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Biomedical subjects

W Sieber

Publications and source records attributed to W Sieber.

9 recordsLinked to original sources
PubMed2001

A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer.

OBJECTIVE: To evaluate whether baseline or procedural stress during in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT) affects pregnancy or live birth delivery rates. DESIGN: Prospective study. SETTING: Seven clinics in Southern California between 1993 and 1998. PATIENT(S): One hundred and fifty-one women completed two questionnaires. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The number of oocytes aspirated and fertilized, the number of embryos transferred, the achievement of a pregnancy, live birth delivery, and infant outcomes. RESULT(S): Positive-affect negative-affect score at baseline negatively influenced the number of oocytes retrieved and embryos transferred. A higher expectation of pregnancy was associated with greater numbers of oocytes fertilized and embryos transferred. At baseline, the risk of no live birth was 93% lower for women who had the highest positive-affect score compared to those with the lowest score. Furthermore, the score on the Infertility Reaction Scale was related to negative outcomes in live birth delivery, infant birth weight, and multiple births. During the time of the procedure, the PANAS and Bipolar Profile of Moods States results were related to the number of oocytes fertilized and embryos transferred; stress did not affect pregnancy or delivery. CONCLUSION(S): Baseline (acute and chronic) stress affected biologic end points (i.e., number of oocytes retrieved and fertilized), as well as pregnancy, live birth delivery, birth weight, and multiple gestations, whereas (procedural) stress only influenced biologic end points.

Adaptation, Psychological↗
PubMed2000

Adherence to pharmacological interventions. Current trends and future directions. The Pharmacological Intervention Working Group.

The complexity of adherence to pharmacological interventions is frequently underestimated. Consequently, little research has been done to understand, improve, or evaluate the effects of adherence to drug protocols. While efforts to better measure and increase adherence require dedicated resources, improved adherence in existing clinical research can potentially cut costs in trial size and length. This paper outlines strategies to facilitate research on adherence to pharmacological interventions including: reporting of adherence data, changing how we conceptualize adherence to pharmaceuticals, understanding issues unique to older adults' pill-taking behavior, and creating standardized methodologies to measure adherence. Further, we describe some promising research areas that may lead to effective interventions: adherence "typologies" and modality matching. Control Clin Trials 2000;21:218S-225S

Aged↗
PubMed1988

Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.

Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: (Formula: see text).

Allergens↗
PubMed1976

Sequestration of the lung in children.

Nine cases of sequestration of the lung were seen in children. Bronchopulmonary sequestration of the lung is a distinct congenital anomaly and clinical entity that can be distinguished from other congenital abnormalities of the lung. Such a congenital anomaly must be considered in children who, on roentgenologic examination, are found to have an opacity in the lower lung fields. Intralobar bronchopulmonary sequestration often is associated with recurrent pulmonary sepsis, whereas extralobar sequestration is less likely to be symptomatic and usually exhibits no abnormal physical findings. In a unique case, we found an extralobar sequestration associated with an esophageal duplication that communicated with the sequestered lobe but not with the esophagus. This situation represents a transitional stage in embryonic development of extralobar sequestration. Intralobar and extralobar forms of sequestration show many common characteristics indicating a common embryogenesis. Surgical excision, consisting of lobectomy or segmentectomy, is safe and effective and may be accomplished without morbidity or mortality.

Age Factors↗