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Biomedical subjects

W Schlüter

Publications and source records attributed to W Schlüter.

14 recordsLinked to original sources
PubMed1997

Massive ingestion of the herbicide 2-methyl-4-chlorophenoxyacetic acid (MCPA).

OBJECTIVE: To report the course of a massive ingestion of the herbicide 2-methyl-4-chlorophenoxyacetic acid or MCPA (4-chloro-2-methyl phenoxy acetic acid) and to correlate plasma 2-methyl-4-chlorophenoxyacetic acid levels with symptoms of intoxication and treatment. CASE REPORT: After intentional ingestion of the herbicide, 2-methyl-4-chlorophenoxyacetic acid, a young man suffered burning in his mouth, spasmodic pain in the extremities and a severe hypotensive crisis. Plasma 2-methyl-4-chlorophenoxyacetic acid concentration was 546 mg/L two hours after ingestion. Therapy by forced diuresis was ineffective until the urine was alkalinized (Day 4). This resulted in a rapid decline of the plasma 2-methyl-4-chlorophenoxyacetic acid level to 6 mg/L and recovery of the patient.

2-Methyl-4-chlorophenoxyacetic Acid↗
PubMed1992

Postpartum HELLP syndrome.

Presented is a case of postpartum pre-eclampsia-eclampsia associated with hemolysis, elevated liver enzymes and low platelet count.

Adult↗
PubMed1992

Isolation of an ultrafilterable Ca(2+)-ATPase inhibitor from the plasma of uraemic patients.

1. Calcium concentration and Ca(2+)-ATPase activity under basal conditions and after maximal stimulation with calmodulin were measured in erythrocytes from 32 patients with end-stage renal failure on haemodialysis and from 27 healthy subjects. 2. In patients with renal failure the Ca2+ concentration in erythrocytes was elevated compared with healthy subjects (4.27 +/- 1.02 versus 2.86 +/- 0.57 mumol/l, P less than 0.05). 3. Basal Ca(2+)-ATPase activity was lower in the patients with renal failure than in healthy subjects (4.62 +/- 1.34 versus 5.43 +/- 1.23 pmol of phosphate min-1 10(-6) erythrocytes). After maximal stimulation, Ca(2+)-ATPase activity reached 6.93 +/- 2.81 pmol of phosphate min-1 10(-6) erythrocytes in the patients with renal failure, whereas in healthy subjects stimulation yielded a Ca(2+)-ATPase activity of 32.54 +/- 8.48 pmol of phosphate min-1 10(-6) erythrocytes. 4. Incubation of erythrocytes from healthy subjects with plasma from uraemic patients caused inhibition of Ca(2+)-ATPase. Likewise, the ultrafiltrate from plasma obtained by haemofiltration treatment inhibited Ca(2+)-ATPase. 5. Gel chromatography of the ultrafiltrate and laser desorption/ionization mass spectroscopy revealed that a fraction containing substances with a molecular mass of about 300 Da inhibited Ca(2+)-ATPase. 6. It is concluded that, in uraemia, a Ca(2+)-ATPase inhibitor accumulates in the plasma, and this could contribute to the toxicity of uraemia by inhibiting cellular Ca2+ transport in erythrocytes and possibly other tissues.

Adult↗
PubMed1991

[Manual palpation of the uterine scar following vaginal delivery in previous cesarean section--is it really necessary?].

85 vaginal deliveries following a previous cesarean section were registered during a period of 10 years. After 43 deliveries a palpation of the uterine scar had been carried out. In 42 cases the observation of clinical progress and of the laboratory parameters was preferred. An uterine rupture did not occur. This appears to justify the more expectant attitude in controlling the uterine status after vaginal deliveries following a previous cesarean section.

Adult↗
PubMed1990

[One or two-point devitalization of the fallopian tubes? A study of methods of bipolar high-frequency coagulation].

122 women were sterilized by laparoscopic electrocoagulation of the fallopian tube using bipolar high-frequency current. In 59 cases the coagulation was performed only once in the isthmic part of each fallopian tube, whereas in 63 cases this was done twice at a distance of 2 cm. Only in the first group of women 3 cases of spontaneous recanalization were registered which means a failure rate of 5%. The histologic examination revealed a completely regenerated regular mucous epithelium. The total rate of complications for both groups amounts to 0.8%. Consequently, in its security, the method of burning twice each fallopian tube is definitely superior to the practice of one-point devitalization only.

Adult↗
PubMed1990

[Complete closure or open healing of the skin of the vaginal stump in vaginal hysterectomy].

This retrospective study covers a period of 10 years (1977-1986) during which a vaginal hysterectomy with or without colporrhaphy was carried out in 431 women. In 317 patients the skin at the end of the vaginal stump was closed primarily, whereas it was left open in 114 patients. Comparing both groups less morbidity-, secretion-, infection- and bleeding-rates can be found in the group with primary closure of the vaginal stump. The healing of the operative wound is much better when closed primarily. Fear of entrapped secretions or formation of abscess or hematoma is not justified.

Adult↗
PubMed1989

[Amniotic band syndrome with anencephaly--a case report].

The rare case of a severe amniotic band syndrome associated with anencephaly, hypoplasia of adrenal glands and limb deficiencies is presented and discussed with regard to its probable pathogenesis. Impressive photo- and sonographic material can be shown. Early rupture of amnion seems to be the most probable explanation for this combination of anomalies.

Abnormalities, Multiple↗
PubMed1988

[Congenital hypoplastic left ventricle--a case report].

A case of congenital hypoplasia of left heart ventricle is presented with regard to its clinical and pathophysiological aspects. A detailed prenatal ultrasonic or echocardiographic diagnosis seems to be absolutely necessary. Each sonographer should at least be able to advise of any suspicion of fetal heart abnormalities.

Adult↗
PubMed1988

[Transcervical extra-amniotic induction of abortion in the 1st trimester of pregnancy with 200 micrograms of sulprostone in a hydroxyethylcellulose gel vehicle].

In 104 patients in the first trimenon termination of pregnancy was induced by the extra-amniotic instillation of sulproston prepared in a hydroxyethylcellulose jelly mixture. 89 women got a dose of 100 micrograms Sulproston, 15 a dose of 200 micrograms. In each group of patients the rate of side effects was almost the same. Apart from an average infection rate of 8% there were hardly any peri- or postoperative complications. Also the average abortion score was almost the same in both groups of patients. The average abortion induction interval using the double dose of Sulproston was 8.7 hours, just 1.5 hours shorter in duration as if a dose of only 100 micrograms Sulproston was given. The 100 micrograms dose leads to a 15% failure rate of induced abortion, whereas a 0% failure rate is found when applying a 200 micrograms dose. This advantage together with constant rates of complications and side effects makes the first trimenon termination of pregnancy by extra-amniotic instillation of 200 micrograms Sulproston prepared in a hydroxyethylcellulose jelly mixture appear more favourable than using only a 100 micrograms dose.

Abortifacient Agents↗
PubMedDate not supplied

[Reform of the guardianship and health care right--a contribution of government to the protection of the elderly].

People over the age of majority who are in need of help because of age or sickness must be protected by a modern law of guardianship. Current law with its provisions for declarations of incapacity, guardians for non-minors and tutelage for the frail or infirm rests on outdated concepts of the nineteenth century. Science and practice agree that there is an urgent need for reform. It is not possible to be content with the constitutionally guaranteed principle of proportionality (the requirement that laws bear a reasonable relationship to the ends they are intended to effect); current law permits limitations on legal capacity but does not fully protect either the ward or the involved legal transactions. Current law also does not sufficiently assure that the ward receives personal attention from the guardian or tutor. The German Federal Government has now proposed a draft Guardianship Law. This draft is designed to limit intrusions into the rights of affected persons while also procedurally improving their legal position. The authors approve of this goal; they discuss the essential provisions of the proposed law and come to critical judgments about them.

Aged↗