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Biomedical subjects

W Schroeder

Publications and source records attributed to W Schroeder.

At least 19 recordsLinked to original sources
PubMed1992

[Results of the bimedial muscle belt].

The effectivity of a retroequatorial muscle belt operation, modification of Cüppers' Fadenoperation, is demonstrated by its results in 206 patients with excess esotropia at near and variable angle esotropia. It is shown that this procedure can reduce excess esotropia at near by a significant amount and lessen the extent of variable angle esotropia without causing incomitance in horizontal eye motility. A belt, placed bimedially on both recti muscles, showed to be twice as effective on the deviation at near as on the angle at distance. Proposing a similar mode of action, the atraumatic fixation with the muscle belt can facilitate reoperations in comparison with the Fadenoperation. Damage to the muscle is limited to a minimum.

Child, Preschool↗
PubMed1992

Collagenous colitis: jejunal and colorectal pathology.

AIMS: To determine: (1) whether there is an association between collagenous colitis and coeliac disease or lymphocytic colitis; (2) the distribution of lymphocyte subsets and macrophages in the lamina propria and surface epithelial layer in collagenous colitis; and (3) the colorectal distribution of the disease and whether a mucosal biopsy specimen, using a flexible sigmoidoscope, is sufficient to diagnose it. METHODS: The clinical data and colorectal biopsy specimens from 38 patients with collagenous colitis were studied. In 10, small bowel biopsy specimens were also available for review. Immunostaining of the mucosal lymphoid infiltrate with a panel of relevant antibodies was carried out on formalin fixed tissue in seven cases; in three the phenotyping was performed on fresh biopsy specimens separately frozen or fixed in B5 solution. RESULTS: Coeliac disease was found in four out of the 10 patients with collagenous colitis who had had a small bowel biopsy, in contrast to the prevalence of the disease in Australia of 1 in 3000. Collagenous colitis did not respond to gluten withdrawal. Five of 29 (17%) of the patients had a mixed pattern of lymphocytic and collagenous colitis. Immunostaining of the lymphoid infiltrate showed that the striking increase in intraepithelial lymphocytes in collagenous colitis was due to an influx of CD8 positive cells. The occurrence and severity of collagenous colitis along the large bowel were independent of the anatomical site, and in more than 90% of cases biopsy specimens from the sigmoid colon or rectum were diagnostic. CONCLUSIONS: There is a very high incidence of coeliac disease among patients with collagenous colitis so that jejunal biopsy should be an essential part of their investigations, especially if symptoms persist. However, only a minority showed a mixed pattern of lymphocytic and collagenous colitis. The intraepithelial lymphocytes in collagenous colitis are CD8 positive cells. Collagenous colitis can be diagnosed from rectal or sigmoid colon biopsy specimens in more than 90% of cases.

Adult↗
PubMed1991

Phosphorylation sites of the nicotinic acetylcholine receptor. A novel site detected in position delta S362.

The delta-subunit of the nicotinic acetylcholine receptor from Torpedo californica electric tissue isolated form receptor purified in the absence of protein phosphatase inhibitors contains a total of four phosphate groups. Three of these are shown to represent phosphoserine groups. The fourth possible represents phosphotyrosine. The phosphate groups are localized within the primary structure: We found phosphoserine in positions delta S361 and delta S377, the predicted sites phosphorylated by PKA and PKC, respectively. In addition, we found that position delta S362 is also phosphorylated. Phosphorylation experiments with the synthetic peptide delta L357-delta K368 show that phosphorylation of this novel site can be catalyzed by PKA and by PKC. It is concluded that the delat-subunit of the acetylcholine receptor is stably and not transiently phosphorylated. Implications for the physiological functions of receptor phosphorylation are discussed.

Animals↗
PubMed1991

[The OFFER self concept questionnaire for adolescents and the success of inpatient psychotherapy].

The OFFER-Self-Image-Questionnaire reflect psychotherapeutic effects under special conditions. The OFFER-Self-Image-Questionnaire was used to evaluate outcome of in-patient psychotherapy in 15 adolescents. An increase of 8 or more points on the standard scale between the first and fourth week was associated with favourable outcome while an increase of 7 or less points indicated less favourable outcome.

Adolescent↗
PubMed1990

Identification of phosphopeptides by mass spectrometry.

Phosphopeptides can be identified by ion spray mass spectrometry. The method was tested with phosphokemptide and with a proteolytic digest of one subunit (delta-subunit) of the nicotinic acetylcholine receptor. In the latter one peptide containing tyrosine phosphate, one with two serine phosphates, and two different peptides each containing one serine phosphate were unambiguously identified. Thus it is proven that ion spray mass spectrometry can be applied for the localization of phosphorylation sites in a known primary structure.

Chromatography, High Pressure Liquid↗
PubMed1990

[Health behavior and cardiovascular risk factors in females in relation to their marital status].

This is an overview of the literature analysing the international level of knowledge about the influence of marital status on the prevalence of cigarette smoking, hypertension, hyperlipoproteinemia, obesity, alcohol consumption and type-A-behavior of women. An accumulation of the more behavior-dependent risk factors cigarette smoking and alcohol consumption was found by divorced and of the obesity by never married women. Widowed women scarcely differ from women in other marital status groups in their risk factor profile. The risk factors hypertension and hyperlipoproteinemia hardly correlate with the marital status. The overcome-behavior by loading is discussed as one possible cause of the found correlations. That's why family and social support has got a preventive consequence.

Adult↗
PubMed1989

Synchronous tumors arising in a single major salivary gland.

Multiple separate tumors arising in the major salivary glands are distinctly unusual. The records on 25 patients with synchronous unilateral salivary gland tumors on file at St Louis University and at the Armed literature. Bilateral tumors arose more frequently than multiple unilateral ones. The most common tumors with bilateral synchronous or metachronous development are the Warthin tumors, with more than 100 reported cases; the mixed tumor with at least 34 cases; and the acinic cell carcinoma, with 12 reported cases. The Warthin tumor also was the most likely to present with multifocal unilateral involvement with 29 tumors having three or more separate foci of tumor. The next most common tumor combinations are a Warthin tumor and a mixed tumor (20 cases), the multifocal membranous basal cell adenoma (12 cases), and multiple oncocytomas (nine cases). Numerous other tumor combinations were found covering the range of salivary gland neoplasia, however one of the tumors usually was a mixed tumor or a Warthin tumor.

Adult↗
PubMed1989

[Rotation auto-keratoplasty. Preoperative calculation].

A formula is given with which it is possible to calculate preoperatively the size of the eccentric trepanation in rotation autokeratoplasty and the resulting optimized visual center. On the patient's eye the position of the visual axis on the cornea, and the distance between this and the edge of the scar and the corneal limbus must be measured in the meridian where the scar extends least over the visual axis. The calculation can be performed very quickly with the aid of a diagram based on the formula r = 0.25(3R-x-2).

Corneal Opacity↗
PubMed1987

The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.

The human myeloperoxidase (MPO) gene has recently been cloned in our laboratory. Southern blot hybridization of our MPO cDNA to DNA from a somatic cell hybrid clone panel revealed that the MPO cosegregated with human chromosome 17. In situ hybridization mapped the MPO gene to chromosome 17q22-24. Although this location is close to the translocation breakpoint which occurs in acute promyelocytic leukemia (APL), t(15;17)(q22;q21-22), Southern blot hybridization with different restriction-digested genomic DNA samples from four APL patients did not reveal MPO gene rearrangement. However, RNA dot-blot hybridization showed that APL patients with the translocation expressed high levels of MPO mRNA. This observation raises the possibility that the high levels of MPO gene expression in APL could be due to the arrest of leukemic cells at a specific stage of differentiation or a consequence of the translocation.

Chromosome Mapping↗
PubMed1987

[The square search test in connection with acoustic evoked brain stem potentials].

A random sample of 15 patients suffering from multiple sclerosis without acute episodes and at least partially able to work, shows to a high degree of statistical certainty that reduction in amplitude of acoustically evoked brain stem potentials (BAEP) is closely linked with beta-weighted performance value of the square search test (QSP).

Brain Stem↗
PubMed1985

Amino-acid sequence of human and bovine brain myelin proteolipid protein (lipophilin) is completely conserved.

Proteolipid protein (PLP) was isolated from white matter of human brain by chloroform/methanol extraction and further purified by chromatography. Performic acid oxidation yielded a product homogeneous in NaDodSO4-polyacrylamide electrophoresis with a molecular mass of 30 kDa. The carboxymethylated PLP was chemically cleaved with cyanogen bromide into four fragments: CNBr I 22-24 kDa, CNBr II 5 kDa, CNBr III 1.4 kDa and CNBr IV 0.7 kDa. HBr/dimethylsulfoxide cleavage at tryptophan residues released four fragments: Trp I 14-16 kDa, Trp II 2.0 kDa, Trp III 5 kDa and Trp IV 7 kDa. Hydrophilic fragments were enriched in 50% formic acid (CNBr II, III, IV and Trp II and III), whereas hydrophobic peptides precipitated from this solvent were CNBr I, Trp I and IV. The fragments were separated by gel filtration with 90% formic acid as solvent and finally purified by gel permeation HPLC (Si 60 and Si 100) for automated liquid and solid-phase Edman degradation. Large fragments were further cleaved with different proteinases (trypsin, V8-proteinase, endoproteinase Lys-C and thermolysin). We used an improved strategy in the sequencing of the human proteolipid protein compared with our approach to the structural elucidation of bovine brain PLP. The amino-acid sequence of human PLP contains 276 residues, the same as found in bovine proteolipid protein. The two sequences proved to be identical. The possible importance of the conservative structure of this integral membrane protein is discussed.

Amino Acid Sequence↗