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Biomedical subjects

W Schimmelpfennig

Publications and source records attributed to W Schimmelpfennig.

15 recordsLinked to original sources
PubMed1992

[Leopard spot chorioretinopathy. Initial manifestation of recurrent acute lymphocytic leukemia].

An 11-year-old girl with a history of acute lymphocytic leukemia of the central nervous system had attained complete remission for almost 3 1/2 years after combination chemotherapy and radiotherapy when she developed iritis and chorioretinopathy of the right eye. Neither an anterior chamber tap nor a diagnostic vitrectomy revealed leukemic cells. Both nonspecific anti-inflammatory therapy and antiviral treatment were unsuccessful. Finally, lymphoblasts were detected in the cerebrospinal fluid and in the bone marrow after repeated lumbar puncture and bone marrow aspiration. Combination chemotherapy alone was resumed, resulting in the resolution of all acute ocular symptoms and bone marrow involvement. Only the leopard-spot-like pigmentary fundus changes persisted. The child has now remained in continuous complete remission for 1 1/2 years.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

Bilateral exudative retinal detachment in pregnancy.

A case of bilateral exudative retinal detachment associated with otherwise normal pregnancy is presented. Similar cases, but associated with toxemia of pregnancy from the literature are discussed. As far as we know, this is first reported case where bilateral exudative retinal detachment presented in a normal pregnancy and the re-attachment started promptly after a normal, spontaneous delivery. The re-attachment was complete, and the visual acuity after one year was 20/20 o.u. This case supports earlier theories that hypertension is not the only cause of exudative retinal detachment during pregnancy.

Adolescent↗
PubMed1989

[Studies of biotransformation and liver function from the occupational medicine viewpoint].

General principles of biotransformation are described. Using examples from literature interindividual differences in the biotransformation capacity (induction and disposition) are discussed, especially concerning the combined effect of several xenobiotics (i.e., chemical working materials, ethanol, and drugs). The indocyanine greene excretion rate, the galactose elimination capacity and the 14C-aminopyrine breath test are described in detail as quantitative liver function tests.

Breath Tests↗
PubMed1978

The apoenzyme of aspartate aminotransferase and alanine aminotransferase in the serum of healthy persons and patients suffering from liver diseases.

In activity determination with addition of pyridoxal 5'-phosphate (P-5-P), aspartate aminotransferase (AST) activity increases by 6.5 U/l and that of alanine aminotransferase (ALT) by 2.5 U/l in the serum of healthy persons. This corresponds to a relative stimulation of initial activity by 37% and 15.2%, respectively. ApoAST activity in patients with chronic liver diseases is not changed as compared with that of healthy persons, the relative stimulation rate, however, is significantly smaller. ApoALT activity and corresponding relative stimulation is significantly greater as compared with healthy persons. In the case of acute viral hepatitis, a decrease of AST and ALT activity is followed by a decrease of apoenzyme activity in the course of disease. Diagnostic evidence of determinations of aminotransferase activities could not be improved by addition of P-5-P.

Alanine Transaminase↗
PubMed1978

Lecithin: cholesterol acyltransferase activity in patients with chronic liver diseases and positive LP-X tests.

Lecithin: cholesterol acyltransferase activity has been measured in serum from patients with various liver disorders and positive LP-X tests and from healthy subjects. Statistical analysis indicated that lecithin: cholesterol acyltransferase activity provided no help in the discrimination between the persons of both groups although the mean activities differed significantly.

Chronic Disease↗
PubMed1977

[Expert testimony and rehabilitation in liver cirrhosis].

The principles of rehabilitation of patients with chronic liver disease are expert opinion, therapy and social care. The questions relevant for clinical practice concerning fitness for work, invalidity, disability certificate and nursing money are explained for patients with liver cirrhosis. In such cases a differentiated expert opinion is recommended taking into consideration activity and portal hypertension. The principles of therapy and social care are discussed. Finally with the help of an analysis of the number of patients in the dispensary of the II. medical clinic of the Charité is demonstrated that only about 50% of all cirrhotics are invalidity pensioners. Nearly 1/3 of all cirrhotics with porto-systemic anastomoses has become capable for work.

Adult↗
PubMed1975

[Immunosuppressive long-term treatment of chronic aggressive hepatitis].

47 patients with chronic aggressive hepatitis were immunosuppressively treated on the average 33.8 months (daily dose 100 mg azathioprine and 10 mg prednisolone). The serochemical parameters thymol, ZnSO4, GOT and GPT statistically significantly improved themselves. In 36 patients bioptic controls in 61.1% resulted in an improvement, and in 27.8% of the cases they resulted in a constancy of the histological findings. 10.6% of the patients died of a liver cirrhosis with portal hypertension. Nearly half the patients is capable to work. No severe side-effects appeared. The present results correspond to the results mentioned in literature. The chronic aggressive hepatitis, furthermore, should be added to a prednisone monotherapy or to a combination therapy of azathioprine and prednisone.

Azathioprine↗