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Biomedical subjects

W Rotzsch

Publications and source records attributed to W Rotzsch.

At least 55 records · Page 3Linked to original sources
PubMed1977

[A model of cooperative analytical diagnosis].

The special branch of clinical chemistry and laboratory diagnostics as an independent speciality has specific comprehensive tasks in research, teaching and education as well as in medical care. Here the organisation of scientific work in the branch of public health concerned is of great importance. For the territory of Leipzig a model a cooperation of medical diagnostics was developed in which a central automation laboratory, a district laboratory and 22 corrdination area laboratories whith all institutions have achieve a high level according to the conditions existing at present.

Clinical Laboratory Techniques↗
PubMed1977

[Central accounting as a model of laboratory diagnosis].

From the experiences in the field of scientific organisation of the last years results a laboratory-diagnostic model with an automatic laboratory, a district laboratory and larger central units, so-called coordination laboratories which work together with about 10 to 20 laboratories and guarantee an up-to-date diagnostic spectre for the whole territory. Apart from the increasing investigation frequency, a constant dilatation of the diagnostic spectre and improved quality control of structural conditions must be taken into consideration. The constructed model which demands the collaboration of all institutions meets these critical problems. A central balancing should also extend to the personal and technical apparative capacity. Apart from this the system is to be extended by further automation in the sense of a machine activity with improvement by control and regulation processes. An electronic data processing improves the functional capacity only when the analytic data processing has achieved a high level. The cooperation in the field of laboratory diagnostics is not only a task in scientific organisation, but in the same way also scientific problems are solved together. The requirements increasing in qualitative and quantitative respect may optimally be fulfilled only by the two partners, clinic and laboratory. With increasing independence the laboratories should in scientific and organizational respect remain a place of meeting for laboratory scientist and physician.

Clinical Laboratory Techniques↗
PubMed1977

[On molecular biology of aging. 11th communication. Enzyme adaptation, age (author's transl)].

Age-dependent modifications of enzyme adaptations in response to a variety of environmental alterations are a biochemical expression of biological ageing. In this paper age-dependent changes of the adaptation of a number of enzymes are described. Experiments from our laboratory indicate that pyruvate kinase is more responsive to starvation and refeeding in young animals. The diminished response of pyruvate kinase in old age is caused by a decreased adaptability of the regulatory isoenzyme PK-L.

Adaptation, Biological↗
PubMed1977

[On moleculare biology of ageing. 10th communication. Enzyme level, age (author's transl)].

The intracellular enzyme level is a function of both the rate of synthesis and the rate of degradation. During aging the levels of a number of enzymes in various animal organs have been found to change; some increase, others decrease. These age dependent changes in enzyme levels may be the result of an alteration in either the rate of enzyme synthesis, or of enzyme degradation or both. The degradation rate constants and the half-life times of citrate cleavage enzyme and glucose-6-phosphate dehydrogenase are uneffected by age, whereas the enzyme levels decrease. Thus the decreased enzyme levels in the liver of old rats can be ascribed to a diminished rate of enzyme synthesis. The half-life time of malic enzyme decreases in dependence of age and the increased enzyme degradation contributes to the diminished enzyme level in the liver old rats.

ATP Citrate (pro-S)-Lyase↗
PubMed1977

[Molecular biology of aging. 8. Aging of intermitotic cells--relationship to protein synthesis in the mucosa of the small intestine].

1. The incorporation of 14C-leucine in a cell free system of intestine mucosa is diminished in aging. 2. The absence of 2-mercaptoethanol in the system of incorporation increases the age differences. 3. By combination of a system from intestine with liver preparation we observed a participation of both the microsomes and the postmicrosomal supernatant. 4. The activity of Ribonuclease is not changes in the aging process. Our results demonstrated the alterations of the intermitotic cells in aging.

Aging↗
PubMed1976

[Biochemical basis of aging].

1. Biological ageing means change of structure and function with the beginning of the autonomy of a human being up to the death of the individual. 2. Already early in the first third of life begin changes caused by ageing, which in concurrence with developmental processes increasingly predominate. 3. Thus the total biological functional capacity of an organism decreases, which we called "vitability". 4. Ageing processes do not only occur on post-mitotic cells, but also on intermitotic cells regular changes caused by ageing are to be established.

Aging↗
PubMed1976

[On the molecular biology of the ageing. VI. Information. Changes of the protein biosynthesis in the age (author's transl)].

1. Most reports in the literature describe a diminished protein synthesis in the old organism. 2. The diminished protein synthesis may be the result of changes of ribosomes, unequal concentration of endogen m-RNA, changes of the activity or concentration of cytosol factors, especially the influence of SH-substances. 3. The age-dependent changes of protein biosynthesis are dependent on the technique of preparation and on the nutrition state of the organism. 4. Addition of 2-mercaptoethanol during preparation or to the incubation medium decreases the age-dependent differences of protein synthesis.

Aging↗