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Biomedical subjects

W T Hubbert

Publications and source records attributed to W T Hubbert.

At least 19 recordsLinked to original sources

A descriptive study of dairy goat predation in Louisiana.

Questionnaires concerning herd size, housing and management, and previous instances of predation were mailed to 124 goat owners in Louisiana. Postcards were mailed over a period of one year on a monthly basis, to the 84 individuals who responded to this questionnaire. Owners were asked to indicate whether they had seen predators on their property and whether any goats were injured or killed by the predators. Upon receipt of any postcard with a "yes" answer to either of these questions, a telephone interview was conducted to determine the exact circumstances of predator experience. The interview format included time, physical circumstances, and detailed questions about the actions of the predator and the goats. In 85% of the cases, the predators sighted were reported as dogs, and most of these were thought to be pets, rather than wild. Instances of attacks occurred most frequently during periods of reduced light. No clear seasonal pattern of attacks emerged. Four management factors were associated with a reduction in number of attacks; penning the goats at night, use of a night light, proximity of the herd to an occupied residence, and presence of a dog.

Animal Husbandry

A questionnaire for the clinical assessment of veterinary adverse drug reactions.

Despite widespread occurrence of adverse drug reactions (ADRs), their clinical identification has been a nonreproductible act of unspecified subjective judgment. Adequate criteria have not been available for diagnostic decisions about the cause of an observed clinical manifestation. To improve scientific precision in diagnosis of ADRs, the ADR questionnaire has been developed to rank the probability of linking a drug to a suspected clinical manifestation. The questionnaire provides a scoring system for six axes of decision strategy: previous general experience with the drug, alternative etiologic candidates, timing of events, drug levels and evidence of overdose, dechallenges and rechallenges. The sum of the scores is partitioned to rate the candidate ADR as definite, probable, or unlikely.

Animals

Reporting of zoonotic diseases.

Departments of public health and agriculture in all 50 states of the United States and the District of Columbia were queried in 1977 to determine which of some selected zoonoses are reportable, the method of reporting and the diagnostic stage at which reporting is required. Fifty-three of the 62 diseases on the public health questionnaire were listed as reportable, with hepatitis A required by 49 of the 51 jurisdictions. Telephone reporting was required in nearly 19% of the disease-jurisdiction combinations and, in nearly 55%, reporting was required when the disease first was suspected. Thirty-three of the 41 diseases on the agriculture questionnaire were reportable, with anthrax most frequent. Telephone reporting was required in 30% of the reportable situations and suspected diagnoses were reportable in 54%. The disease lists varied markedly between the public health and agriculture agencies.

Agriculture

Experimental toxoplasmosis in calves and pregnant cows.

Experimental Toxoplasma gondii infections were studied in pregnant cows and in calves. In tests to compare their virulence, three strains of the toxoplasmal parasite were red to cats; then fecal oocysts were collected and given per os to calves. In tests to determine their effects, virulent tachyzoites or oocysts were given to 10 calves and to 22 pregnant cows by the oral, IV, or intraamniotic routes. Clinical signs were fever and inappetence. One cow in early gestation aborted 24 days after IV administration of tachyzoites. Gross and microscopic changes were slight and nonspecific. Toxoplasmas were isolaated from brain or liver of 4 cows, placenta of 2 cows, gastric contents of 2 near-term fetuses, and blood and tissues of calves. Toxoplasmas were not isolated from control cows.

Abortion, Veterinary

Interfacing professional training in health maintenance and preventive medicine.

Because of emerging economic realities of the latter half of this century, the practice of preventive medicine, as opposed to curative medicine, is becoming essential in developed and developing countries. This holds true in veterinary medicine as well as in human medicine, and as we become increasingly aware of this fact, we also recognize the increasing interdependence of both fields. To determine the extent to which veterinarians are prepared to deal with this change in emphasis, two surveys have been prepared; one directed to various specialty groups within the profession and the other directed to schools of veterinary medicine. The first survey was designed to identify areas in which veterinarians felt their training had been deficient relative to decision making in applied preventive medicine. The second survey queried the schools to determine what changes had been made in their curricula to remedy these inadequacies.

Curriculum

The need for integrated control programs for zoonoses affecting livestock.

Prior to recognition of etiologic agents of zoonoses (infections transmitted between animals and man), physicians encountered these illnesses in man and veterinarians observed them in animals. As the agents were identified, interspecies relationships (and spread) became evident and control programs evolved without consideration of cost-effectiveness. Today, the public demands efficient use of financial resources. Human health as well as economic losses are concerns of animal health agencies. Zoonoses affecting livestock, though not major priorities among public health agencies, cannot be ignored. It seems economical, therefore, to combine the efforts of these agencies in zoonoses control. This would benefit human health by reducing the animal reservoirs and the livestock industry will benefit by lowered production costs.

Animals

Occupational health and safety programs in schools of veterinary medicine.

From a survey of 22 U.S. veterinary schools and the university campuses where they are located, it was found that none of the schools had a full- or part-time health and safety officer whereas 16 campuses did. On 18 campuses some form of safety committee existed whereas such committees had been formed in only 12 schools. There was no relationship between the level of school or campus safety organization and presence (10 schools) or absence (12 schools) of an OSHA approved state occupational safety and health plan. An occupational health "bookshelf" reference list is appended.

Evaluation Studies as Topic

Development of a health and safety program at the Louisiana State University School of Veterinary Medicine.

An accident prevention and zoonotic disease control program at the School of Veterinary Medicine, Louisiana State University, was developed by a Health and Safety Committee comprised of members from all instructional departments. The program incorporated safety educational input during the basic, preclinical, and clinical years; a standardized accident reporting procedure; rabies vaccination, with serologic evaluation; a blood serum bank; and recommendations for future control procedures.

Accident Prevention

Immunoglobulin concentrations and bovine enterovirus inhibitors in fetal bovine fluids.

Fluids from 53 bovine fetuses ranging in age from 90 to 240 days were examined for immunoglobulin G (IgG) and immunoglobulin M (IgM) and neutralizing activity to ten bovine viruses. Non-specific inhibitors to bovine enteroviruses were found in serum, allantoic, and amniotic fluids of most samples tested. In most cases, serum IgG were within normal values. Neither IgG nor IgM was detected in amniotic fluids, whereas 2 samples of allantoic fluid contained traces of IgG.

Allantois

Changes of biochemical constituents in bovine fetal fluids with gestational age.

Serum, amniotic fluid, allantoic fluid, stomach contents, and urine were taken from 141 bovine fetuses 120 to 245 days old. The concentrations of the biochemical constituents were examined in tests to ascertain systematic changes with increasing crown-rump length, i.e., gestational age. As the crown-rump length increased, glucose concentrations decreased in allantoic fluid, amniotic fluid, and stomach contents; creatinine and uric acid concentrations increased in serum, allantoic fluid, and stomach contents; thyroxine concentrations increased in serum and allantoic fluid; potassium decreased in amniotic fluid and stomach contents; and total iron-binding capacity increased in amniotic fluid. The data in the present report can be used to identify the fetal fluid obtained by amniocentesis, to estimate the age of the fetus, and to aid the diagnosis of nutritional or infective processes that might affect the fetus.

Allantois

Developmental changes of tissue enzyme patterns in the bovine fetus with gestational age.

The activities of aspartate aminotransferase (GOT), alanine aminotransferase (GPT), alkaline phosphatase (alkP), creatine kinase (CPK), and ornithine carbamoyltransferase (OCT) were determined in liver, heart, skeletal muscle, brain, kidney, lung, spleen, adrenals, pancreas, thyroid, thymus, and red cells of 56 bovine fetuses varying in gestational age from 115 to 255 days. The tissue aminotransferase activities were the most variable with gestational age. The GPT activity of liver, kidney, spleen, and red cells and the GOT activity of red cells decreased with fetal age. The GPT activity of heart, brain, and skeletal muscle and the GOT activity of adrenal, brain, and skeletal muscle increased with fetal age. Increasing activities were also described for adrenal and brain alkP and for brain and skeletal muscle CPK. In contrast, the OCT activities were fairly constant for each tissue as a function of gestational age.

Alanine Transaminase

Adult isoantigen and lectin reactivity of bovine fetal red cells.

Evidence is presented that fetal red cell membranes differ from membranes of their dams in isoantigenic and lectin reactivities. Evidence for nonsimultaneous development of 'adult' antigenic factors is extended. It is proposed that 'adult' phenogroups develop from replacement or displacement of factors in 'fetal' phenogroups.

Animals