PubMed Health⌕ Search

Biomedical subjects

W Schlick

Publications and source records attributed to W Schlick.

At least 19 recordsLinked to original sources
PubMed1991

[Uni- and bilateral lung transplantation: functional results. Vienna Lung Transplant Group].

At the end of December 1990 11 patients had survived lung transplantation at the 2nd Department of Surgery, University of Vienna. In these patients 7 single lung (SLTX) and four bilateral lung transplantations (DLTX) were performed. The indication for operation in 6 cases was emphysema, in 2 cases mucoviscidosis, in 2 cases pulmonary fibrosis, and in 1 case secondary pulmonary hypertension, following operation of a ductus Botalli. By means of fitness tests, blood-gas analysis, pulmonary function tests and ventilation respectively perfusion scan a marked improvement of the clinical status of the patients following lung transplantation could be shown.

Adult↗
PubMed1979

[Late results of tracheal resection (author's transl)].

17 cases of tracheal stenosis following prolonged endotracheal intubation are reported. Resection of the stenotic segment and anastomosis were performed in all patients. The clinical result was classified as good in 15 patients and as satisfactory in one patient. One patient died from wound dehiscence and mediastinitis. Results of pre- and postoperative respiratory function tests are presented and the validity of these tests for objective evaluation of operative results is discussed. Diagnostically most informative is the quantitative and qualitative evaluation of airway resistance and MEFV curves.

Adolescent↗
PubMed1979

[Influence of centrophenoxin administered for one year in high dose on maximal oxygen consumption in aged persons (author's transl)].

The influence of centrophenoxin (meclofenoxate) administration in a high daily dosage of 3 grams has been investigated in 10 persons with a mean age of 64 throughout 12 months. The mean age of the control group was 59. The function of bone marrow and a number of indicators of renal and hepatic function has shown no harmful changes after this long term treatment with an extremely high daily dosage. To investigate a possible influence on aging we chose the oral glucose tolerance test, a test battery for pulmonary function and the maximum oxygen consumption capacity. A highly significant (2P smaller than 0,335) influence of the drug for increasing the maximum oxygen input has been found. The hypothesis is presented, that this effect is due to an increase in cardiac functional capacity. Furthermore a significant decrease in fasting glucose levels has been found, while the glucose concentration one and two hours after administration of 100 grams of oral glucose have shown no significant changes. Body weight revealed a small but significant decrease. Side effects: we found a mild gastric pain in 4 patients that disappeared after 20 minutes. 5 Patients complained of a very small increase in jitteriness.

Aged↗
PubMed1978

Specific weight loss in hyperthyroidism.

To assess metabolic turnover in patients with hyperthyroidism weight loss in mg . kg-1 . min-1 (specific weight loss, SWL) was measured by means of a new type of scale working on the buoyance principle with a minimal susceptibility of 10 mg per 100 kg. Weight loss rate was significantly increased in hyperthyroid patients (n=22;SWL, 22.0 +/-1.4 (SE) mg. kg-1 . min-1) compared to health controls (n=11; SWL, 10.0 +/-0.4 (SE) mg . kg-1 . min-1). The fall in SWL paralleled the decrease in thyroid hormone levels in serum in the beginning of antithyroid treatment and remained unchanged thereafter in spite of a further drop in thyroxine (T4) and triiodothyronine (T3) levels. After six weeks of treatment SWL reached the upper normal range despite hormone levels in the low range of normal. The findings indicate that the normalization of the basal metabolic rate as assessed by the estimation of SWL is slower than the decline in serum hormone levels. There was no correlation between thyroid hormone levels and SWL before initiating therapy or during antithyroid treatment (T4 vs. SWL, r = 0.22;n = 56). Thus serum levels of T4 and T3 appear to be rather insufficient indices regarding the respective metabolic state as estimated by SWL.

Adult↗
PubMed1978

[Results of operative treatment of artial septal defect in the adult (author's transl)].

55 of 59 patients with artial septal defect, who had been operated in adult age, were examined postoperatively. The mean time interval from the operation was 43,8 months. Two patients had died immediately after the operation; there were no late deaths. The majority of the reexamined subjects was free of symptoms, in no case was there congestive heart failure. Persistence of postoperative symptoms increased with increasing age at the time of operation, but only up to the fourth decade of life. In 26 cases hemodynamics were examined. Mean pulmonary arterial pressure was normal at rest and during a slight ergometric load. In 5 patients there was moderate pulmonary hypertension. In 8 subjects there was minimal, in one patient moderate increase of pulmonary vascular resistance. Heartsize in chest roentgenogramm was increased in about 25% of cases, in more than 50% the pulmonary vessels were accentuated. Irregularities of cardiac rhythm were not more frequent postoperatively, than they had been prior to surgery. However, surgery was followed by a marked decrease of right axis deviation and of EKG signs of right ventricular hypertrophy. Pulmonary function studies revealed a slight decrease of vital capacity and of maximal breathing capacity. These results are favourable compaired to medically treated groups of patients as described in the literature. It is concluded, that even in later adult age the atrial septal defect as a rule is an indication for surgery.

Adult↗
PubMed1977

[Pulmonary emphysema. Changes in the pulmonary function of experimentally induced emphysema].

By intratracheal injection of the protease papain to experimental animals parenchymal changes in the lung can be induced, that resemble human emphysema. Papain (dosage 26 to 112 mg, 1 to 4 injections) was given intratracheally to 8 bastard dogs (weighing from 12.5 to 20 kg) during light general anesthesia. Pulmonary function was assessed in weekly intervals and related to morphologic changes in the lung. Static compliance of the lung and FRC measured during respiratory arrest were increased after papain, bronchial resistance, measured while artifically ventilated at constant pressure was also increased. Changes of static lung compliance and FRC were seen after the first administration of papain, but further increased with time of observation and after multiple doses of papain. Increase of resistance was not found before 5 weeks. At quiet breathing resistance was not increased at all. No significant changes were found of arterial pO2 and pCO2, pH, standard and actual bicarbonate, diffusion capacity for O2, tidal volume, minute ventilation and ventilatory rate. Morphological findings confirmed the changes described by others. Pulmonary function appears to be pathological at a time when morphology still seems to be normal. The question is discussed to what extent the model of experimental emphysema induced by proteolytic enzymes can contribute to the understanding of human pulmonary emphysema. Lung function in the course of experimental emphysema is compared with function in different clinical types of emphysema.

Acid-Base Equilibrium↗
PubMed1977

[Bronchospirometric results after single lung homotransplantation in dogs with experimentally induced pulmonary emphysema (author's transl)].

Pulmonary emphysema was induced in 8 bastard dogs by intratracheal instillation of Papain. Development of emphysema was documented by pulmonary function tests. The emphysematous animals underwent single lung homotransplantation. Postoperative bronchospirometric measurements revealed that up to the 6th week after transplantation there is no evidence of serious ventilation perfusion inbalance.

Airway Resistance↗
PubMed1976

Measurement of gas free body volume by a diving device.

A device is presented for determination of gas free body volume, by which total body volume as well as lung volume together with intestinal gas can be measured. The measurement is performed under water. The subject to be measured keeps his head in an airfilled cylinder which allows free breathing during the measurement procedure under water. The subject sits on a seat which is connected with a vertical "probe" that is submerged in a water basin. This "body density probe" carries several measuring rods of different diameter on its upper end, which lead to an increase of buoyancy when sinking deeper into the water after additional weights have been put on the device. These rods lead to new equilibrium states which are also dependent on the compressable gas volume attached to the probe. Three equilibrium states with different added weights give a physical definition of gas free body volume, which can be calculated from a number of accurately measurable single items.

Anthropometry↗
PubMed1976

[Body composition in lean and obese persons determined by "lift balance densitometer" (author's transl)].

A new method was used to measure body density in 125 persons (divided into five groups: lean male and female; extremely obese male and female; moderately obese female). There was no correlation between body weight and total body fat in lean males, but a good correlation in lean females. Fat-free body mass correlated well with body weight in both lean groups. There was good correlation between body weight and total body fat in obese males and females. Relative weight (weight related to Broca index) correlated well with fat percentage in obese males, females, and lean women, but not in lean males. The results suggest that the Broca index of over-weight (percentage over-weight = height in cm minus 100) is a good measure of obesity in females and in extremely over-weight males, but no conclusion can be drawn about the amount of fat tissue in males who are only moderately over-weight or under-weight. In these persons fat-free body mass correlates better with body weight than "obesity tissue".

Adult↗
PubMed1976

[A new method for determining the body composition with the aid of a displacement balance and low-pressure volumetric analysis (author's transl)].

A new method for determination of the specific weight of the gas-free human body is presented. Volume measurement is facilitated by extremely precise scales, by means of which a well-defined amount of water which was removed from a "patient container" is weighed. After the test subject has entered the container and is standing up to the neck in water, the container is closed. The combined gas volume consisting of the subject's lung volume, his intestinal gas and the air around his head is measured by lowering the pressure by an exactly-defined amount. This is done by opening a valve at the bottom of the container, which results in the outflow of a certain amount of water, the volume of which corresponds to the volume expansion inside the container. The gas volume prior to expansion can then be calculated by application of the gas laws. The advantages of this measuring device are its relatively small size, the high precision and the fact that the procedure is not unpleasant for the subject, as the head is not submerged under water.

Body Composition↗
PubMed1976

[Roentgenmorphologic findings in single homotransplantation of non immunosuppressive treated canine lungs (author's transl)].

According to plain chest roentgenography correlated to needle biopsies the following grades in the course of rejection after single lungtransplantation could be evaluated. 1) Begin of rejection: perihilar alveolar infiltrate. 2) Increase of the infiltrates (positive Airbronchogram). 3) Almost total consolidation of the graft. 4) Complete consolidation of the graft, mediastinal hernia caused by the own lung.

Animals↗