Biomedical subjects

W Skwara

Publications and source records attributed to W Skwara.

7 recordsLinked to original sources

PubMed2005

Transcatheter closure of a ruptured ventricular septum after myocardial infarction using a venous approach.

A 65-year old patient was admitted after having sustained a ventricular septum rupture 18 days after an anterior myocardial infarction. He developed acute heart failure. Given the extremely high perioperative risk in surgical approaches in this setting, we decided for a transcatheter closure of the defect with an exclusively venous approach. After a complete recovery, the patient underwent open heart surgery with aorto coronary bypass, aneurysmectomy, and removal of the closure device. This case demonstrates that transcatheter closure of a post infarction ventricular septum rupture is a technically feasible and suitable method.

Aged↗

PubMed2000

[The maze operation--surgical therapy of chronic atrial fibrillation: modification to mini-maze operation].

OBJECTIVE: Atrial fibrillation (AF) is the most common arrhythmia. However, its precise electrophysiologic mechanism is still not well understood. Chronic symptomatic atrial fibrillation resistant to medical therapy can successfully be treated by the Maze III procedure (M III). Several publications are dealing with alternative surgical techniques. This study describes technique and midterm results of a Mini-variant (Mini) of the Maze III procedure. METHODS: During a 48-month period we performed either a M III (group I = 7 patients) or a Mini-Maze operation (group II = 65 patients) in 33 males and 39 females with chronic symptomatic atrial fibrillation and additional cardiac pathology. Patients were controlled 4.0 +/- 1.8 months (group I) respectively 3.6 +/- 0.8 months (group II) (NS) and 16.75 +/- 2.5 months (group I) respectively 13.2 +/- 1.9 months (group II) (NS) after operation by means of thorough electrophysiological assessment, right heart catheterization, MRI, echocardiography, stress-ECG and 24 h-ECG. RESULTS: There was no significant difference between the two groups with regard to sex, age and duration of AF. Echocardiographic left atrial diameter (LAD) was 75 +/- 11 mm in group I and 65 +/- 8 mm in group II (p = 0.002). Whereas right atrial diameter was 62 +/- 8 mm in group I and 57 +/- 7 mm in group II (NS). Perioperative data (n = 72): Aortic cross clamp time was 127 +/- 40 min in group I and 87 +/- 22 min in group II (p = 0.0002). Cardiopulmonary bypass time was 185 +/- 71 min in group I and 137 +/- 42 min in group II (p = 0.01). Postoperative data I (first follow-up: n = 66): sinus rhythm (yes): 4/7 vs. 47/59 (NS); pacemaker (PM) in AAI mode (yes): 1/7 vs. 3/59 (NS); inducible atrial fibrillation (yes): 2/7 vs. 5/59 (NS); Bradycardie Tachycardie Syndrome with the need of PM implantation 0/7 vs. 4/59 (NS). Postoperative data II (second follow-up: n = 55): sinus rhythm (yes): 5/7 vs. 34/48 (NS); PM in AAI mode (yes): 0/7 vs. 4/48 (NS); Inducible atrial fibrillation (yes): 2/7 vs. 5/48 (NS); Bradycardia Tachycardia Syndrome with the need of PM Implantation 0/7 vs. 5/48. CONCLUSION: Midterm results are identical after M III and Mini. The Mini-Maze procedure is less complex compared to the Maze III procedure and there is a significant reduction of crossclamp and ECC times. We recommend the Mini especially for polymorbid patients and for those with poor left ventricular function.

Adult↗

PubMed2000

Do patients want minimally invasive aortic valve replacement?

OBJECTIVE: Access to aortic valve can be performed through small incisions. However, a considerable advantage of this approach has not been proven by randomized studies so far. We wanted to elucidate the opinion of patients when they are informed objectively about advantages and disadvantages of minimally invasive approach prior to operation. METHODS: This prospective study was performed with 27 patients undergoing isolated aortic valve replacement. These patients were informed prior to operation by the same resident concerning objective data. A photograph was shown illustrating a patient with postoperative wound after a standard- and a mini-incision, respectively. After the interview the patient could decide between full and partial sternotomy. RESULTS: After the interview 21/27 (78%) patients preferred to have a full sternotomy (group F) and 6/27 (22%) patients (group P) decided to have a partial sternotomy. Comments of group F: surgeon should have best exposure (n=15); cosmetics aspects unimportant (n=14); operation time as short as possible (n=7). Group P: cosmetic aspects important (n=6). Significant differences between groups (group F vs. group P): age (years), 69.1+/-1.5 vs. 49.2+/-7.3 (P=0.024); operation time (min), 142+/-7 vs. 189+/-15 (P=0.002); CK (IU/l), 111+/-11 vs. 374+/-114 (P=0.0007); CKMB (IU/l), 17+/-2 vs. 45+/-17 (P=0.006); ICU-stay (days), 2.6+/-0.2 vs. 3.2+/-0.2 (P=0.044). Pericardial effusion requiring drainage was observed in two patients of group P. One patient of group P suffered myocardial infarction. CONCLUSION: When patients are informed objectively about advantages and disadvantages of minimal invasive aortic valve surgery only a smaller number decides to have a mini incision. The patients preferring short incisions are significantly younger since cosmetic aspects are more important. Longer duration of operation may be due to longer hemostasis based on limited exposure. Air bubbles due to inadequate de-airing might be responsible for higher CK and CK-MB levels in group P.

Adult↗

PubMed2000

A self-perpetuating vicious cycle of tissue damage in human hibernating myocardium.

Recently, we proposed the hypothesis that a vicious cycle exists in human hibernating myocardium (HM) between the progression of myocyte degeneration and the development of fibrosis. We now investigated the pathomechanism of this cycle in more detail and established a correlation between the severity of the morphological changes and the degree of postoperative functional recovery of HM. HM was diagnosed by dobutamine echocardiography, thallium-201 scintigraphy and radionuclide ventriculography. Functional recovery was present at 3 months after coronary bypass surgery but remained unchanged at 15 months. Forty patients were subdivided into 2 groups: A with complete and B with incomplete recovery. Biopsies taken during surgery and studied by electron microscopy, immunocytochemistry, rt-PCR, and morphometry revealed myocyte degeneration and inflammatory and fibrinogenic changes in a widened interstitial space. We report here for the first time an upregulation of TGF-beta1 evident by a 5-fold increase of fibroblasts and macrophages exhibiting a TGF-beta1 content 3-fold larger than in control, and a > 3-fold increase in TGF-beta1 mRNAby rt-PCR. The number of angiotensin converting enzyme (ACE) containing structures was increased (n/mrm2: control-11.4, A-17.6, B-19.2, control vs. A and B, p < 0.05). Fibrosis was more severe in group B than A or control (%: C-10.1; A-21.2; B-40.6; p < 0.05). Capillary density was significantly reduced (n/mm2: C-1152; A-782; B-579, p < 0.05) and intercapillary distance was widened (microm: C-29.5, A-36.1, B-43.3, p < 0.05). The number of CD 3 (n/mm2: C-5.0; A-9.6; B-9.4, ns) and CD 68 positive cells (n/mm2: C-37.2; A-80.7; B-55.0, C vs. A p < 0.05) was elevated in HM as compared to control indicating an inflammatory reaction. Cut-off points for functional recovery are fibrosis > 32%, capillary density < 660/mm2 and intercapillary distance > 39.0 microm. In HM a self-perpetuating vicious cycle of tissue alterations leads to progressive replacement fibrosis and continuous intracellular degeneration which should be interrupted by early revascularization.

Adult↗

PubMed1999

Cardioscopy: potential applications and benefit in cardiac surgery.

OBJECTIVE: Cardioscopy in open heart surgery is still not routine in most units. However, since our first report in 1996 we use this device more frequently, because we think that safety and accuracy of different surgical procedures is increased. METHODS: Between 1/96 and 12/97 we performed cardioscopy in 100 patients. Indications (IND) for cardioscopy were as follows: IND (1) resection of hypertrophied septum (N = 15); IND (2) evaluation of aortic valve with low grade stenosis or insufficiency (N = 12); IND (3) removal of intracardiac foreign bodies/tumors (N = 13); IND (4) inspection of VSD prior and after repair (N = 8); IND (5) identification of paravalvular leakage (N = 8); IND (6) diagnostic purposes (N = 4); IND (7) education of surgeons and operating room staff (N = 40). During cardioplegic arrest the 5 mm rigid or flexible cardioscope (Storz, Tuttlingen, Germany) was inserted through ascending aorta, aortic valve or tricuspid valve depending on indication. RESULTS: No complication occurred during cardioscopy. IND (1): there was an excellent view of all intracardiac structures. Thorough resection of hypertrophied septum was possible and there was no injury of adjacent structures or aortic valve. IND (2): all valves were inspected through a 1 cm aortic incision and the pathology of the valves was documented. In case of severe calcification, the valve was replaced although transvalvular gradient was less than 50 mm Hg. IND (3): intraventricular foreign bodies, such as felt pledges (N = 2), debris (N = 5), thrombi (N = 4) and tumors (N = 2) were entirely removed through the aortic valve with a special forceps. IND (4): anatomy of VSD was documented in all cases. It was possible to test accuracy of all patch-sutures. IND (5): all paravalvular leakages were identified even though there was heavy immobility of the mechanical valve. IND (6): a papillary muscle (N = 2) and a thrombus formation (N = 2) were diagnosed. IND (7): the surgeons and operating room staff could follow the entire procedure in all cases. CONCLUSIONS: Cardioscopy is a supporting technique to clearly identify intracardiac structures, to control several surgical procedures, to document valve pathology, and to educate surgeons and operating room staff. Handling is easy and does not increase operative risk. Some procedures will be performed with minimal invasivity in future.

Aortic Valve Stenosis↗

PubMed1999

Midterm results after the Mini-Maze procedure.

OBJECTIVE: Atrial fibrillation (AF) is the most common arrhythmia. However, its precise electrophysiologic mechanism is still not well understood. Chronic symptomatic AF resistant to medical therapy, can successfully be treated by the Maze III procedure (M III). However, there are several publications dealing with alternative surgical techniques. This study describes technique and midterm results of a Mini-variant of the M III procedure. METHODS: During a 38-month period we performed either an M III (seven patients) (group I) or a MINI-operation (45 patients) (group II) with chronic symptomatic AF and additional cardiac pathology. Patients were controlled 3.6 +/- 0.9 and 14.9 +/- 2.2 months after operation by means of thorough electrophysiological assessment, right heart catheterization, magnetic resonance imaging (MRI), echocardiography, stress-EGG and 24-h-ECG. RESULTS: There was no significant differences between the two groups with regard to sex, age and duration of AF. Echocardiographic left atrial diameter (LAD) was 75 +/- 11 mm in group I and 67 +/- 8 mm in group II (P = 0.01). Whereas right atrial diameter was 62 +/- 8 mm in group I and 56 +/- 7 mm in group II (NS). Perioperative data (n = 52): aortic cross clamp time was 127 +/- 40 mm in group I and 87 +/- 21 mm in group II, (P = 0.0002). Cardiopulmonary bypass time was 185 +/- 71 mm in group I and 137 +/- 46 mm in group II, (P = 0.02). Postoperative data: there was no difference between the two groups with regard to sinus rhythm, prolonged sinus node recovery time, pacemaker (PM) in AAI-mode, inducible atrial fibrillation, reduction of left and right atrial size after a follow-up interval of 3.6 months and 1 year, respectively. CONCLUSION: Midterm results are identical after M III and MINI. MINI is less complex compared to the M III procedure and there is a significant reduction of crossclamp- and ECC-time. We recommend the MINI especially for polymorbid patients, and for those with poor left ventricular function.

Adult↗

PubMed1997

Video-assisted resection of hypertrophied and fibrous intraventricular tissue.

There is increasing interest in endoscopic techniques in cardiac surgery. However, use of the endoscope during open heart operations is still not routine. Cardioscopy has been used in patients with hypertrophied obstructive cardiomyopathy, asymmetric septal hypertrophy, or membranous subaortic stenosis. We demonstrate the resection of this pathologic tissue under direct visualization. With this technique we could increase the safety and accuracy of this surgical procedure. Beside this advantage, the entire operating room staff could follow the surgical intervention, which increases its educational side-effect.

Cardiomyopathy, Hypertrophic↗