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Biomedical subjects

W Thorburn

Publications and source records attributed to W Thorburn.

At least 37 records · Page 2Linked to original sources
PubMed1988

The outcome of visual function in capsular glaucoma.

In a retrospective study is found that 2.5% of subjects aged 70 years or more developed visual field defects due to capsular glaucoma within their lifetime. Before death 0.8% were amaurotic in one eye, and 0.3% had serious impaired visual function caused by bilateral capsular glaucoma. Advanced visual field defects present at diagnosis and central vein occlusion contributed to bad outcome. When glaucomatous disc cupping without visual field defects were present at diagnosis, 50% developed field defects during their lifetime. Of those with moderate visual field defects at diagnosis 59% advanced one or more stages.

Aged↗
PubMed1988

Treatment versus no treatment in chronic open angle glaucoma.

In a controlled randomized study 15 patients (20 eyes) with chronic open angle glaucoma and visual field defects were followed by greater than 1 year, 12 of them were followed for 3 years. Half of the group were untreated controls, the other half treated with pressure reducing medical therapy. At least 5 consecutive computerized visual fields were recorded (COMPETER) on each eye, and the linear regression coefficient was calculated. With the reservation for uncontrolled compliance no significant difference in the line of favourable effect of pressure reduction could be spotted, in spite of an average pressure reduction in the treated group of 4 mmHg. More important than this result, which is open to criticism for the smallness of the material, uncontrolled compliance etc, is the lesson that a randomized experiment with treated and non-treated glaucoma cases carried out in accordance with the Helsingfors convention is hardly feasible.

Aged↗
PubMed1986

Goniodysgenesis in elderly glaucoma and non-glaucoma patients. A masked slit-lamp and gonioscopy study.

The aim was to elucidate whether goniodysgenesis is more frequently observed in elderly patients with glaucoma, and furthermore, which signs of goniodysgenesis are of importance and most unanimously detected. Thus, 3 examiners evaluated 21 glaucoma patients and 19 non-glaucoma patients in a masked fashion. None of the patients had a first-degree heredity. Gonioscopy, slit-lamp examination and measurements of the corneal and pupillary diameter were performed, in all 26 variables. Significantly (P less than 0.05) more frequent in glaucoma were an increased corneal diameter, scleral overriding, hypoplasia of the pupillary seam, abnormal Schwalbe's line and an opaque pretrabecular membrane (one examiner). Less frequent were a peripupillary yellow pigment ring and pigment stars on the lens. Inter-observer variation was small regarding e.g. corneal diameter but rather large regarding e.g. the pretrabecular membrane.

Aged↗
PubMed1985

Intraocular pressure after cataract surgery with Healon.

We studied the intraocular pressure (IOP) following extracapsular cataract extraction and posterior chamber lens implantation in 75 cases. Sodium hyaluronate (Healon) was used in all cases. In 40 cases, Healon was left in the eyes; in 35, the eyes were irrigated to remove Healon from the anterior chamber. When Healon was left in the eyes, 35% had an IOP increase of greater than or equal to 20 mm Hg during the initial ten hours, compared to 11% of the group in which Healon was irrigated out. Twenty hours after surgery, the irrigated eyes had an average lower IOP than the nonirrigated eyes, 15.6 mm Hg versus 23.8 mm Hg.

Cataract Extraction↗
PubMed1984

Observed incidence of glaucoma in Hälsingland, Sweden.

In a well defined population, the observed incidence of different types of glaucoma during the years 1980-82 is presented. The great majority of glaucoma patients was found to have primary open angle glaucoma, and of these approximately 3/4 had capsular glaucoma. The observed annual incidence of all types of glaucoma increases with increasing age to a maximum of 0.7% in the age group 81-85 years. In the same age group, the annual incidence of primary open angle glaucoma with visual field defects was 0.44%.

Age Factors↗
PubMed1984

Functional damage at diagnosis of primary open angle glaucoma.

In a well defined population, all patients with newly diagnosed primary open angle glaucoma were classified according to the degree of functional damage at diagnosis. A comparison was made between patients with simple and capsular glaucoma. No difference could be found between the 2 types of glaucoma when the severity of visual damage at diagnosis was compared. Eyes with capsular glaucoma were found to have significantly higher intraocular pressure than eyes with simple glaucoma in corresponding glaucoma stage. No obvious correlation between age and functional damage at diagnosis was found.

Age Factors↗
PubMed1983

Survival time among patients with glaucomatous visual field defects.

During our studies on glaucoma we have made an important and surprising observation. We think it is urgent to report that we have found the survival time of glaucoma patients seems to be substantially shortened. To the best of our knowledge this has not been previously reported.

Aged↗
PubMed1982

Prevalence of visual field defects due to capsular and simple glaucoma in Hälsingland, Sweden.

In a region where both simple and capsular glaucoma are common, the observed prevalence of glaucoma with glaucomatous visual field defects based on hospital records is presented. The prevalence increased with increasing age to a maximum of 4.5% of the age group 81-85. Capsular glaucomas accounted for two thirds of the glaucomatous visual field defects. A comparison with previous population surveys indicates that the frequency of simple glaucoma is of the same magnitude as elsewhere. The high frequency of glaucomatous visual field defects can be due to the occurrence of capsular glaucoma. This supports the hypothesis that capsular glaucoma has its own epidemiology.

Adolescent↗
PubMed1980

Dominantly inherited macular degeneration (Best's disease) in a homozygous father with 11 children.

In Sweden, more than 250 cases of hereditary macular degeneration (HMD), inherited as an autosomal dominant trait and consistent with Best's disease, have been traced to one gene source in the 17th century. In this large material an apparently homozygous father was found, who was aged 56 and had 11 affected children. One of the children, aged 24, did not show any macular degeneration, but nevertheless she was considereds to be a carrier of the HMD-gene because she had pathological EOG-values. The great variations in expressivity of the disease in the 11 children reflected what has been found as a rule in large Swedish families with HMD. The homozygotic stage did not seem to differ in clinical appearance from the heterozygotic.

Adolescent↗
PubMed1980

Absence of cataract ten years after treatment with 8-methoxypsoralen.

Thirteen patients treated with 4-41 g of 8-methoxypsoralen (8-MOP) for vitiligo were examined with regard to ocular damage 2-12 years after start of the treatment. No signs of eye damage were registered. This result indicates the need for more comprehensive retrospective examinations of 8-MOP-treated patients in order to gain information on the practical risk of cataract formation.

Adult↗
PubMed1978

The accuracy of clinical applanation tonometry.

The differences between two careful applanation tonometries performed by one and by two observers, respectively, were compared. Two measurements by one observer differed by 2 mmHg or more in 8% of the pairs of measurements and by 3 mmHg or more in 2% of the pairs. One tonometry each by two observers differed by 2 mmHg or more 40% of the pairs of measurement and by 3 mmHg or more in 17% of the pairs. There was no dependence on the intraocular pressure. Possible reasons for the increase in variance are discussed.

Evaluation Studies as Topic↗
PubMed1978

Prognosis of glaucoma simplex and glaucoma capsulare. A comparative study.

To study the prognosis of capsular glaucoma (102 eyes) as compared to simplex glaucoma (58 eyes), a retrospective comparison of the functional status of these diseases when first diagnosed and five years afterwards was made. At the first examination the capsular glaucoma eyes were on average more seriously damaged. After five years this tendency was more marked with several amaurotic eyes, 17% as compared to 10% of the simplex glaucoma group. Severe visual field loss in the eyes with advanced glaucoma after five years was present in 48% of the capsular glaucoma group but only 19% of the simplex glaucoma group.

Adult↗
PubMed1978

EOG in a large family with hereditary macular degeneration. (Best's vitelliform macular dystrophy) identification of gene carriers.

A total of 128 descendants from one large family with a history of hereditary macular degeneration (HMD) were examined with EOG. Of these, 42 were affected patients, 48 were healthy offsprings to affected parents, and 38 were normal controls. Affected subjects had a light peak/dark trough ratio smaller than 1.40. In the group of offspring of affected parents the Lp/DT ratios showed a bimodal distribution dividing the group into two parts, one with values less than 1.40 and another with values larger than 1.70. Thus carriers of the HMD gene can apparently be identified by use of EOG. The affected subjects and the carriers had a lower base value of the standing potential than the controls.

Adolescent↗
PubMed1976

Etidocaine in retrobulbar anaesthesia. A comparison with mepivacaine.

A new long-acting local anaesthetic, etidocaine (Duranest) has been compared to mepivacaine (Carbocaine) in retrobulbar anaesthesia in a double-blind trial including 45 patients. Solutions used were etidocaine 0.5% and 1% and mepivacaine 1%, all without adrenaline. The onset time was short and no difference was found between the solutions. The duration of analgesia and motor block was significantly longer with etidocaine 1% compared to mepivacaine 1%. In a following open study with etidocaine 1% and mepivacaine 1% about 80% of the the patients in the etidocaine group never experienced any post-operative pain compared to about 50% in the mepivacaine group. No signs of local or systemic toxicity were noted in the studies.

Acetanilides↗
PubMed1976

Transient glaucoma as a manifestation of mumps. A case report.

A case report of a 43-year-old man who during convalescence after mumps (parotitis epidemica) developed bilateral glaucoma associated with redness of his eyes but no other ocular manifestations. The chamber angles were open. No signs of scleritis or iritis were present. The best treatment was found to be prednisolone topically and acetazolamide orally. After ten days the intraocular pressure was normalized and after a fortnight all treatment could be discontinued.

Acetazolamide↗
PubMed1975

Herpes zoster in general practice.

Eighty-seven patients with the clinical diagnosis of herpes zoster were seen during a one-year period in eight general practices in Glasgow, the rate per 1,000 practice population being approximately 2.4. Of these, 78 (90 per cent) had serological evidence of active infection with herpes zoster. The anatomical location of the skin eruption was most common in the areas of the fifth cranial nerve, middle and lower trunk and thigh. A possible reactivating agent (trauma four, steroids two, irradiation one) was found in only seven patients. The illness as assessed by systemic upset and dissemination of lesions was generally not severe. Post-herpetic neuralgia was the most troublesome complication, found in 44 per cent of 64 patients revisisted 3-18 months after the acute illness.

Adult↗