Gastrointestinal endoscopy.
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Costs and Cost Analysis↗
Biomedical subjects
W Ruse
Publications and source records attributed to W Ruse.
Oral iron and the bioavailability of zinc.
The oral bioavailability of zinc was studied in nonpregnant adults before and 24 hours after two weeks of oral supplementation with iron and folic acid. Bioavailability was greatly reduced, and the shape of the plasma curves suggested that this was due to impairment of the intestinal absorption of zinc. The findings suggest that the reduced bioavailability of zinc occurs because of interelement competition in the bowel wall. This might induce zinc depletion.
Biological Availability↗
Peripheral blood leucocyte zinc depletion in babies with intrauterine growth retardation.
The zinc content of peripheral blood leucocytes from the cord blood of 63 normal and 20 preterm babies, and of 27 babies with evidence of idiopathic intrauterine growth retardation (IUGR) was measured. Leucocyte zinc depletion was present in babies with acute IUGR (IUGR babies compared with controls, mean 47.8 v 51.5 ng zinc/mg dry weight), but was especially severe in those with prolonged IUGR (mean 43.2 ng zinc/mg dry weight), while preterm babies were normal (mean 51.9 ng zinc/mg dry weight). We suggest that this fetal tissue zinc depletion is caused by maternal zinc depletion, and may reflect a reduction of whole body zinc status.
Female↗
The hepatointestinal extraction of radiolabelled zinc and altered plasma concentration time curve to oral zinc in chronic liver disease: a mechanism for hyperzincuria in alcoholic cirrhosis.
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Adult↗
Zinc deficiency and photoreceptor dysfunction in chronic liver disease.
1. In nine patients with chronic liver disease photoreceptor function was tested, by measurement of the B-wave amplitude of dark adaptation by electroretinography, and the leucocyte content and plasma concentration of zinc were determined. 2. Four of the patients were leucocyte zinc-depleted and had impaired photoreceptor function, but this was normal in the five with normal leucocyte zinc content.
Adult↗
Direct measurement of the hepatointestinal extraction of zinc in cirrhosis and hepatitis.
1. 65Zn was injected intravenously during transjugular liver biopsy and, from simultaneous hepatic and peripheral venous blood samples, hepatointestinal 65Zn extraction was calculated. Hepatic zinc content was measured in biopsy specimens. 2. On the same occasion samples of liver tissue were taken and their zinc content was measured by atomic absorption spectrophotometry. 3. Seven patients with cirrhosis had significantly lower hepatic zinc content and hepatointestinal zinc extraction than six control patients with mild liver disease. Six patients with chronic hepatitis had a mean hepatointestinal zinc extraction higher than control patients, whereas their mean hepatic zinc content was lower, although the former difference did not achieve statistical significance. 4. These results demonstrate that hepatointestinal extraction of zinc is impaired in cirrhosis, but not in chronic hepatitis.
Blood Pressure↗
Lymphocytic lymphoma presenting with peripheral bony manifestations and with massive renal infiltration responsive to BACOP combination therapy.
A 26-year-old man with diffuse lymphocytic lymphoma presented with painful peripheral bone involvement and with acute renal failure associated with massive lymphomatous renal infiltration. Renal function returned to near normal following combination chemotherapy with bleomycin, adriamycin, cyclophosphamide, vincristine and prednisolone (BACOP).
Adult↗