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Biomedical subjects

W Thiemanun

Publications and source records attributed to W Thiemanun.

7 recordsLinked to original sources
PubMed1980

Chemosuppressive field trials in Thailand. IV. The suppression of Plasmodium falciparum and Plasmodium vivax parasitemias by mefloquine (WR 142,490, A 4-quinolinemethanol).

The effect of various dosages of mefloquine hydrochloride (WR 142,490) and sulfadoxine-pyrimethamine in the suppression of malaria infections was studied in an area of northeastern Thailand highly endemic for both chloroquine-resistant Plasmodium falciparum and for P. vivax. Both preparations, in all regimens studied, were effective in greatly reducing the incidence of falciparum infections. Mefloquine was more active in preventing vivax parasitemia than sulfadoxine-pyrimethamine; however, this combination remains the commercially available regimen of choice where both parasites occur and P. falciparum is resistant to chloroquine.

Adolescent↗
PubMed1975

Longitudinal malaria studies in rural Northeast Thailand. Chloroquine treatment of falciparum malaria infections.

The efficacy of chloroquine in the treatment of falciparum malaria was studied in two villages in Northeast Thailand, an area endemic for chloroquine-resistant falciparum infections. Chloroquine did not appear to reduce the duration or density of parasitemias experienced by asymptomatic villagers, but did benefit, usually temporarily, many subjects with symptomatic or high-density infections. These observations suggest that the high prevalence of chloroquine-resistant infections in the villages is similar to data from the hospital and clinics serving the area. The question whether chloroquine should remain available to this population should be evaluated.

Adult↗
PubMed1975

Chemosuppressive field trials in Thailand. II. The suppression of Plasmodium falciparum and Plasmodium vivax parasitemias by a diformyldapsone-pyrimethamine combination.

In an area of Thailand where chloroquine-resistant falciparum malaria is known to exist, a chemosuppressive field trial was undertaken to test the efficacy of the preparation diformyldapsone (DFD) combined with pyrimethamine (Py) in suppressing falciparum and vivax parasitemias. Six hundred and fifty-nine Thai villagers were randomly assigned to one of five treatment groups: DFD-Py; dapsone (DDS)-Py; DFD alone; Py alone; and placebo. Five hundred and ninety-three study subjects completed the 26-week trial. The combination DFD-Py given weekly was shown to be an effective chemosuppressive against both falciparum and vivax parasitmias, causing a more than fourfold reduction in falciparum and an approximately threefold reduction in vivax parasitemias; however, this combination was not more efficacious than DDS-Py for the chemosuppression of falciparum malaria. DFD alone was only moderately effective, while there was no difference in chemosuppression between Py alone and placebo.

Adolescent↗
PubMed1974

Longitudinal malaria studies in rural north-east Thailand: demographic and temporal variables of infection.

A prospective longitudinal study of malaria incidence was carried out in randomly selected samples of the population in the villages of Bu Phram and Tablan, north-east Thailand. During the 10-month study period 46% of the 252 persons followed up experienced a falciparum parasitaemia, and 23% a vivax parasitaemia. The peak of the cases occurred during a 10-week period from late May to the end of July, with transmission apparently continuing, at lower levels, throughout the remainder of the study period. Falciparum infection rates were higher for residents of Bu Pham; vivax infection rates were the same in both villages. Certain indices declined with age in Bu Phram but not in Tablan residents. Parasite rates were higher for males than for females. Age-specific rates did not vary predictably. Infection of children aged less than one year was rare.

Adolescent↗