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Biomedical subjects

W T Friedewald

Publications and source records attributed to W T Friedewald.

29 records · Page 2Linked to original sources
PubMedDate not supplied

A double blind study of the effects of zinc sulfate on taste and smell dysfunction.

A randomized, double blind crossover study of the effects of zinc sulfate and placebo was carried out in 106 patients with taste and smell dysfunction secondary to a variety of etiological factors. In the patient group prior to treatment, mean serum zinc concentration and leukocyte alkaline phosphatase activity were significantly lower than normal. Results indicate that zinc sulfate was effectively equivalent to placebo in the treatment of these disorders. Although these results demonstrate abnormalities of zinc metabolism in some patients with taste and smell dysfunction they fail to provide evidence for a single, therapeutic approach to the many disorders which are associated with abnormalities of taste and smell. However, the methods and procedures developed in this study demonstrate that taste and smell dysfunction can be studied in a quantitative, systematic manner.

Adult↗
PubMedDate not supplied

Planning and implementation of large clinical trials.

The large-scale collaborative clinical trial has become an important activity in the biomedical research spectrum. It is the clinical trial that determines most precisely the efficacy of treatment of preventive regimens. These large studies, which usually cost tens of millions of dollars and use large numbers of research facilities, have a major impact on research and medical practice. Consequently, it is required that a number of factors be carefully assessed before any such study is undertaken. A formalized decision process has been developed by the National Heart, Lung and Blood Institute to aid in the formulation, design, conduct, analysis and dissemination of the results of clinical trials. This decision process, which provides a planning framework for the trial, is described here. The framework is constructed around three major decision points at which resources are committed: to plan the trial, to conduct the trial, and to terminate and disseminate the results of the trial.

Clinical Trials as Topic↗
PubMedDate not supplied

Decline of coronary heart disease mortality in the United States.

Annual mortality rates for cardiovascular disease in the U.S. have declined steadily since at least 1968, with an accelerated rate of decline since approximately 1972. Although these trends have been seen in both men and women and in both Blacks and Whites, there have been relative differences in the rate of decline by region and state within the U.S. The relative importance of improved prevention vs. treatment in accounting for this decline has been discussed at length but not resolved, and efforts to gather relevant data are still being undertaken. Nonetheless, important changes have occurred in dietary habits with, for example, lower animal and higher vegetable fat consumption; in cigarette smoking rates, with especially important declines in middle-aged men; and in high blood pressure control, with improved levels in both genders and especially in Blacks, who have the highest rates.

Adult↗