[Kinetics of the process of metabolism, absorption and breakdown of drug in the organism].
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Biomedical subjects
Publications and source records attributed to W Rewerski.
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Albino-Swiss male mice were tested in the hot plate test. Oligomeric procyjanidin (OL-1), rutin, quercetin, hyperoside and vitexin rhamnoside were administered intraperitoneally in doses 3.5 and 10 mg/kg. It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level. The mechanism of the analgesic action of flavonoids remains to be explained.
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Effects of some neuroleptic drugs on aggressive behavior in isolated mice. Acta Physiol. Pol. 1979, 30 (2): 295--298. Albino-Swiss male mice were isolated for 28 days and their isolation-induced aggressive behavior was tested after housing them in groups. The effects of the following neuroleptics were investigated: spiroperidol (0.2 mg/kg i.p.), pimozide (1 and 2 mg/kg i.p.), and clozapine (2 and 5 mg/kg i.p.). Among the drugs examined the strongest inhibitory action on the isolation-induced aggressive behavior was inserted by spiroperidol. Primozide and closapine had weaker, but significant anti-aggressive effect.