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Biomedical subjects

W Siegmeth

Publications and source records attributed to W Siegmeth.

35 records · Page 2Linked to original sources
PubMed1975

[Complications in chloroquin therapy].

Chloroquine and hydroxychloroquine are widely used in diseases of connective tissue, especially in rheumatoid arthritis and systemic lupus erythematosus. However, various side effects are reported in many publications. In general these side effects are less important, e.g. those on the gastrointestinal tract and drug exanthema. Disorders of the haemopoetic system, the central nervous system, and peripheral neuromyopathy are rare. Only few reports exist about fetal damage. In contrary, severe problems result from eye complications such as reversible keratopathy and mostly irreversible retinopathy. If, however, chloroquine is administered, the necessity of exakt dosage and periodic ophthalmologic controls has to be stressed.

Arthritis↗
PubMedDate not supplied

Night pain and morning stiffness in osteoarthritis: a crossover study of flurbiprofen and diclofenac sodium.

Forty patients took part in an observer-blind multiple dose crossover study to compare the efficacy and tolerability of 300 mg flurbiprofen (100 mg twice a day orally and 100 mg suppository at night) with 75 mg diclofenac sodium (25 mg twice daily orally and 25 mg suppository at night) in the relief of night pain and morning stiffness in patients with osteoarthritis. Equal numbers of patients were randomized to receive one of the treatments for the first 7-day treatment period and then the other treatment for the second 7-day treatment period. There were significant differences in favour of flurbiprofen for the reduction in night pain, improvement in quality of sleep and patients' assessment of overall improvement on treatment. Two patients withdrew from the study due to side-effects experienced whilst taking diclofenac sodium during the first treatment period. Eight patients in all reported a total of 18 side-effects during this study. Six patients reported 12 side-effects whilst taking diclofenac sodium compared with three patients who reported six side-effects whilst taking flurbiprofen. This study confirms the good efficacy and tolerability of flurbiprofen in the symptomatic relief of osteoarthritis.

Adolescent↗
PubMedDate not supplied

[Fibronectin and other immunologic parameters in chronic polyarthritis].

In 20 patients with rheumatoid arthritis the plasma fibronectin concentrations were measured and correlated with the levels of C-reactive protein, alpha 1-antitrypsin, alpha 2-macroglobulin, fibrinogen, C3, C4 complement fractions and alpha 2-antiplasmin in serum respectively plasma. Patients with rheumatoid arthritis showed plasma fibronectin concentrations within reference levels. However, the concentrations of C-reactive protein, alpha 1-antitrypsin, alpha 2-antiplasmin, fibrinogen and C3-complement fraction were significantly higher in comparison to the healthy controls. The results indicate that fibronectin does not belong to the group of "acute phase proteins". Measurement of plasma fibronectin give no additional information about the activity of rheumatoid arthritis.

Adult↗
PubMedDate not supplied

[Comparison of glycosaminoglycan polysulfate (Arteparon) and physiological saline solution in arthrosis of the large joints. Results of a multicenter double-blind study].

In a double-blind study, glycosaminoglycan polysulfate (GAGPS, Arteparon) was compared to saline solution: both preparations were applied intramuscularly in two groups of 70 patients, each over a period of 8 weeks. The patients were suffering from pain and impaired function of the knee and hip joints. To assess the therapeutic efficacy, the following parameters were employed: pain, joint mobility, and walking distance. The post trial observation period lasted for 6 months. In the GAGPS group, a statistically significant improvement compared to the results in the saline group was noted during the 2nd and 6th months of observation respectively. The global assessment by investigator and patient at the end of the observation period was superior in the GAGPS group to that in the saline group. While the difference regarding the onset of pain remission between the GAGPS and the saline groups was insignificant, the rate of complete relief from pain was better in the GAGPS group, and pain worsened in fewer incidences in this group, too. Laboratory findings did not reveal any detrimental effect of either treatment with respect to hematology, blood chemistry, or urinalysis. 3 patients of the GAGPS group developed harmless hematomas of short duration at the site of injection.

Adult↗
PubMedDate not supplied

Oral gold therapy with auranofin (SK&F 39162). A multicenter open study in patients with rheumatoid arthritis.

One hundred and fifty patients with rheumatoid arthritis received 6 mg of auranofin daily for 2-24 months. Thirty patients were withdrawn from the study, and 82 patients were observed for 12 months. Statistical evaluation was available for 74 patients at weeks 24, 38, and 48, respectively. The major side effects observed were diarrhea, rash, and alopecia. Significant improvement was noted in the articular index, ESR, pain, and morning stiffness.

Administration, Oral↗
PubMedDate not supplied

[Diflunisal in the treatment of hip and knee joint arthroses].

Diflunisal (Fluniget, MK-647) was tested in an open clinical study with regard to its analgesic effect and its improvement of function in 30 patients suffering from osteoarthrosis of the hip and the knee. The treatment lasted for 4 weeks. The therapeutic effect was judged by the influence on day and night rest pain and on pain from pressure and movement, the change of morning stiffness and the functional improvement. Further judgement included general assessment by the physician and the patients. With Diflunisal the majority of the patients achieved a lasting improvement of their condition. A marked analgesic effect was observed during the first two weeks of therapy. Diflunisal was well tolerated. Laboratory data at the beginning and at the end of the four week treatment period revealed no toxic effects on organs, particularly no hematotoxic effects.

Adult↗
PubMedDate not supplied

[Calcium-phosphate metabolism in chronic polyarthritis].

20 patients suffering from rheumatoid arthritis were studied to evaluate both, radiological and scintigraphic osseous changes, as well as possible disturbances in calcium phosphate metabolism. Joint and osseous alterations were assessed in all of them. Serum levels of magnesium, calcium, phosphate and alkaline phosphate were within the normal range, and also concurrent measurements of serum 25-OH-D3 concentrations and plasma levels of parathyroid hormone (PTH). However, in our patients with normal renal function, the plasma concentration of calcitonin (CT) was significantly elevated compared to normals (p less than 0.01). Our data indicate that in patients studied PTH and 25-OH-D3 does not contribute to the development and progression of osseous changes due to rheumatoid arthritis. Possibly the stimulatory effect of various osteolytic factors may cause as counterbalance elevations in plasma CT levels.

Adult↗