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Biomedical subjects

W Strobl

Publications and source records attributed to W Strobl.

51 records · Page 3Linked to original sources
PubMed1985

Apolipoproteins and lipoproteins in children with type I diabetes: relation to glycosylated serum protein and HbA1.

Serum levels of cholesterol (C), triglycerides (TG), lipoprotein-C and apolipoproteins (apo) A-I, A-II and B were measured in 30 children with type I diabetes mellitus (16 boys, 14 girls, aged 11-14 years) and in 26 healthy controls (15 boys, 11 girls, aged 10-13 years). For 19 diabetics controls matched for age, sex and relative body weight were selected. The diabetic patients were considered to be in fair metabolic control according to HbA1 levels and glycosylated serum protein concentrations. Mean serum apo A-I, A-II and B, C, TG, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) did not differ significantly between diabetic nondiabetic children. Very low density lipoprotein cholesterol (VLDL-C) was significantly higher in diabetic children than in controls. Serum C and LDL-C levels showed close univariate linear correlations with glycosylated serum protein (LDL-C: r = 0.53, p less than 0.01, C: r = 0.58, p less than 0.01) in diabetics. The ratio LDL/HDL-C was significantly correlated to HbA1 levels (r = 0.47, p less than 0.01). By canonical and multiple linear correlation analysis significant relations of a selected set of variables concerning the control and therapy of diabetes (serum glucose, HbA1, glycosylated serum protein, insulin dose) with a set of lipoprotein variables (C, TG, VLDL-C, HDL-C, LDL-C, apo A-I, A-II, B) could be demonstrated. From these data we conclude that significant relations between atherogenic serum lipids and lipoproteins (C, LDL-C) and the degree of metabolic control exist in diabetic children, even in the absence of marked dyslipoproteinemia.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

[Diagnosis and effective therapy with plasmapheresis in a patient with homozygous familial hypercholesterolemia].

The case of a 17-year-old boy with the homozygous form of familial hypercholesterolaemia is reported. The patient presented tuberous and tendinous xanthomas, arcus lipoides, complete occlusion of the LAD of the coronary arteries, a characteristic family history, and total cholesterol levels greater than 600 mg/dl. Among the available therapeutic regimens we decided to perform plasma exchange treatment, which was introduced by Thompson in 1973 as therapy of this metabolic disorder. After each plasmapheresis, performed so far 7 times, the cholesterol and LDL-cholesterol concentrations dropped to normal levels; they increased again within the next 3 weeks, without, however, reaching the pretreatment levels. Undergoing this treatment, the xanthomas decreased markedly; there are reasons to assume that atherosclerotic lesions might also decrease during this treatment.

Adolescent↗
PubMed1983

Serum apolipoproteins and lipoprotein (a) during the first week of life.

The levels of apolipoproteins, A-I, A-II, B and E, lipoprotein (a) and of total cholesterol and triglycerides were determined in cord serum and in capillary serum at the fifth day of life in a group of 44 term newborns. Additionally, cord serum lipoproteins were estimated. Sera from 26 healthy adults were studied for comparison. The concentrations of lipids and lipoproteins in cord serum were diminished as compared to adult levels. The occurrence of lipoprotein (a) in cord serum in concentrations significantly lower than in adults could be established. Serum apolipoproteins A-I, A-II and B were significantly lower at birth than in the adult, whereas apolipoprotein E levels did not differ from adult concentrations. During the first five days apolipoprotein B levels more than doubled, apolipoprotein A-I increased moderately and apolipoprotein E rose slightly. In contrast, serum lipoprotein (a) and apolipoprotein A-II did not change significantly. Unlike serum cholesterol, the levels of apolipoproteins B and E at day five were significantly correlated to those measured at birth in the same infants. The changes of the apolipoprotein pattern during the first week of life reflect the evolution of the lipid transport system of the newborn and may be related to the increasing utilisation of fat and to hormonal factors.

Adult↗
PubMed1982

[Quantitative-histomorphological study of the abdominal aorta in children and adolescents].

127 abdominal aortas of children and adolescents aged 0-20 years were examined histomorphologically. The quantitative analysis gave the following results: (1) The intimal thickness increases continuously with age. The maximal intimal growth can be observed between the 1st and 3rd and the 12th and 19th year of age, respectively. (2) The media exhibits a similar increase in thickness with a maximal growth between the 1st and 3rd and in the 12th year. (3) The intima-media index rises rapidly from birth until the 3rd year, with a plateau thereafter, and then increases again between the 14th and 18th year. (4) The mean values for these measurements were higher in males than in females in all the age groups except for the 1st year.

Adolescent↗
PubMed1981

[Effect of body weight reduction on platelet function and serum lipoproteins in obese children (author's transl)].

In 11 obese children aged 11,9 +/- 1,3 years total cholesterol (C), triglycerides (TG), HDL-C, LDL-C and apolipoprotein B (Apo B) were estimated in serum after 3 weeks of hypocaloric diet (800 kcal, kJ). In vitro platelet function was evaluated using the tests of ADP-induced aggregation and platelet sensitivity to prostacyclin. The in vivo platelet activity was judged by estimating plasma levels of beta-thromboglobuline (beta-TG) and platelet factor 4 (PF4). A mean weight loss of 5,7 +/- 1,8 kg was observed. Before diet, serum-C, TG and lipoprotein-C concentrations were found to be within the so called "normal range". After three weeks of diet we observed a significant decrease of total-C, which could be accounted for by a decline in the atherogenic LDL-C; furthermore Apo B levels significantly decreased. Concerning the tests of platelet function only for beta-TG and PF 4 a marked decline (to about 50% of the initial values) could be seen. These preliminary results and changes in the lipoprotein are discussed in connection with a possible reduction of the risk for the development of atherosclerotic lesions.

Adolescent↗
PubMed1980

Childhood obesity: serum lipoproteins, glucose and insulin concentrations after an oral glucose load.

In 15 grossly obese children (10 boys, 5 girls, age: 13,1 +/- 2,4 years, mean overweight 71 +/- 13%) an oral glucose load (45 g/m2) was performed. Blood glucose was determined by means of hexokinase method and serum insulin was estimated by radioimmunoassay. According to the criteria of Rosenbloom our results show, that 5 out of the 15 children must be considered to have abnormal glucose tolerance tests. In comparison to reference values basal serum insulin values were slightly elevated, the corespondending concentrations after the oral glucose load were markedly increased in all children. Furthermore, serum lipoprotein determinations were performed using the Lipid-Research-Clinics-Method, NIH, Bethesda: Comparing the mean LDL-cholesterol and HDL-cholesterol concentrations with those of age and sex matched controls no statistical differences could be found. However, the HDL-cholesterol values showed a tendency towards lower concentrations. Our data suggest that disturbances of carbohydrate metabolism in grossly obese children could be only detected after the performance of an oral glucose tolerance test.

Adolescent↗
PubMed1980

Serum lipoproteins in patients with clinical signs of atherosclerosis: peripheral vascular and coronary heart disease.

Lipid and lipoproteins were examined in 7 males patients with coronary heart disease, 10 males with coronary heart and peripheral vascular disease, 25 males with peripheral vascular disease and 10 females with peripheral vascular disease aged between 50-60 years. In general our results demonstrate that in all patients with different locations of atherosclerosis elevated concentrations of total cholesterol, LDL-cholesterol and triglycerides can be found. However low HDL-cholesterol levels measured in all groups should be pointed out. From our data it is concluded that there does not exist a typical lipid or lipoprotein pattern in patients with different locations of atherosclerosis. Only minor differences exist concerning the concentrations of the major lipids and lipoproteins.

Arteriosclerosis↗
PubMed1979

HDL- and LDL-cholesterol in normal weight healthy children 13 years of age.

From 108 healthy 13 years old school children who took part on a longitudinal study in regard to serum lipids and lipoproteins 64 with normal body weight were examined. Lipoproteins were estimated by means of preparative ultracentrifuge and polyanionprecipitation (Heparin and Manganese-chloride) according to the Lipid Research Clinics Methods, NIH, Bethesda. Mean values and S.D. were calculated as: Total cholesterol: 155 +/- 29, 150 +/- 35 mg/dl; LDL-cholesterol 98 +/- 21 and 96 +/- 34 mg/dl; HDL-cholesterol 44 +/- 13 and 44 +/- 13 mg/dl for males and females respectively. The few data from the literature showing wide variations in LDL- and HDL-cholesterol concentrations are compared with our results; methodological considerations indicate that for further epidemiological studies concerning the possible risk factors for premature atherosclerosis standaradized laboratory tests should be provided.

Adolescent↗
PubMedDate not supplied

[Single event multilevel surgery to improve gait in diplegic cerebral palsy - a prospective controlled trial].

AIM: To evaluate prospectively the outcome of gait-improvement surgery in children with spastic diplegia. METHOD: Three-dimensional gait analysis was performed in twenty children with spastic diplegia. Ten children underwent single event multilevel surgery for gait improvement. Indications for individual procedures followed a fixed set of selection criteria. The other ten children continued with their physiotherapy programme and served as a control group. A second gait analysis was performed in all children after 1.5 years. Time-distance parameters and kinematics of the pelvis, hip, knee and ankle joints in the sagittal plane served as main outcome measures RESULTS: The patients walked faster with an increased stride length after surgery in comparison to the conservatively treated controls. The average pelvic tilt increased slightly and the range of motion of the knee joint increased considerably after multilevel surgery. The motion at the ankle remained unchanged over the study period in both the groups. An improved knee extension during the stance phase of gait served to improve stance limb stability and facilitated an unhindered swing phase of the opposite limb. CONCLUSION: This prospective trial showed favourable changes in gait function after multilevel surgery in spastic diplegic children.

Child↗
PubMedDate not supplied

[Treatment of a radial club hand].

The present study includes a total of 12 patients who had a longitudinal radial deficiency which produced a club hand. 17 hands were affected. Complete radius aplasia (type C) was most frequent, followed by partial radius aplasia (type D) and radius hypoplasia (type E). 7 patients (8 hands) were treated surgically by centralisation of the ulna. Average age at surgery was 46 months. Indications for surgery were followed according to Blauth. The results were evaluated using the criteria of Hippe and Blauth. All patients were pleased with the results, and in each case there was no doubt that function and appearance could be improved. The results of this study demonstrate that correction of radial clubhand by centralisation of the ulna produces a good functional result if the criteria of Blauth are followed: functional mobility of the elbow joint of more then 90 degrees, and the possibility of passive correction of the deformity preoperatively.

Child, Preschool↗