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Biomedical subjects

W Riley

Publications and source records attributed to W Riley.

44 records · Page 3Linked to original sources
PubMed1982

Gastric parietal cell and other autoantibodies in the BB rat.

A longitudinal study of circulating autoantibodies in the sera of 48 BB rats was performed by indirect immunofluorescence. No pancreatic islet cell, adrenocortical, or thyroid microsomal autoantibodies were found. However, autoantibodies reactive to gastric parietal cells (PCA), smooth muscle, and thyroid colloidal antigens were identified, PCA were not detected in Wistar-Furth or BB x Wistar-Furth F1 hybrid rats. The range of ages at the time of first appearance of PCA was the same as that of onset of insulin-dependent diabetes (IDD) in the BB rats, suggesting that the processes leading to PCA and IDD were occurring at the same time of life in these animals. The presence of PCA was associated with degrees of lymphocytic gastritis and with squamous metaplasia of the gastric mucosa in the oldest BB rats (9 mo of age). Levels of serum iron and vitamin B12 did not differ between PCA-positive and PCA-negative BB rats, nor was achiorhydria found in any rat studied. The identification of PCA (and chronic gastritis) and other autoantibodies in the BB rat suggests that these animals have an underlying autoimmune diathesis. These findings thus provide indirect support for an autoimmune pathogenesis for IDD in the BB rat.

Achlorhydria↗
PubMed1981

Citizen participation in community mental health center service delivery.

Citizen involvement in CMHC service delivery has two bases: (a) volunteerism and (b) identification with clients and citizens who may need services. This identification is expressed two ways, as cultural similarity to clients or social activism in their behalf. Paraprofessionals have been portrayed as a major mechanism. Current practice shows some discrepancy from the theoretical program goals. While CMHCs include an appreciable number of volunteers and mental health workers with less than a BA degree, the extent to which they augment services with community or social activism values is doubtful.

Community Mental Health Centers↗
PubMed1981

Gonadal autoantibodies in patients with hypogonadism and/or Addison's disease.

The sera from 325 normal individuals, 21 patients with Turner's syndrome, 505 patients with insulin-dependent diabetes mellitus, 15 patients with unexplained ovarian insufficiency, and 37 patients with Addison's disease or serological evidence of adrenal autoimmunity were examined for the presence of gonadal autoantibodies by an indirect immunofluorescent technique using sections of human testis. All 12 patients found to have gonadal autoantibodies also had adrenocortical autoantibodies. These autoantibodies were completely absorbed with powdered adrenal cortex and thus were "steroidal cell" antibodies (SCA), cross-reactive with a cytosolic antigen in the steroid-producing cells of adrenal cortex, placental syncytiotrophoblast, Leydig areas of testis, and theca interna/granulosa layer of ovarian follicles. Sera with SCA had reduced titers of adrenal antibodies after repeated absorptions with gonadal or placental tissues, suggesting that adrenal-specific autoantibodies were also present. Sera from patients with only adrenal antibodies had no significant changes in antibody titers after repeated absorptions with gonadal or placental tissues. In conclusion, all gonadal autoantibodies found were SCA. SCA were only found in patients with adrenal autoimmunity, many of whom had hypogonadism. In other patients or in normal individuals, the existence of SCA or gonadal autoimmunity in the absence of adrenocortical autoantibodies must be rare.

Addison Disease↗
PubMed1979

Comprehensive evaluation model for nursing education.

The proposed model provides structure for determining decisions to be made, questions to be answered, and sources of information about evaluation. A sample of the kinds of decisions that can be made for the various matrix elements of the evaluation model is reflected. Examples of questions that could be asked (why) in order to evaluate various aspects of a program (what) and of whom these questions could be asked (who) are provided. The model as described is useful in comprehensively delineating all aspects of the system. The flexibility of the system allows for the unique needs and aspects of the individual school to emerge. The model also provides a framework for organizing and implementing a plan for total program evaluation.

Data Collection↗