Biomedical subjects
W Schneller
Publications and source records attributed to W Schneller.
Thermally activated escape over time-modulated fluctuating barriers.
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Simulation of alpha-helix-coil transitions in simplified polyvaline: equilibrium properties and Brownian dynamics.
A quantitative understanding of helix-coil dynamics will help explain their role in protein folding and in folded proteins. As a contribution to the understanding, the equilibrium and dynamical aspects of the helix-coil transition in polyvaline have been studied by computer simulation using a simplified model of the polypeptide chain. Each amino acid residue is treated as a single quasi-particle in an effective potential that approximates the potential of mean force in solution. The equilibrium properties examined include the helix-coil transition and its dependence on chain position and well depth at the coil-helix interface. A stochastic simulation of the Brownian motion of the chain in its solvent surroundings has been used to investigate dynamical properties. Time histories of the dihedral angles have been used to study the behavior of the helical structure. Auto and cross-correlation functions have been calculated from the time histories and from the state (helix or coil) functions of the residues with relaxation times of tens to hundreds of picoseconds. Helix-coil rate constants of tens of ns-1 were found for both directions of the transition.
[A 39-year-old heavy smoker with acute effort dyspnea and fever].
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Disseminated candidosis following tuberculous meningitis.
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Pulmonary histiocytosis X in adult patients.
Clinical findings and course of the disease are described in 6 patients suffering from pulmonary histiocytosis X. Diagnosis was suspected when a reticulo-nodular pattern was detected by conventional X-ray or by computerized tomography of the lungs. Laboratory tests were non-specifically altered, lung function was impaired. Signs of the disease improved spontaneously in one patient and when cytostatics were given in two of five patients. To judge the course of the disease, repeated controls of lung function parameters -- besides roentgenographic methods -- were of particular value.
Therapy in pulmonary histiocytosis X.
Clinical findings and course of the disease are described in six patients suffering from pulmonary histiocytosis X. Diagnosis was suspected when a reticulonodular pattern was detected by conventional X-ray or by computerized tomography of the lungs. Laboratory tests were altered nonspecifically, and lung function was impaired. Signs of the disease improved spontaneously in one patient and when cytostatics were given in two of five patients. To judge the course of the disease, repeated controls of lung function parameters - besides roentgenographic methods - were of particular value.
[An anlysis of the post mortem material of a chest unit (author's transl)].
Tuberculous persons tend to live longer, i.e. death from tuberculosis has shifted to the older age groups. Cavitating processes frequently accompany intestinal tuberculosis, but not tuberculosis of the bones and joints. Fungus infections were found in 36 of 846 post mortem examinations, in 22 cases in association with tuberculosis.
[Proceedings: Tuberculosis as a natural science problem].
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[Problems of the XYY constitution].
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