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Biomedical subjects

W Ricci

Publications and source records attributed to W Ricci.

3 recordsLinked to original sources

Intraneural sciatic nerve pressures relative to the position of the hip and knee: a human cadaveric study.

OBJECTIVES: To determine the effects of ipsilateral hip and knee position on intraneural sciatic nerve pressures. DESIGN: Intraneural sciatic nerve pressures measured in intact, fresh cadaveric specimens relative to ipsilateral hip and knee positions. LOCATION: Medical school anatomy laboratory. SUBJECTS: Randomly acquired adult cadavers. INTERVENTION: Pressure transducer placed within the sciatic nerve distal to the femoral attachment of the gluteus maximus. Intraneural pressures measured with the hip placed in 0, 45, and 90 degrees of flexion while the knee was positioned in 90, 45, and 0 degrees of flexion. MAIN OUTCOME MEASUREMENTS: Tissue fluid pressures within the sciatic nerve relative to the position of the ipsilateral hip and knee. Tissue fluid pressure within the sciatic nerve exceeded previously defined critical thresholds for alteration of neural microcirculation and function. Although increased intraneural pressures were realized as the hip was positioned in greater flexion and the knee was extended, clinically relevant pressures were realized only when the hip was flexed to 90 degrees and the knee was fully extended. Pressures with the limbs in these positions were fifty-five millimeters of mercury (range 38 to 74 millimeters of mercury). RESULTS: With the hip held flexed to 90 degrees, statistically significantly increased intraneural pressures were measured as the knee was extended from 90 to 45 degrees of flexion (p = 0.048) and again from 45 to 0 degrees of flexion (p < or = 0.01). With the knee positioned in 45 degrees of flexion, statistically significantly increased intraneural pressures were measured as the hip was flexed from 45 to 90 degrees (p < or = 0.0062). When the knee was held fully extended, statistically significantly increased intraneural pressures were measured as the hip was flexed from 0 to 45 degrees of flexion (p = 0.0006) and again when the hip was brought from 45 to 90 degrees of flexion (p < or = 0.01). CONCLUSIONS: Intraneural sciatic nerve pressures are influenced by the position of the ipsilateral hip and knee. The magnitude of the pressure elevation appears to be related to the excursion of the nerve as the linear distance between the greater sciatic notch and the distal aspect of the leg increases. Intraneural tissue fluid pressures measured within a localized section of the sciatic nerve appeared to exceed published critical thresholds for alterations of blood flow and neural function only when the hip was flexed to 90 degrees and the knee was fully extended.

Adult↗

Self-disclosure or self presence?

The issue of self-disclosure reflects an interest in allowing the analyst to be present in the analytic situation in a way previously prohibited, as a fully participating subject. The authors develop the concept of the full-fledged communicational context as a way of allowing for, or even requiring, some form of voluntary self-disclosure. Anonymity is examined in the light of its claim to foster patient self-revelation. The authors maintain that such a claim is seriously flawed. Their examination of the concept of analytic objectivity located its foundation in the intersubjective field; therefore, the claim that objectivity is fostered by interpersonal distancing and anonymity is suspect. Further, they assert that asymmetry in the analytic dyad, although unavoidable in many respects, could be significantly reduced, with beneficial effects for both analyst and patient.

Female↗

cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus.

The v-src gene of Schmidt-Ruppin strain A of Rous sarcoma virus is flanked by a 115-nucleotide direct repeat. Mutants that lack either the upstream or downstream copy replicate normally. However, mutants that lack both copies do not replicate. Cloned viral DNA lacking both copies of the 115-nucleotide sequence is capable of directing the transcription of viral RNA posttransfection. This viral RNA is polyadenylated, spliced, exported from the nucleus, and translated into protein normally. However, virions isolated from the culture medium 48 h posttransfection lack viral RNA. When mutant DNA is contransfected with wild-type DNA, the virions produced 48 h later contain wild-type RNA but not mutant RNA, even though both RNAs are present in the cytoplasm. We propose that the 115-nucleotide element of Rous sarcoma-avian leukosis virus encodes a cis-acting sequence that is necessary for the proper incorporation of viral RNA into virions.

Animals↗