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Biomedical subjects

W T Boone

Publications and source records attributed to W T Boone.

11 recordsLinked to original sources
PubMed1999

Cardiovascular and metabolic responses during 30 minutes of treadmill exercise shortly after consuming a small, high-carbohydrate meal.

Fourteen male endurance runners (VO2peak = 64.8 +/- 8.7 ml x kg(-1) x min(-1)) participated in this study to determine the cardiovascular and metabolic responses during 30 minutes of treadmill running at a moderate intensity soon after consuming a small, high-carbohydrate meal (CHO-M). In randomized order on separate days, subjects either consumed the CHO-M (2088 kJ; 77% carbohydrate) 15 minutes prior to running or they fasted (FAST). Data were collected for 5 minutes beginning at 5, 15, and 25 minutes of the 30-minute run. Heart rate (HR) was determined, a metabolic measurement cart was used to determine VO2 and respiratory exchange ratio (RER), and the CO2 rebreathing procedure (Collier plateau method) was used to determine cardiac output (Q). Statistical analyses indicated that the CHO-M did not affect HR, stroke volume, Q, VO2, or RER compared to FAST. However, all grouped CHO-M and FAST variables, except VO2, changed significantly across the 30-minute exercise session. These data suggest that a small, high-carbohydrate meal does not alter cardiovascular and metabolic function during moderate-intensity exercise in endurance-trained subjects.

Adult↗
PubMed1998

Screening colorectal cancer--rational guidelines.

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer deaths in The United States. It affects men and women equally and increases with the age of the population. The adenoma-adenocarcinoma sequence presents a unique opportunity for interdiction in the progression to colorectal cancer. Our screening and surveillance recommendations are cost effective and reduce the incidence and mortality of colorectal cancer. Most of our progress in the last decade has come from the screening and surveillance of high risk categories of patients for colorectal cancer. If progress is to continue, we must carry our message to the general population with average risk factors which constitutes 75% of colorectal cancer.

Colorectal Neoplasms↗
PubMed1998

Colorectal cancer--chemoprevention.

Colorectal cancer is the second leading cause of death from cancer in The United States. During the last fifteen years, emphasis has been placed on identification of high risk patients and families and outline of appropriate surveillance regimens for normal and high risk patients for colorectal cancer. Parallel to this effort, abundant clinical data has been accumulated that chemoprevention of colorectal cancer with nonsteroidals and aspirin may be possible. Interruption of prostaglandin metabolism appears to be one of the mechanisms of action but not the only therapeutic arm. Currently, sulindac, aspirin, calcium and selenium supplementation are attractive recommendations to at risk patients awaiting results of clinical trials. Other agents in development add excitement to the concept of colorectal cancer chemoprevention.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1995

Influence of a 36-h fast on the central and peripheral components of VO2 during submaximal exercise and peak oxygen uptake.

To determine if a 36-h fast affects the central and peripheral components of VO2 during submaximal exercise and peak oxygen uptake (VO2 peak), 10 physically healthy males exercised first for 10 min at approximately 60% of their VO2 peak and then to fatigue. Their cardiovascular responses were compared with those of 10 physically healthy controls (males) who were individually matched by VO2 peak values. Fasting had no significant effect on the central (heart rate, HR; stroke volume, SV; cardiac output, Q) and peripheral (arteriovenous oxygen content difference, a-vO2 diff.) components of VO2 during submaximal exercise. The respiratory exchange ratio (RER) during submaximal exercise was significantly decreased in the fasted subjects. Based on the RER, fasting altered substrate utilization of the muscle and thereby increased the contribution of fat during submaximal exercise. Fasting had no significant effect on VO2 peak, HR or O2 pulse, but RER was significantly lower during incremental exercise to fatigue. These results demonstrate that VO2 during submaximal exercise in fasted subjects is achieved by similar central and peripheral responses as found in non-fasted subjects, and that fasting does not reduce VO2 peak.

Adult↗
PubMed1978

Colonic basophil hypersensitivity.

Contact hypersensitivity reactions were elicited by intraluminal application of DNCB to the colon of guinea pigs and were found sometimes to contain large infiltrates of basophils. These colonic basophil hypersensitivity reactions were accompanied by systemic sensitization and were not seen in nonspecific colonic inflammatory responses induced by croton oil. The heterogenous immune inflammatory responses induced in the colon by DNCB contact sensitivity may serve as a model for the study of inflammatory bowel disease.

Animals↗
PubMed1969

Histoplasmosis.

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Amphotericin B↗