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Biomedical subjects

W Sauermann

Publications and source records attributed to W Sauermann.

12 recordsLinked to original sources
PubMed1992

The autoinhibitory feedback control of acetylcholine release in human neocortex tissue.

Slices of human neocortex prelabelled with [3H]choline were superfused and stimulated electrically (3 Hz, 2 ms, 24 mA) in order to investigate the autoreceptor-mediated modulation of acetylcholine (ACh) release. The concentration-response curve of the muscarinic agonist oxotremorine (pKd = 6.76 +/- 0.06), which was equipotent to ACh, was shifted to the right in a parallel manner by atropine (pA2 = 8.56 +/- 0.11), as evaluated by non-linear regression analysis. Calculation of the biophase concentration of ACh showed that no ACh could be assumed to be present under these conditions, whereas following inhibition of the acetylcholinesterase by physostigmine (0.1 microM) a biophase concentration of 10(-6.89 +/- 0.11) M was estimated. The depression of ACh release due to physostigmine and tacrine, another anticholinesterase, was antagonized by atropine. When the autoinhibition was operative atropine and the M2 subtype specific muscarinic antagonists, AF-DX 116 and methoctramine, significantly increased the release of ACh whereas the 'facilitatory' effects of the M1 and M3-specific drugs, pirenzepine and hexahydrosiladifenidol, were not significant. Although different disinhibitory effects of the subtype-specific antagonists were found, they did, however, not show a pattern which would allow a clear characterisation of the subtype of muscarinic receptor associated with the autoreceptor. The release of ACh from neocortex tissue of the (non-demented) neurosurgical patients decreased with their age. This finding is consistent with the hypothesis that the normal aging process resembles a delayed and attenuated disease process of senile dementia of Alzheimer's type.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetylcholine↗
PubMed1991

The conditions of Ca2+ entry via L-type channels for induction of serotonin release from rabbit hippocampus.

The L-type voltage-sensitive calcium channel (VSCC) agonists of the dihydropyridine (DHP) type, Bay K 8644 and (+)-202-791, concentration dependently enhanced the K+ (26.2 mM)-induced 5-HT release from slices of rabbit hippocampus prelabelled with [3H]5-HT when the slices were treated with the monoamine oxidase (MAO) inhibitor, pargyline. The DHP agonists were ineffective on K+ (26.2 mM)-induced release in the absence of pargyline. However, when omega-conotoxin GVIA pretreatment of the slices irreversibly blocked N-type VSCCs, (+)-202-791 markedly enhanced the release of 5-HT evoked by 26.2 mM K+. Thus, at this rather strong stimulus intensity either an increase in the (preferentially cytoplasmic) transmitter pool or blockade of N-type VSCCs was necessary in order to unmask agonist-activated L-type VSCCs. Reduction of the depolarization intensity from 26.2 to 17.2 mM K+, given for 8 min, strongly intensified the stimulatory effects of L-type VSCC agonists irrespective of the use of pargyline under these conditions. The concentration-response curve of (+)-202-791 was 'competitively' shifted to the right by the enantiomer, (-)-202-791, with a pA2 value of 8.6. In conclusion, N- and L-type VSCCs seem to differ in their relation to the cellular machinery for 5-HT release, the latter getting markedly operative when a weak and sustained depolarization is applied or when N-type VSCCs are blocked or when the cytoplasmic transmitter pool is expanded by inhibition of MAO.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethy↗
PubMed1990

[Multiple sclerosis with early manifestation in children].

From the starting point of cases reported in literature, five of the authors' own cases are reported in which multiple sclerosis had its origins not later than in the fourteenth year of the patient's life. There is no basic difference from adult cases in respect of neurological symptoms, course, and cerebrospinal-fluid condition, but unmistakably, well remitting episodic courses were in the foreground, multilocular failures preponderated, and cerebral symptoms predominated over spinal symptoms. As in adult cases, females were more commonly affected. There were inflammatory changes in the cerebrospinal fluid.

Adolescent↗
PubMed1986

[Epileptic seizures in multiple sclerosis].

Starting from informations in the literature, the authors deals with eight own cases, suffering from clinically certain multiple sclerosis and showing, as a further sign, epileptic seizures. Compared to the total of patients, these eight cases represent 1.78 p.c. of all patients treated for multiple sclerosis in this clinic. The features of seizures, frequency and dynamics of occurrence are referred to. The authors point out that it is necessary to differential between epileptic seizures and non-epileptic attacks, and they draw attention to the fact that here are difficulties with regard to differential diagnosis if epileptic seizure appears as a initial symptom of multiple sclerosis.

Adult↗
PubMed1983

[EDP (electronic data processing)-oriented special documentation in neurology--extension to a computer epicrisis].

The contribution describes a final neurological documentation system for in-patients that permits the computerized print-out of an epicrisis. The computer automatically summarizes the elementary findings and presents them as a number of important neurological syndromes. The structure of the documentation and the experience gained in the course of many years of routine application are described. The system has proved to be basically sound under the conditions existing at a university hospital and a specialized hospital for psychiatry and neurology and has proved applicable for a large proportion of the patients without major restrictions.

Aftercare↗
PubMed1983

[Electronic data processing-compatible documentation in neurology--developmental stage of neurologic findings for a specialty-specific scientific evaluation system and print-out of a computer assisted epicrisis].

A computer compatible neurological examination record has been drawn up for a neurological documentation called "ADOK Neurologie" as part of a scheme for the basic registration of patient-related information from all patients receiving ward treatment at the Medical Academy Dresden and the County Neurological and Psychiatric Hospital Arnsdorf. The examination questionnaire consists of dichotomous questions and permits up to 1,525 separate items of neurological information per patient to be stored and processed. The information permits purposeful scientific analysis and computer print-out of the epicrisis. The article reports on the structure of the questionnaire, the prospects and limits of the method and experience gained during many years of practical use.

Computers↗
PubMed1983

[Guillain-Barré polyradiculitis in acute viral hepatitis type B--case report].

A polyneuritis of the Guillain-Barré type developed in a 29 year-old female patient during the icteric stage of viral hepatitis B. The main symptoms were diffuse paresthesias and increasing motor weakness of the limbs, ending up in paralysis of the legs. The analysis of the CSF (albumin raised, cell count normal) and electroneurographic findings were diagnostically reaffirming. The patient was given prednisolone. All symptoms disappeared within two months.

Acute Disease↗
PubMed1979

[Diagnostic problems of chronic misuse of barbiturate-free sedatives].

Atypical neuropsychiatric disease pictures resulting from chronic abuse of barbiturate-free soporifics are often misinterpreted diagnostically. The problems of diagnosis are discussed on the basis of experience gathered by the authors and with due consideration of results reported in the literature.

Diagnosis, Differential↗
PubMed1976

[Preliminary results of imurek treatment of multiple sclerosis].

The authors, after presenting a survey of the literature on the treatment of multiple sclerosis with immunosuppressants, report their experience with Imurek. Of 53 patients with a chronic and progressive course of the disease, objective improvement could be observed in 17. In 20 patients the symptomatology remained unchanged, although 4 of them reported subjective improvement. In 16 patients, progression of the disease could not be stopped. Better results of treatment could be obtained for those forms of the disease where the course was, first, in the form of what may be referred to as outbursts and, later, in a chronic and progressive form. -Possible side effects are pointed out.

Adult↗