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Biomedical subjects

W T Ulmer

Publications and source records attributed to W T Ulmer.

At least 19 recordsLinked to original sources
PubMed1992

[Obstructive respiratory tract diseases--new standards in therapy].

AIMS: Presentation of modern-day therapeutic procedures in various stages of obstructive airway diseases. MAIN TOPICS: Subacute bronchitis and hypersensitivity of the bronchial system are early symptoms of obstructive diseases of the airways. Highly effective prophylactic treatment includes adrenocortical hormones (ACH) (corticosteroid) inhalation and antibiotics used individually or in combination for a variety of indications, are now available. In cases of manifest airway obstruction (Stage B), bronchodilators are additionally required. Of those presently available, the beta 2 sympathicomimetics head the list. For anticholinergics and theophylline there are additional indications. If the resulting response is unsatisfactory, oral ACH must be employed in addition to ACH inhalation and bronchodilators. Cromoglycate administered for a period of four to six weeks should always be tried. In the stage of severe exacerbation (C), intravenous water-soluble ACH in combination with antibiotics, are necessary. The entire spectrum of bronchodilators should also be utilized. Functional analysis during treatment prevents under- or overtreatment. CONCLUSIONS: In particular in the early stages, the aim of treatment of obstructive airway diseases is prophylactic.

Administration, Inhalation↗
PubMed1991

[Cough].

Explore the source record for details and available documents.

Bronchitis↗
PubMed1990

Western blot analysis of water-soluble wheat flour (Triticum vulgaris) allergens.

Water-soluble wheat flour allergens were analyzed using the western blot technique. The sera of 130 bakers (42 with wheat flour allergy, 88 without allergy) were analyzed for IgE, IgG, and IgG4 binding towards wheat flour allergens. Three major allergens with molecular weights of 47, 17, and 15 kD were identified (Tri v Bd 47, Tri v Bd 17, and Tri v Bd 15; IUIS allergen nomenclature) by their ability to bind IgE from approximately 50% of the allergic sera. The specificity of the IgG was mostly directed against three high molecular weight components (134, 122, and 98 kD). In contrast, IgE and IgG4 was found frequently against the major allergens. 40% of healthy donors versus 12% of the asthmatic bakers had no detectable IgG4 against wheat flour extract. The biological activity of the water-soluble wheat flour components has been shown by their ability to induce histamine release from basophil leukocytes obtained from patients with bakers' asthma. The release of histamine from basophil leukocytes significantly correlated with the presence of IgE antibodies against wheat flour components of 47, 17 and 15 kD. A regulatory role of wheat flour specific IgG4 in allergic diseases could not be evaluated by western blot analysis.

Antibodies, Monoclonal↗
PubMed1979

[Treatment of obstructive disease with fenoterol-ipratropiumbromid dosage aerosol (IK 6). Short and long-terms results (author's transl)].

Fenoterol-Ipratropiumbromid dosage aerosol (IK 6) showed in acute experiments on patients with chronic obstructive disease optimal bronchodilatation. In this mixture of Fenoterol and Ipratropiumbromid only 50% of the optimal dosage of the beta 2-stimulator is present. This minimizes the side-effects and increases the therapeutic range. Still the bronchodilatation is optimal. 92 patients were treated with this mixture for between 1 and 160 months. No side-effects were seen. The optimal bronchodilatatoric effect was always present.

Aerosols↗
PubMed1979

[Clinical-functional emphysema diagnostics and immunological correlations (author's transl)].

By application of the correlation flow resistance/intrathoracic gas volume the lung emphysema is differentiated in quality within the scope of chronic obstructive lung diseases. For these groups immunoglobulins, the alpha1-trypsin activity in serum and the activity of further protease inhibitors were determined. There are no substantial variables in the different groups with regard to immunoglobulins. In the emphysema group alpha1-antitrypsin was a little reduced. This group included 2 patients with an alpha1-antitrypsin deficit. The two-dimensional separation of the inter-alpha-trypsin big inhibitor shows 3 areas which decrease significantly in case of severe emphysemata. The irritation of the inter-alpha-trypsin big inhibitor, i.e. in its turnover, parallel to the increasing degree of emphysema formation, is discussed.

Adult↗
PubMed1979

The role of upper airways and of sensoric receptors on reflex bronchoconstriction.

The influence of bilateral transection of the nervi laryngici cranialis, laryngici caudalis and glossopharyngici on ACH and allergen-induced bronchoconstriction was tested in 15 dogs. In three dogs the free preparation of bilateral nervi laryngici cranialis was performed for control measurements. Partial transection of pulmonary left nervus vagus was performed in three dogs and compared to radical transection of the same nerve in three animals. Transection of the nervi laryngici cranialis as well as of the nervi glossopharyngici was followed by the inhibition of the allergen-induced bronchoconstriction. The bronchoconstriction following ACH challenge was not influenced by transection. Bronchoconstriction induced by allergen returned to the same values within three weeks after surgical intervention. Partial unilateral dissection of the vagus nerve on lung hilus shows a small decrease in bronchial constriction induced by allergen and by ACH. Complete unilateral dissection of the vagus nerve on the lung hilus reduced the bronchial constrictoric response to both substances significantly.

Acetylcholine↗
PubMed1979

Tracheal contractility and flow resistance in anesthetized dogs with and without vagal block.

The study was carried out on 8 boxer dogs in three groups. They were anesthetized, intubated and breathed spontaneously. The animals were exposed to inhalative acetylcholine (ACH) aerosol, mechanical stimulus to the bronchial tree, intrabronchial and intravenous application of ACH solution. Dynamic elasticity, lung resistance, tracheal resistance and breathing rates were determined. A special method was used for recording tracheal activity in spontaneously breathing animals and noted as tracheal pressure. Those parameters were noted before and after partial blocking of the cervical vagus nerves on both sides. Bilateral vagal block entirely prevented the response produced by mechanical irritation and intrabronchial ACH. Inhalative and intravenous ACH produced significantly less response after vagal block, but certain residues remained. It is concluded that mechanical irritation works entirely through the reflex path, but ACH mostly follows the reflex path a little on the smooth muscle directly.

Acetylcholine↗
PubMed1979

The role of upper airways in antigen-induced bronchoconstriction.

The bronchoconstrictor effect of antigen was tested in 15 dogs. The upper and the lower airways were sequently exposed through a specially confected endotracheal tube. The antigen was also generally administered through a mouth mask. Bronchoconstriction was induced after each kind of exposure. The results argue for reflex bronchoconstriction. The sensory receptors localized in the upper part of the airways are responsible for about 50% of antigen-induced bronchoconstriction. The decrease of PO2a was less marked following Ascaris suum extract aerosol administration to the upper part of the airways. Control measurements demonstrated the reproducibility of antigen-induced bronchoconstriction.

Aerosols↗
PubMed1979

The location of sensoric bronchoconstricting receptors in the upper airways.

The bronchoconstrictoric influence of allergen and acetylcholine aerosol was tested in 16 boxer dogs. The animals were exposed to these substances through a mask. The aerosol was also administered directly to three restricted areas of the trachea. Both substances induced a strong bronchoconstriction when administered through the mouth. Only the allergen showed a similar strong bronchoconstriction when administered to a restricted area in the upper third of the trachea.

Acetylcholine↗