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Biomedical subjects

W Theisinger

Publications and source records attributed to W Theisinger.

At least 19 recordsLinked to original sources
PubMed1981

[Postoperative thromboembolism prophylaxis with a reduced low dose heparin fraction and dihydroergotamine in fixed combination (author's transl)].

In a prospective randomized study th efficacy and tolerance of the conventional low dose heparin regimen was compared with a new combination of dihydroergotamine (DHE) and a reduced proportion of heparin (Heparin-Dihydergot 2500) with regard to postoperative thromboembolism prophylaxis in 350 general surgical patients. The result showed that the new combination had the same thrombotic protective action as low dose heparin monotherapy, but with regard to the concomitant risk of hemorrhage it seemed a significantly superior prophylactic variant.

Abdomen↗
PubMed1977

[Quantitative assessment of drug-induced prophylaxis of postoperative thromboembolism. Comparison of frequencies of deep vein thrombosis and pulmonary embolism using acetylsalicylic-acid, dextran, dihydroergotamine, low-dose heparin and the fixed combination of heparin and dihydroergotamine (author's transl)].

2136 patients in general surgery, gynaecology and urology were investigated by the 125I-fibrinogen-uptake-test for detection of postoperative deep vein thrombosis (DVT). They received at random one of low-dose heparin, dihydroergotamine, the fixed combination of both drugs (Heparin-Dihydergot), low molecular weight dextran and acetylsalicylic-acid (ASS). When DVT was detected repeated lung perfusion scintigraphies were carried out for diagnosis of embolic pulmonary perfusion defects. Results demonstrate the outstanding effect of Heparin-Dihydergot, which is not only 2-3 times better than the anti-thrombotic standard low-dose heparin but also eliminates almost completely the risk of postoperative embolism. The preventive efficacy of ASS and dextran must be considered to be poor and not comparable to that obtained when using heparin, dihydroergotamine or the combination. Now Heparin-Dihydergot is the new standard with which all prophylactic procedures should be compared.

Adult↗
PubMed1977

[Diagnostic and therapeutic problems of the stress ulcer].

Several examples show the five pathogenetic patterns of stress-ulcer induction. Own clinical experiences with 60 cases of stress-ulcers from 1973 to 1974 are described. Our studies on the effect of Vit. A und STH on stress-ulcera are compared with those of other authors and are critically discussed. The different excretion patterns of the group I and group II pepsinogens are pointed out. Difficulties exist not only from here but also from the unknown correlation between serum and urine pepsinogens as far as the attempt is concerned, to work out a pattern to diagnose stress-ulcera before they become clinically manifest.

Animals↗
PubMed1976

Prevention of postoperative thromboembolism by various treatments. Controlled clinical trial in 632 patients using 125I-fibrinogen uptake test and lung perfusion scans in patients with deep venous thrombosis.

In 632 patients efficacy of dihydroergotamine (DHE) in preventing postoperative deep venous thrombosis (DVT) and pulmonary embolism (PE) was tested vs. low-dose heparin (LDH) by means of the 125I-fibrinogen uptake test (RFUT). The incidence rate of DVT dropped from 36% (untreated group) to 17% after LDH, to 13% after DHE, and to 9% after simultaneous prophylaxis with both drugs. In patients with lower risk operations lasting not longer than 2 hs complete prevention of DVT was achieved by combined use of LDH and DHE. PE incidence in repeated lung perfusion scans of patients with positive RFUT was reduced to 4.3-2.6% (treated groups) in comparison to an incidence of 50% in the control group. This means the decrease of PE was overproportional in all treatment groups in comparison to the decrease of DVT incidence. The combined use of LDH and DHE may be considered as the best prophylactic regimen available for lowering postoperative DVT and PE.

Clinical Trials as Topic↗
PubMed1975

[Prevention of postoperative thrombo-embolism using a new principle of drug treatment (author's transl)].

Slowing of venous return is, in addition to endothelial damage and hypercoagulability, one of the decisive factors in the development of thrombi. This is especially so in operated patients with loss of vessel tone caused by general anaesthesia. The radiofibrinogen test was used on a group of 106 patients to check whether the administration of dihydroergotamine, which produces vasoconstriction particularly of the venous channels, can bring about a reduction in the incidence of postoperative thrombo-embolism. There was a statistically (variance analysis) highly significant difference in the average thrombosis rate between treated (8.8%) and untreated (34.7%) patients. In patients especially at risk, the rate was more than three times as high in the untreated group (39.5% and 12.9%, respectively). In low-risk patients the rate actually dropped to zero (from 20%).

Adult↗
PubMed1975

[Early recognition of relapse hazards following thyroidectomy using TSH serum level].

The determination of the serum level of TSH, the essential factor in goitrogenesis, was the best indicator in order to recognize imminent recurrence of goitre in strumectomized patients. The functional reserve of the hypothalamic-pituitary system proved to be important: Elevation of basic TSH level and increase of TSH after stimulation with TRH was significantly higher in patients with recurrent goitre. We, therefore, recommend this test for the postoperative surveillance of patients after strumectomy.

Female↗