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Biomedical subjects

W T Hall

Publications and source records attributed to W T Hall.

At least 19 recordsLinked to original sources
PubMed1987

Cycad (zamia) poisoning in Australia.

The Cycads belong to an ancient family of plants and were the cause of the first well documented plant poisoning in Australia when Captain Cook's men and their pigs were affected by eating them. Subsequent reports particularly by early explorers refer to toxicity of the seeds to man. One reason for this was the evidence that the natives ate them. Subsequent reports and experimental work established the toxicity to sheep and cattle. In sheep and cattle 2 syndromes occur, ataxia and liver damage. In cattle the former is the better known, the spinal cord lesion being mainly a demyelination of the sensory pathways. The liver damage is necrosis and fibrosis.

Animals↗
PubMed1980

Immunoglobulin classes in serum antibody reactions in cattle following vaccination with Brucella abortus strain 19 and killed 45/20 vaccines.

A group of 4 cows was vaccinated with Brucella abortus strain 19, followed 8 weeks later by a single dose of B. abortus 45/20 vaccine. A similar group received 2 doses of B. abortus 45/20 vaccine 8 weeks apart. The antibody responses of the groups were compared by testing whole serums and separated IgM and IgG fractions by the Rose Bengal Plate (RBP) agglutination and the complement fixation tests (CFT) using rough and smooth B. abortus antigens. Animals that had received B. abortus strain 19 responded to the 45/20 vaccine with increased titres to the smooth antigen. These relevant antibodies were predominantly of the IgG class. Standard CFT and RBP test antibodies could be detected in IgM and IgG fractions after the primary inoculation with B. abortus strain 19 vaccine.

Animals↗
PubMed1979

Chemotherapy of acute bovine anaplasmosis.

The efficacy of a standard tetracycline, imidocarb and a new experimental long-acting tetracycline (T-200) in the treatment of anaplasmosis was examined in 5 groups of 9 nonsplenectomised, adult, 4-year-old, speyed cattle. The efficacy of T-200 was further examined using 9 splenectomised calves. One treatment of imidocarb (3.5 mg/kg) or T-200 (20 mg/kg) or 2 treatments (10 mg/kg) of a standard tetracycline were very effective in controlling the infection in the intact cattle. On inoculation of T-200 (20 mg/kg) controlled infection in 5 splenectomized calves, whereas all 4 untreated control calves died. T-200 did not sterilise either intact or splenectomised cattle.

Acute Disease↗
PubMed1979

Providing health and social services to illegal alien families: a dilemma for community agencies.

Proposals for dealing with illegeal migration from Mexico to the United States generally do not recognize it as an international social problem. The proposals also present contradictory solutions. Amnesty, a humanitarian policy, is being suggested as well as increased restrictions and punishments, a policing policy. However, in the absence of a comprehensive national policy, community social and health care programs must provide services to illegal aliens. This article attempts to document some of the issues that illegal immigration presents for community agencies.

Child Health Services↗
PubMed1977

Consultation as a political process.

Consultation may be viewed as a political-bargaining process in which actors seek to maximize at minimal cost expertise, organizational position, and organizational reputation. A view of consultation as political process allows for a shift in language in discussions of consultation. Such a language shift suggests shifts in the social meaning of the consulation process. Emphasis was placed on four suggested functions of consultation: definition and legitimation of a situation or of facts as "problematic"; raising the priority of an i5sue on the agenda of action in a consultee's agency; legitimation of deviant administrative behavior, and creation and sustenance of interagency linkages. A perspective is proposed that looks at the consequences as well as the intents of the process. This view of consultation can be studied emprically.

Humans↗
PubMed1977

Experience with Devine-Horton dermal patch graft for Peyronie's disease.

Peyronie's disease is a malady frequently seen by the urologist. Many conservative treatment modalities have yeilded successful alleviation of symptoms in a significant number of these patients. A number, however, do not respond and are left with penile curvature and pain on erection such that intercourse is severely impaired. Devine and Horton have proposed resection of the plaque with replacement of the defect with a full-thickness dermal graft. They reported excellent results with minimal complications. Five patients were treated by this technique with successful penile straightening and alleviation of pain. To date, follow-up results have been gratifying, and the Devine-Horton dermal graft technique is suggested for use in treatment of patients with disabling Peyronie's disease.

Aged↗
PubMed1977

Protective effect of immune serum globulin (ISG) against hepatitis A infection in a natural epidemic.

Serologic evidence now confirms epidemiologic evidence that human immune serum globulin (ISG) protects susceptible patients from hepatitis A provided it is administered prior to exposure to the virus. In two wards of young patients housed at the Lynchburg (Virginia) Training School and Hospital for the mentally retarded, 44 out of 60 patients had no detectable antibody to hepatitis A prior to an epidemic which took place there in 1970; 12 of 19 non-immunized susceptible patients contracted the disease, while only four of 25 patients receiving ISG developed hepatitis. These four were probably infected with the virus prior to ISG administration. Of the 16 patients with pre-existing antibody, none showed any signs of symptoms of hepatitis.

Antibodies, Viral↗
PubMed1977

Distribution of antibody to hepatitis A antigen in a population of commerical plasma doners.

Plasma samples from 245 regular plasma donors for Plasma Alliance, Inc. (Knoxville, Tenn.) were tested for the presence of antibody to hepatitis A antigen. Antibody was detected at an immune adherence hemagglutination titer of 1:10 or greater in 37% (91 of 245) of the donors. A statistically significant difference in the frequency of anti-hepatitis A was found between the 18- to 29-year-old group (30%) and the 30- to 49-year-old group (57%). No significant differences between whites and blacks or males afemales were observed. Eighty percent of the donors were in the age range of 18 to 29 years, whereas 48% of the higher-titered plasmas (1:1,000 or greater) were in the 30 to 49 age group. By preselection of donors, it would be possible to produce an immune serum globulin with a specific anti-hepatitis A titer.

Adolescent↗
PubMed1976

Purification and some properties of the phosphoprotein from rat incisors.

The phosphoprotein of rat incisors has been purified by successive gel and ion-exchange chromatography. The product gave a single band on polyacrylamide gel electrophoresis and contained approximately 34% phosphoserine and 32% aspartic acid. Alkaline elimination experiments showed all the phosphate to be present as phosphoserine. Ultraviolet spectra in the presence or absence of ATP showed that the phosphoprotein did not contain an nucleotide moiety as suggested by Veis, A., Spector, A. R. and Zamoscianyk, H. ((1972) Biochim. Biophys. Acta 257, 404-413) for bovine dentin phosphoprotein.

Amino Acids↗
PubMed1976

Typical type-C virus in human leukemia.

The virus HL-23, recently isolated from a patient with myelogenous leukemia, was compared by electron microscopy with virus-like particles observed in human tissues and with several mammalian type-C virus particles. It closely resembled the typical type-C virus particles of murine, feline, and nonhuman primate species, and differed from all particles previously reported in human tissues, including the atypical human placental particle.

Animals↗
PubMed1976

Ruthenium red-staining coat of paired neoplastic and nonneoplastic mouse cell lines in cluture.

The ruthenium red-staining coat (RRSC) of a pair of neoplastic and nonneoplastic cell lines derived from a common pool of mouse embryo cells was examined by electron microscopy. The object was to establish whether a thickening of RRSC is associated with "spontaneous" neoplastic transformation of cells in culture. Ruthenium red has an affinity for acid mucopolysaccharides of the cell coat. Differences in thickness of RRSC between cells of these neoplastic and nonneoplastic lines were negligible.

Animals↗
PubMed1976

Dermal ulceration of mullet (Mugil cephalus).

Phycomycotic granulomas are described in the skin of 7 mullet (Mugil cephalus) from extensive outbreaks of dermal ulceration in fish in south-east Queensland. The fungus involved was probably a member of the Family Saprolegniaceae, but was not cultured from the lesions. A myxosporidian infection was present in some fish. The primary cause of the disease is uncertain.

Animals↗
PubMed1976

Infection and serological responses in cattle given 45/20 vaccine and later challenged with Brucella abortus.

One of 2 groups of 15 non-pregnant cows was vaccinated twice 6 weeks apart by the subcutaneous route with a killed adjuvant 45/20 vaccine. At the time of the first vaccination a bull was introduced for a period of 14 weeks. All animals were challenged with 1.5 x 10(7) Brucella abortus organisms given into the conjunctival sac 18 weeks after the second vaccination of the vaccinated group. The largest lesions at the site of vaccination (8 cm diam.) were seen 2 weeks after inoculation. Small lesions were still visible in 8 animals 1 year after vaccination. There was no appreciable serological response to the first vaccination. After the second vaccination some animals gave low positive titres, but all were serologically negative after 10 weeks. After challenge the highest complement fixation and standard agglutination tests were given by animals in the non-vaccinated group. Serum samples from 5 animals (2 vaccinated and 3 not vaccinated) showed a prozone effect at low dilution in the complement fixation test. In the non-vaccinated group 9 of the 15 cows became pregnant, 7 of which had weak calves or aborted and were shown to be infected with Br. abortus. The other 2, of which 1 was serologically positive, reared normal calves. Of the 10 vaccinated cows that became pregnant, 8 reared calves, 1 had a weak calf and the other aborted. These 2 cows and 1 other were infected. Considering the 11 infected pregnant animals 9 or 80 percent, lost their calves. The number of surviving calves was significantly higher in the vaccinated group indicating that the use of this 45/20 vaccine has considerable economic benefit. In each group 3 of the non-pregnant animals were infected.

Agglutination Tests↗
PubMed1976

Social science, social work and pharmacy.

In an effort to make pharmacy a more patient oriented health profession, pharmacy students at the University of Pittsburgh are required to take a course entitled, Social Sciences in Pharmacy. Besides drawing from the diverse social and behavioral sciences this course also includes material from the field of social work. This article describes the course and the students' reactions to it. It also provides an overview of some of the recent trends in the field and suggests areas where consultation between pharmacist and social worker may be indicated.

Curriculum↗
PubMed1975

Growth and differentiation in culture of leukemic leukocytes from a patient with acute myelogenous leukemia and re-identification of type-C virus.

Conditioned medium from a culture of whole human embryo cells stimulated prolonged exponential growth in suspension culture of leukocytes from a patient with acute myelogenous leukemia. Ten to 20% of the cultured cells consistently differentiated into mature granulocytes including neutrophils, eosinophils, and basophils. The proportion of lymphocytes declined after culturing, and tests for Epstein-Barr virus antigens were negative. An abnormality of a G group chromosome was observed in some metaphases from the patient's fresh bone marrow and from the cultured leukocytes, indicating growth in vitro of leukemic cells. After 4-10 weeks in culture, a budding type-C virus was continuously released by the cultured leukocytes, predominantly by undifferentiated blast cells. This virus was originally identified in three different cultures of a peripheral blood specimen obtained at the time of diagnosis. Subsequently, this virus was identified by reverse transcriptase (RNA-dependent DNA polymerase) assays and by electron microscopy in cultured leukocytes from a bone marrow specimen obtained 14 months later from the same patient. Virus produced by cultures of both specimens was closely related, if not identical, to the woolly monkey type-C virus.

Cell Differentiation↗