Biomedical subjects

W T Thanassi

Publications and source records attributed to W T Thanassi.

4 recordsLinked to original sources

PubMed2000

The Lyme disease vaccine: conception, development, and implementation.

In the past 20 years, remarkable strides have been made toward understanding and preventing Lyme disease in humans. In December 1998, the U.S. Food and Drug Administration approved a recombinant outer surface protein A vaccine against Lyme disease (LYMErix, SmithKline Beecham, Philadelphia, Pennsylvania). The vaccine, which is derived from a lipidated outer surface protein of the causative spirochete Borrelia burgdorferi, is important because it may decrease the morbidity and financial costs associated with Lyme disease. Its mechanism is unique because it works inside the tick vector itself, preventing the human from becoming infected.

Animals↗

PubMed1999

Successful vaccination for Lyme disease: a novel mechanism.

Two vaccines are on the horizon for the prevention of Lyme disease, the most common vector-borne illness in the US and Europe. This review describes the pathogenesis and clinical illness of Lyme disease, as well as the sequence of events that led to the development of these novel vaccines. The results of the most recent Phase III human trials are reported.

Journal Article↗

PubMed1998

Immunizations for international travelers.

Each year more than 45 million Americans travel abroad for work or pleasure, and over 20 million of these travel to rural areas or developing countries. While the major medical risks of international travel are often exaggerated, the incidence of minor illness is not. Persons going to Asia, Africa, or Latin America for one month run a 65% to 75% chance of becoming ill, although only 1% will require hospitalization. The two most common illnesses that affect travelers, which do have immunizations and are often overlooked by physicians, are influenza and hepatitis A. The risk of illness to the traveler varies by health and age status, by the region to be visited, by the time of year, and by the length of the journey. Immunization advice for the traveler, therefore, is complicated and is best approached in a systematic manner. This article outlines six steps to sound immunization advice. These steps include ascertaining the traveler's special individual needs, routine immunization status, and routine travel immunization status, as well as the entry requirements for the country to be visited, geographically indicated vaccines, and immunizations as indicated for extended stays abroad.

Adult↗

PubMed1997

Immunizations and travel.

Determining the appropriate immunizations for international travelers is a complex, multifaceted process. This article proposes a stepwise and systematic approach to the immunization needs of the traveler-patient. Vaccines for routine health maintenance as well as special issues of the elderly, pregnant, immunocompromised, and child are important in the initial evaluation. Specific travel immunizations (i.e., those for routine travel, those required by a country, those that are geographically indicated and immunizations for extended stays) comprise the remainder of the immunization interview. Health care providers should also be familiar with cost and risk statistics, both the risk of the traveler contracting an illness overseas and the risk of side effects from the vaccines themselves. With such cost-benefit analysis, the provider can offer the traveler immunizations as well as information.

Adolescent↗