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Biomedical subjects

W Sasse

Publications and source records attributed to W Sasse.

16 recordsLinked to original sources
PubMed1994

[DNA ploidy and prognosis of cardia and stomach carcinomas. A comparative flow and image cytometric analysis pf paraffin-embedded tumor sections].

The prognostic relevance of DNA stem line ploidy was ascertained by comparative DNA analysis performed by flow cytometry (FCM) and by Feulgen image cytometry (ICM) of histologic slides on paraffin-embedded resection material from 221 carcinomas of the cardia and stomach. While flow cytometric detection of DNA stem line aneuploidy was rather insecure in smaller or diffuse carcinomas, the methodological restrictions of ICM were seen in a reduced measuring accuracy varying from one case to the other. This resulted in a lower security in distinguishing mere peridiploidy from real hyperdiploid DNA aneuploidy. Despite the difference of methodology, the results were principally concurring. The assessment of DNA stem line ploidy offered no appreciable information about the prognosis of Lauren's diffuse carcinomas. For intestinal carcinomas, however, there was a significant positive correlation between DNA stem line aneuploidy and the evidence of regional nodal metastases, which might explain to a considerable extent the significantly unfavorable clinical course of tumor cases with recorded DNA aneuploidy. The correlation between DNA stem line ploidy, nodal status, and clinical outcome was distinctly less strong in intestinal carcinomas of the cardia than in those of the stomach, because nodal metastatic spread of cardia carcinomas is strongly influenced by local conditions of lymph drainage and the special mechanical strain.

Aneuploidy↗
PubMed1994

[DNA ploidy of stem cells and prognosis of ductal adenocarcinoma of the pancreas].

The findings on DNA stem line ploidy of ductal adenocarcinomas of the pancreas, which have hitherto been published in the literature, are rather contradictory last but not least due to methodological problems. Thus, the DNA stem line ploidy and its prognostic significance were examined by Feulgen image cytometry on 10 microns sections of 100 paraffin-embedded radically resected ductal carcinomas of the pancreas from the records. In that process the parts of the tumour with the highest grade of malignancy were preferentially investigated. The aneuploidy rate (42%) was conspicuously low if compared with other adenocarcinomas. A highly significant positive correlation between DNA ploidy and histological grading according to Klöppel et al. could be observed, while there was only a tendency towards a positive correlation of DNA ploidy and post-surgical tumour stage. Regarding the 1-year survival rate, the DNA aneuploid tumour cases were significantly more unfavourable than the DNA peridiploid ones (p < 0.05). The prognostically decisive parameter, however, was the histological grading (p < 0.00005), which also showed the best stratification of the patient population. However, contrary to expectations the postsurgical stage of the primary tumour and the nodular state were only of low prognostic significance. The reason for that is on the one hand that the distribution over the pT-stages (in 81% pT2 tumours) is unbalanced, and on the other hand that the actual tumour cell dissemination is only insufficiently represented in the post-surgical staging.

Adenocarcinoma↗
PubMed1985

[Perioperative staging and the Münster TNM classification in ampullary and pancreatic cancer].

From 1974 to 1982 607 patients with diseases of the pancreas were treated at the Surgical University Clinic of Münster/West Germany. 256 of those suffered from pancreatic and 42 from ampullary cancer. All patients were grouped according to a TNM-System for pancreatic cancer developed for that particular purpose. Of the curative resections performed (n = 73) with a resection rate of 78.6% for ampullary and 15.6% for pancreatic cancer, a distinct preponderance of early stages (T1N0M0/T2N0M0 greater than 60%) was noticed for the first, of late stages for the latter (T1N0M0/T2N0M0 = 25%). The frequencies of distant metastases for all operations also differed significantly, being 9.5% respectively 43.4% at the time of operation (p less than 0.05). At the low mean survival time for palliative operations an mean survival time of 40.3 months for the Whipple operation was evaluated, of 28.0 months for total pancreatectomy. At the stage T1N0M0/T2N0M0 the mean survival time was greater than 63 months.

Ampulla of Vater↗
PubMed1985

[Prognosis of cardia cancer].

224 of 853 gastric carcinomata in the years 1974-1984 were located in the cardia. Here early stages of carcinoma were less frequent in comparison to the other gastric carcinomas. 46.4% were resectable. Proximal resection was performed in 88 patients, total gastrectomy in 16. Recurrent carcinoma was seen in 27.3%. The 5-year-survival time in all treated patients was 15%, in all resected cases 26%, in all fully resected cases 35%. Stage I showed a five-year-survival time of 42%, stage II of 22%, in stage III and IV no survivors. A generally applicable suggestion as to the radicality of operation can at present not be given. Too many prognostic factors in carcinoma of the cardia cannot be properly assessed.

Adenocarcinoma↗
PubMed1978

[Doppler sonography in venous diseases of the legs].

The Doppler ultrasound is a proper method to diagnose pathologic venous flow in the pelvic and and femoral regions. It is possible to differentiate deep vein thrombosis and chronic venous insufficiency of the typical kind of disturbance. This method permits only functional but not morphological findings; it offers the chance of preselection to other invasive methods.

Doppler Effect↗
PubMed1976

[Computer-supported after-care system for patients with tumors using a cancer-register].

A computerized follow-up system for patients with malignant tumors is described. This system is in use in the "Chirurgische Klinik der Universitat Munster" and in the "Fachklinik Haus Hornheide". As a special service to these clinics a central cancer registry furnishes periodically lists of patients. These lists are used as surveys of treated cancer patients. It is possible to contact those patients by letter, who do not present themselves for clinical examination. Goals of the system are the documentation of the course of disease, the analysis of survival and the follow-up of the patients. Thus, the clinics manage a comprehensive cancer care program with a minimum lost of contact.

Adult↗