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Biomedical subjects

W T Dungan

Publications and source records attributed to W T Dungan.

At least 19 recordsLinked to original sources
PubMed2000

Late onset of accessory pathway conduction in a patient with complete AV block.

This case report discusses a patient with complete AV block in early childhood. The patient required a permanent pacemaker. At 6 years of age, intermittent preexcited beats were noted on telephonic transmissions. At 7 years of age, 1:1 preexcitation was noted in sinus rhythm. Therefore, late onset of antegrade accessory pathway function is demonstrated. This case provides evidence of developmental changes in accessory pathways. This may explain age related differences in the onset of narrow complex tachycardia in the school age years.

Age of Onset↗
PubMed1985

Permanent pacing through a persistent left superior vena cava: an approach and report of dual-chambered lead placement.

The patient with a persistent left superior vena cava who requires permanent pacing presents difficulties if no right superior vena cava is present or if it is encountered unexpectedly at pacemaker implantation. A case is presented that illustrates potential problems and suggests a general approach to this situation. Successful transvenous universal pacemaker insertion through a persistent left superior vena cava is reported.

Adult↗
PubMed1982

Lipid storage myopathy in infantile Pompe's disease.

An infant died at 8 months of age with a history of developmental regression, hypotonia, severe weakness, cardiomegaly, congestive heart failure, and hepatomegaly. A diagnosis of Pompe's disease (glycogenosis type II) was established by muscle biopsy at 5 months of age. Vacuolar myopathy involved muscle fibers of histochemical type I more than type II. Many vacuoles were filled with glycogen. In addition, increased amounts of neutral lipid were demonstrated by oil red O stain, electron microscopy, and quantitative analysis. Acid alpha-1,4-glucosidase activity was demonstrated to be deficient. Biochemical studies failed to determine the cause of the lipid accumulation, but demonstrated a low total concentration of carnitine in the muscle (6.37 nmole/mg of protein), associated with elevated activities of carnitine palmityl-transferase and palmityl-coenzyme A dehydrogenase. Palmityl-coenzyme A synthetase activity was in the normal range.

Carnitine O-Palmitoyltransferase↗
PubMed1981

Arrhythmogenic right ventricular dysplasia: a cause of ventricular tachycardia in children with apparently normal hearts.

Arrhythmogenic right ventricular dysplasia (ARVD), a cardiomyopathy with hypokinetic ares limited to the wall of the right ventricle (RV), has been recently described as a cause of recurrent ventricular tachycardia (VT) in young adults with an otherwise normal heart. We reviewed 26 cases of recurrent VT in children and found 10 patients with no clinically recognizable abnormality aside from the dysrhythmia. Three of these 10 patients had ARVD. These three patients were initially seen at 1, 12, and 14 years of age with premature ventricular contractions (PVCs) and/or VT. Sustained VT occurred spontaneously or during stress testing. The PVCs and the VT were of left bundle branch block contour, suggesting RV site of origin. The diagnosis of ARVD was based on wall motion abnormalities of the RV demonstrated angiographically. We suggest that ARVD could be a significantly common cause of VT in children with an apparently normal heart.

Adolescent↗
PubMed1980

Indomethacin treatment in patent ductus arteriosus. A double-blind study utilizing indomethacin plasma levels.

23 premature infants were placed on a randomized double-blind study to evaluate the effectiveness of indomethacin in closing a patent ductus arteriosus. Infants received 0.2 mg/kg indomethacin or placebo by gavage. In the treatment group, 7 patients responded out of a total of 12, while in the placebo group, 2 responded out of a total of 11. Indomethacin plasma levels were obtained in 6 patients in the treatment group. Plasma levels showed marked variability in peak level (60-3,100 ng/ml), time to peak level (0.5-6 h) and t1/2 (1 to greater than 24 h).

Clinical Trials as Topic↗
PubMed1979

Problems in counseling the epileptic mother.

Epileptics, medical colleagues, and the public must be educated regarding the teratogenicity of anticonvulsants to the developing fetus. To prevent the serious problems of the fetal hydantoin-barbiturate syndrome, epileptic mothers must be given counseling. There are numerous problems encountered in counseling any individual with genetic disorders and dull intellect. More than the usual time and effort and cooperation of many agencies is needed to achieve success in counseling.

Abnormalities, Drug-Induced↗