[Improvement in the absorption of helveticoside and helveticosol by substitution of the hydroxyl hydrogen on digitoxose].
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Animals↗
Biomedical subjects
W Schaumann
Publications and source records attributed to W Schaumann.
[Metabolism of helveticoside and helveticosol derivatives].
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Acetates↗
[Absorption, distribution and biliary excretion of some 3H-labelled derivatives of helveticosol].
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Animals↗
[Animal experimental comparison of tranquilizing effect of doxepine with known psychopharmaceuticals].
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Aggression↗
[Half-synthetic derivatives of cardiotonic glycosides].
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Acetates↗
[Difficulties in the biological evaluation of digitalis extracts].
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Animals↗
[Differentiation of certain glycosides based on the decrease of their efficacy by potassium and pronethalol].
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Animals↗
[Cardiac effects ofprenylamine and iproveratril in comparison with propanolol, pronethalol an ajmaline].
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Animals↗
[Interference of the central antichloinergic effect in experimental animal tests of potential antidepressives].
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Acetylcholine↗
[Central anticholinergic effectiveness and specifity of some granatan derivatives].
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Aggression↗
[Pharmacologic studies of doxepin, an antidepressive agent with centrally anticholinergic and sedative effects].
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Amitriptyline↗
Pharmacokinetics of metildigoxin and digoxin in geriatric patients with normal and elevated serum creatinine levels.
The pharmacokinetics of digoxin and metildigoxin were investigated in geriatric patients on maintenance treatment. Minimum serum glycoside concentrations were determined on 3 consecutive days, and the elimination rate over a withdrawal period of 4 to 6 days was studied. In patients with serum creatinine levels of less than or equal to 1.3 mg/dl, the oral standard dose D1) of digoxin necessary for a minimum serum concentration of 1.0ng/ml was 1.4 times higher than that of metildigoxin. There was no significant difference in the elimination rate of both glycosides. The pharmacokinetics of metildigoxin were further investigated in patients with elevated serum creatinine levels. The standard dose was best correlated with the creatinine clearance, calculated from the serum creatinine, age, weight and sex of the patients. The apparent volume of distribution of metildigoxin decreased with the drug's total body clearance.
Aged↗