PubMed Health⌕ Search

Biomedical subjects

W Stögmann

Publications and source records attributed to W Stögmann.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Manifestation of glucose-6-phosphate dehydrogenase deficiency caused by primaquine in malaria therapy].

This is a report about a 9 year old turkish boy suffering from recurrent episodes of high fever caused by Plasmodium vivax-infection (Malaria tertiana), 12 months after returning from his malarious homeland. After a 3-day course of Chloroquin, we administrated Primaquin to eliminate residual extraerythrocyte forms of Plasmodium vivax. On the 7th day of treatment acute haemolysis developped. This was caused by Glucose-6-Phosphate-Dehydrogenase-Deficiency, which could be demonstrated by a red-cell-enzyme analysis. The investigation of the patient's whole family showed the typical recessive X-linked inheritance of this enzyme-defect. Frequency and clinical manifestations of this defect are discussed.

Child↗
PubMed1983

[Elevated prolactin reserves in gonadal dysgenesis and agonadism].

Prolactin-reserve before and after TRH-stimulation was studied in 12 patients with gonadal dysgenesis and 2 children with agonadism. 7 patients (50%) had moderately increased basal PRL levels and 13 (93%) showed exaggerated PRL-responses to TRH at 30 min. The increased prolactin-reserve was independent of age and karyotype of our patients. Cause and significance of this observation remains to be clarified. It is speculated that elevated PRL-levels could be only a side-effect of hypergonadotropism in hypo- and agonadal subjects.

Adolescent↗
PubMed1983

[Disorders of calcium metabolism and ossification caused by anticonvulsants].

Disturbances of Calcium-metabolism and of ossification are well known and well documented side-effects of anticonvulsant drugs since the first description in 1967. Elevated alkaline phosphatase and hypocalcemia till generalised osteoporosis and vitamin-D-sensitive rickets can be seen. The primary cause of these dose-related disturbances is an accelerated elimination of vitamin D because of induction of microsomal enzymes in the liver by anticonvulsant drugs; a suboptimal vitamin-D-intake and reduced sunlight exposure in institutionalised patients are often combined causative factors. In all patients treated with anticonvulsant drugs a sufficient supplementation with vitamin D is necessary.

Alkaline Phosphatase↗
PubMed1982

[Acute emergency diseases in childhood - emergency measures in practice].

The immediate management of three kinds of emergencies in childhood-unconsciousness, convulsions and acute respiratory failure-is discussed. First of all and in any case it is necessary to assess and reestablish vital, especially cardiorespiratory functions. Most common causes of unconsciousness in young children are dehydration states and acute poisoning, followed by febrile convulsions. Differential diagnosis and first management of subglottic laryngitis and peracute epiglottitis, two severe acute respiratory failures in childhood, are also demonstrated.

Adolescent↗
PubMed1982

[Mycoplasma pneumoniae-pneumonia in childhood (author's transl)].

A report is given about 64 cases of mycoplasma pneumoniae-pneumonia in childhood. Distribution of the patients age, seasonal frequency of occurrence and clinical, radiological, and laboratory findings are mentioned, also complications and concomitant manifestations of the illness. At present mycoplasma pneumoniae-pneumonia is endemic in Austria and the most frequent kind of pneumonia in children of school age and adolescents. Epidemiology and possibilities of prophylaxis are discussed.

Adolescent↗
PubMed1982

[Salmonella enteritis in childhood - a tropical problem (author's transl)].

148 children with Salmonella gastroenteritis were admitted to the Mautner Markhofsches Kinderspital of Vienna in the 4-year period 1977 to 1980. The age distribution showed a marked prevalence of infants and young children. Salmonella Wien, typhi murium and enteritidis were the most commonly found Salmonella subtypes. No complications were encountered. After an average stay in hospital of 9 days the patients were considered fit for discharge, although only one third had negative stool cultures, whilst two thirds were convalescent Salmonella excretors. The duration of Salmonella excretion showed a hyperbolic course and was dependent on various factors, but could not be shortened by antimicrobial treatment. The topical problems of Salmonella gastroenteritis are discussed: the age distribution, with the highest incidence in early childhood, the duration of excretion in relation to antimicrobial treatment, the arguments against routine antibacterial treatment, the increase in Salmonella gastroenteritis in Western countries over the past years and the cause of this increase based on the high contamination rate of meat from animals infected by contaminated fodder. Large canteens are particularly vulnerable.

Ampicillin↗
PubMed1982

Prolactin and thyrotrophin response to thyrotrophin-releasing hormone in growth hormone deficiency.

Basal and thyroid-releasing hormone-stimulated (200 micrograms/m2) prolactin and thyroid-stimulating hormone (TSH) levels were measured in 31 patients with hypopituitarism (13 isolated growth-hormone deficiencies and 18 multiple pituitary hormone deficiencies). The results were compared with the prolactin response in 76 healthy prepubertal children. Normal prolactin concentrations were found in 13 patients whereas 11 had increased levels. TSH levels were either normal or increased in patients who were considered to have hypothalamic disorders. Decreased prolactin response was present in 7 children, 6 of whom had multiple pituitary deficiencies. Their TSH response was decreased as well, indicating pituitary failure. There was good overall correlation of peak prolactin with peak, TSH concentrations. Some patients with 'isolated' growth hormone deficiency had an abnormal prolactin response indicating an additional hormonal deficiency. All patients with low levels of serum thyroxine had abnormal prolactin or TSH levels, high in some, low in others. Two euthyroid patients with increased prolactin stimulation became hypothyroid during treatment with growth hormones, thus questioning whether prolactin is a more sensitive indicator of early thyroid insufficiency than thyroxine or TSH levels.

Adolescent↗
PubMed1982

[Attempted suicide in children: suicidal development (author's transl)].

This is a report about 21 children, aged 10 till 15 years, who were admitted between 1977--1980 in a children's hospital because of attempted suicide. Exploration of the psychosocial situation and psychological tests brought many common factors of the suicidal development; a nonfunctioning relationship among the members of the family was the basal cause of a disturbed development of personality. This was responsible for failure in school, what was the cause for further problems in the family. There were many signs and symptoms of a presuicidal situation in each case, but in no one this was recognized by family or school.

Achievement↗
PubMed1981

[Pseudohypoparathyroidism with hypothyroidism (author's transl)].

This is a report about three children suffering from pseudo-hypoparathyroidism type I and moderate primary hypothyroidism. The thyroid dysfunction was characterised by slightly low plasma thyroxine and high basal TSH showing an increased response to TRH. T3 and rT3 were within normal limits, the size of the thyroid glands and also bone age were normal. The plasma concentrations of T4 and TSH and the response of TSH to TRH were no different during hypocalcemia from those obtained in normocalcemia during vitamin D treatment. Thyroxine treatment could normalize T4 and TSH. Moderate hypothyroidism is frequently present in pseudohypoparathyroidism. It has to be assumed that the same genetical defect of the second messenger, already proved to exist in the kidneys of patients with pseudohypoparathyroidism may also exist in the thyroid gland.

Adolescent↗
PubMed1980

[Normal values for circulating thyroid hormones, T3 uptake and thyrotropin before and after TRH. Radioimmunoassay determinations on 182 euthyroid children (author's transl)].

Measurements of T4, T3, rT3, T3U, and TSH (before and after TRH stimulation) were performed by RIA. 182 children, apparently euthyroid, age 2/12--14 years, were investigated in a cross sectional study. Free T4RIA and free T3RIA Indices and the ratio rT3/T3 and T4/T3 were calculated. Statistical analysis showed the following results: 1. Geometric mean serum concentrations of T4, T3, rT3 and TSH (basal) show no age related differences; T4 showed a not significant negative slope with age.--2. The ratio rT3/T3 and T4/T3 remains constant.--3. TRH induced TSH release (indicating the activity of the regulatory system) is unchanged from 2/12 to 14 years. Geometric means values, standard deviations and normal ranges are given.

Adolescent↗
PubMed1980

[Insulin antibody formation in diabetic children (author's transl)].

This is a report about the findings of insulin antibody formation (circulating IgG-antibodies) in 18 diabetic children. 1. High levels of antibodies during treatment with conventional insulin show a remarkable decrease under treatment with highly-purified insulins. 2. Insulin binding capacities were also found in children treated from diagnosis of the disease with highly-purified insulins, but they were all below 1.0 mU/ml. 3. Infectious diseases and intermittent insulin application seem to provoke an, at least briefly, increase of antibodies. 4. High levels of antibodies cause a high insulin requirement. Therefore only highly-purified insulin should be used for the treatment of childhood onset diabetes mellitus.

Antibodies↗
PubMed1980

[Campomelic syndrome].

A case of campomelic syndrome, the first one in Austria, is described. This syndrome, known since 1971, is characterised by congenital shortening and bowing of long bones, with pretibial skin dimples, other abnormalities of bones, and spine prenatal dwarfism, kraniofacial dysmorphia and malformations of heart, kidney and brain. Death in the neonatal periode or in early infancy is the rule. An autosomal recessive mode of inheritance is discussed.

Abnormalities, Multiple↗
PubMed1979

[Disturbances of calcium-phosphate-metabolism by anticonvulsant drugs in relation to their serum concentration (author's transl)].

25.6% of 254 epileptic children receiving anticonvulsant drugs more than 3 years showed disturbances of Calcium-phosphate-metabolism and of ossification respectively. These disturbances are divided into 4 degrees of severity: 1. Raised alkaline phosphatase in serum alone 21 patients); 2. Metaphysial osteodystrophia (22 Pat.); 3. Generalised osteoporosis (16 Pat.) and 4. Vitamin-D sensitive rickets (6 Pat.). These abnormalities were found at most in long term-treatment with hydantoins or primidone. The measurement of serum concentration of these anticonvulsant drugs yielded significantly higher amounts in patients with abnormalities in Calcium-Phosphate-metabolism than in those patients without such ones. This result permits us to conclude that disturbances of Calcium-Phosphate-metabolism are serum-concentration-dependent side-effects of anticonvulsant drugs.

Adolescent↗
PubMed1979

[Immunosuppressive treatment of endogenous uveitis in childhood (author's transl)].

This report is about a seven year old boy suffering from endogenous uveitis of unknown etiology in both eyes. A local and systemical steroid therapy did not stop the progressive course. Therefore an immunosuppressive treatment with methotrexate was begun. After the second intravenous application of this antifolate an amelioration could be noted and after 6 week a normalisation of the visual acuity on the left eye and an improvement from 0.4 to 0.8 on the right eye was obtained. Immunosuppressive treatment was discontinued after a duration of 14 months; now 2 years later, the inital success has been maintained. The advantages of methotrexate in comparison to other immunosuppressive agents are discussed.

Child↗