In 40 CHD-patients and 30 cardio-respiratory healthy controls we therefore measured arterial oxygenation during sleep by means of pulse-oximetry. Our results show a marked increase in the frequency of nocturnal oxygen-desaturations along with the degree of impaired left ventricular function independent of a special sleep apnea risk. In case of cardiac insufficiency at rest cyclical oxygen-desaturations were observed ten times as often as in the healthy controls. A central disturbance of the respiratory control, which leads to periodic breathing (type Cheyne-Stokes) has to be discussed. Because of the general high risk of CHD-patients concerning the development of nocturnal complications of their disease, sleep-related disturbances of ventilation have to be detected early by means of routinely applied screening-methods.

Adult↗
PubMed1991

[The inhalation 1 concentration test for the assessment of bronchial reactivity].

An unspecific bronchial provocation challenge with a 1-concentration test is a reliable method to distinguish between normal and hyperreactive persons. The patient inhales a bronchoconstricting substance such as methacholine. A significant change of lung function, for example an increase of airway resistance, characterizes a hyperreactive bronchial system. The continuous registration of transcutaneous oxygen pressure is helpful concerning a strong reaction or a peripheral airway obstruction. An exaggerated increase of airway resistance after provocation test can be treated rapidly by inhalation of sympathicomimetics. No complications were registered. Comparative studies showed a good reproducibility of this method. Summarizing, the 1-concentration test is simple, easy to perform and suitable especially for investigations in occupational medicine or epidemiology.

Airway Resistance↗
PubMed1990

[Comparison of the course of oxygen saturation and transcutaneous oxygen pressure in nonspecific inhalative provocation].

In the case of the unspecific inhalative provocative test, a drop in arterial oxygen pressure often occurs, and can be recorded continuously, with the aid of transcutaneous measurements. In 39 patients, the course of oxygen pressure measured transcutaneously (tcpO2) was compared with the continuous measurement of oxygen saturation (SaO2) employing pulse oximetry. A close correlation was found to exist between maximum tcpO2 and maximum SaO2 decrease. The continuous measurement of oxygen saturation is thus also suitable for the monitoring of the course and for assessing an unspecific inhalative provocation; owing to the course of the oxygen-binding curve, however, the changes are only slight. A positive reaction may be suspected when the oxygen saturation decreases at least 3 per cent.

Blood Gas Monitoring, Transcutaneous↗
PubMed1990

[Dependence of bronchial hyperreactivity on the initial value of airway resistance].

In 403 patients, the influence of the initial value of the airway resistance on the incidence and extent of a positive reaction after an unspecific inhalative provocation with methacholine was investigated. The higher the original airway resistance was, the greater was the probability of obtaining a positive reaction. At an original resistance of more than 4 cm H2O/l/sec. all patients responded with an increase in airway resistance to more than 6 cm H2O/l/sec. In 91 per cent of these patients, the Rt figure increased more than 100 per cent. The extent of the increase in airway resistance following a positive response was independent of the initial value; the effect of subsequent spasmolysis following a positive test result, showed no dependence on the airway resistance prior to provocation.

Airway Resistance↗
PubMed1989

[Transcranial Doppler sonography and hemodynamics].

13 patients without cerebral or cerebrovascular diseases were investigated by transcranial Doppler sonography during Swan-Ganz catheterisation for cardiologic purposes. Massive increases of mean arterial pressure, heart rate and cardiac index were observed during exercise; flow velocities in the middle cerebral artery increased only to the same extent as the endexpiratory carbon dioxide rose. However, the pulsatility index increased significantly (p less than 0.01) although a decrease should have been expected due to carbon dioxide accumulation. These results are indicative of a functioning autoregulation independent of carbon dioxide; they are relevant for interpretation of TCD results in patients with disturbed autoregulation.

Adult↗