Torsion of the fallopian tube in a premenarcheal female patient.
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Child↗
Biomedical subjects
W S Barnes
Publications and source records attributed to W S Barnes.
Effects of water immersion on lung volumes: implications for body composition analysis.
Lung volumes of 20 healthy young men were measured before and after water immersion to the neck level. Immersion resulted in significant decreases (P less than 0.01) in forced vital capacity (FVC) (8.9%), expiratory reserve volume (ERV) (61%), total lung capacity (TLC) (5.6%), and functional residual capacity (FRC) (2.9%). Significant increases were observed in inspiratory capacity (IC) (10%) and residual volume (RV) (6.7%). The increase in RV was attributed to a possible "stiffness" of the lung tissue caused by pulmonary vascular engorgement. Densitometric analysis was made on each subject using hydrostatic weighing techniques. Subsequent calculation of body density and per-cent body fat indicated significant (P less than 0.01) differences when using RV measured on land and in water. Body fat was 14.0% using the land RV in the computation of density and decreased to 13.4% using the RV measured in water. It was concluded that when obtaining body density values. RV should be measured concurrently while the subject is in the water.
Adult↗
Fate of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in Sprague-Dawley rats. I. Mutagens in the urine.
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a potent bacterial mutagen formed during cooking of beef. IQ was administered intravenously to Sprague-Dawley rats at concentrations ranging from 7.5-50 mg/kg body weight. Urine was collected and analyzed for mutagenicity. Urinary mutagens were found which required activation by S9 mix, and reverted Ames test strains TA98 and TA100, but not TA1535 or TA1537. The amount of urinary mutagen(s) were related to IQ dose administered and were excreted within 48 h. Additional mutagenic activity was not released after incubation with beta-glucuronidase or aryl sulfatase. Analysis of urinary mutagens by HPLC indicates that the majority of mutagenic activity is due to unchanged IQ, but a small peak of mutagenic activity may correspond to N-acetyl or 3-N-demethylated metabolite. Since only 1% of the administered mutagenic activity is recovered in the urine, IQ may be readily detoxified in vivo.
Animals↗
Clastogenic activity of bile acids and organic acid fractions of human feces.
Chloroform extracts of fecal material from 4 subjects on normal mixed western diets were fractionated to obtain an acid fraction and a hexane extract containing neutrals and bases. The acid fraction from at least 2 of the donors induced an elevated frequency of chromosomal aberrations and exchanges in Chinese hamster ovary (CHO) cells. Since acid steroids are expected to be present in the acid fraction, 5 bile acids were assayed for clastogenic activity in CHO cells. Ursodeoxycholic acid induced chromosomal aberrations and exchanges, and this effect was enhanced by the addition of a microsomal S9 mix. However, the enhancement is probably due to physical factors rather than to enzymatic activity.
Acids↗